ARTICLE;
AUTOPHAGY;
CANCER RESISTANCE;
CHROMOSOME DELETION;
CHRONIC LYMPHATIC LEUKEMIA;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
DRUG MECHANISM;
DRUG SENSITIVITY;
ENDOPLASMIC RETICULUM STRESS;
HUMAN;
HUMAN CELL;
IC 50;
IN VITRO STUDY;
LYMPHOCYTE;
PRIORITY JOURNAL;
PROGNOSIS;
PROTEIN EXPRESSION;
PROTEIN FUNCTION;
PROTEIN PHOSPHORYLATION;
SIGNAL TRANSDUCTION;
ANTINEOPLASTIC AGENTS;
AUTOPHAGY;
DRUG RESISTANCE, NEOPLASM;
HUMANS;
LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL;
PYRIMIDINES;
THIAZOLES;
TUMOR SUPPRESSOR PROTEIN P53;
Activities of SYK and PLCgamma2 predict apoptotic response of CLL cells to SRC tyrosine kinase inhibitor dasatinib
Song Z., Lu P., Furman R.R., et al. Activities of SYK and PLCgamma2 predict apoptotic response of CLL cells to SRC tyrosine kinase inhibitor dasatinib. Clin Cancer Res 2010, 16:587-599.
Dasatinib has activity in relapsed/refractory chronic lymphocytic leukemia (CLL/SLL), a phase II trial
Amrein P.C., Attar E., Takvorian T., et al. Dasatinib has activity in relapsed/refractory chronic lymphocytic leukemia (CLL/SLL), a phase II trial. Blood 2008, 112:1084-11084.
Primary del 17 chronic lymphocytic leukaemia lymphocytes are hypersensitive to dasatinib in vitro
Amrein L., Panasci L., Gibson S.B., Johnston J.B., Soulières D., Aloyz R. Primary del 17 chronic lymphocytic leukaemia lymphocytes are hypersensitive to dasatinib in vitro. Br J Haematol 2009, 147:396-398.
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
Bellodi C., Lidonnici M.R., Hamilton A., et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009, 119:1109-1123.