The role of p53 and autophagy in Dasatinib resistance of CLL lymphocytes

Leukemia Research

Volumn 35, Issue 1, 2011, Pages 32-33

  Pitini, Vincenzo V ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Autophagy; Dasatinib; p53

Indexed keywords

BH3 PROTEIN; DASATINIB; DNA; PROTEIN BCL 2; PROTEIN P53;

AUTOPHAGY; CANCER RESISTANCE; CELL SURVIVAL; CHROMOSOME 17P; CHROMOSOME DELETION; CHRONIC LYMPHATIC LEUKEMIA; CYTOTOXICITY; DNA DAMAGE; DRUG RESPONSE; DRUG SENSITIVITY; DRUG TARGETING; EDITORIAL; GENE MUTATION; HUMAN; LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; PYRIMIDINES; THIAZOLES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 78650171364     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.07.007     Document Type: Editorial

References (5)

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2. Veldurthy A., Patz M., Hagist S., et al. The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes. Blood 2008, 112:1443-1452.
3. Amrein L., Panasci L., Gibson S.B., et al. Primary del 17 chronic lymphocytic leukaemia lymphocytes are hypersensitive to dasatinib in vitro. British Journal of Haematology 2009, 147:396-398.
4. Amrein L., Soulieres D., Johnston J., Aloyz R. p53 and autophagy contribute to Dasatinib resistance in primary CLL lymphocytes. Leuk Res 2011, 35:99-102.
5. Tasdemir E., Maiuri M.C., Morselli E., et al. A dual role of p53 in the control of autophagy. Autophagy 2008, 4(6):810-814.