Association of IL-6 and IL-6R gene polymorphisms with susceptibility to respiratory tract infections in young Finnish men

Human Immunology

Volumn 72, Issue 1, 2011, Pages 63-68

  Rantala, Aino ^a,b   Lajunen, Taina ^a   Juvonen, Raija ^c   Silvennoinen Kassinen, Sylvi ^b   Peitso, Ari ^d   Vainio, Olli ^b,e   Saikku, Pekka ^b   Leinonen, Maija ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c KAINUU CENTRAL HOSPITAL   (Finland)

^d CENTRE FOR MILITARY MEDICINE   (Finland)

^e OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Conscript; IL 6; IL 6 receptor; Polymorphism; Respiratory tract infection

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

5' UNTRANSLATED REGION; ADULT; ARTICLE; ASTHMA; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INFECTION RISK; INFLAMMATION; INTRON; MAJOR CLINICAL STUDY; MALE; MILITARY SERVICE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROMOTER REGION; RESPIRATORY TRACT INFECTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; FINLAND; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-6; MALE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-6; RESPIRATORY TRACT INFECTIONS; RISK ASSESSMENT; YOUNG ADULT;

EID: 78650170845     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2010.10.010     Document Type: Article

References (29)

1. Nicod L.P. Cytokines. 1. Overview. Thorax 1993, 48:660-667.
2. Heinrich P.C., Behrmann I., Muller-Newen G., Schaper F., Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 1998, 334:297-314.
3. Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Muller-Newen G., Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003, 374:1-20.
4. Schuster B., Meinert W., Rose-John S., Kallen K.J. The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane. FEBS Lett 2003, 538:113-116.
5. Jones S.A., Rose-John S. The role of soluble receptors in cytokine biology: The agonistic properties of the sIL-6R/IL-6 complex. Biochim Biophys Acta 2002, 1592:251-263.
6. Wolford J.K., Colligan P.B., Gruber J.D., Bogardus C. Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. Mol Genet Metab 2003, 80:338-343.
7. Galicia J.C., Tai H., Komatsu Y., Shimada Y., Ikezawa I., Yoshie H. Interleukin-6 receptor gene polymorphisms and periodontitis in a non-smoking Japanese population. J Clin Periodontol 2006, 33:704-709.
8. Hamid Y.H., Urhammer S.A., Jensen D.P., Glumer C., Borch-Johnsen K., Jorgensen T., et al. Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites. Diabetes 2004, 53:3342-3345.
9. Vozarova B., Fernandez-Real J.M., Knowler W.C., Gallart L., Hanson R.L., Gruber J.D., et al. The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians. Hum Genet 2003, 112:409-413.
10. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., Woo P. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998, 102:1369-1376.
11. Humphries S.E., Luong L.A., Ogg M.S., Hawe E., Miller G.J. The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J 2001, 22:2243-2252.
12. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81:559-575.
13. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
14. Patel J.A., Nair S., Revai K., Grady J., Saeed K., Matalon R., et al. Association of proinflammatory cytokine gene polymorphisms with susceptibility to otitis media. Pediatrics 2006, 118:2273-2279.
15. Revai K., Patel J.A., Grady J.J., Nair S., Matalon R., Chonmaitree T. Association between cytokine gene polymorphisms and risk for upper respiratory tract infection and acute otitis media. Clin Infect Dis 2009, 49:257-261.
16. Qi L., Rifai N., Hu F.B. Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. women. Diabetes 2007, 56:3075-3081.
17. Qi L., Rifai N., Hu F.B. Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women. Diabetes 2009, 58:275-278.
18. Esteve E., Villuendas G., Mallolas J., Vendrell J., Lopez-Bermejo A., Rodriguez M., et al. Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome, in. Clin Endocrinol (Oxf) 2006, 65:88-91.
19. Bustamante M., Nogues X., Mellibovsky L., Agueda L., Jurado S., Caceres E., et al. Polymorphisms in the interleukin-6 receptor gene are associated with bone mineral density and body mass index in Spanish postmenopausal women. Eur J Endocrinol 2007, 157:677-684.
20. Mullberg J., Oberthur W., Lottspeich F., Mehl E., Dittrich E., Graeve L., et al. The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site. J Immunol 1994, 152:4958-4968.
21. Jones S.A., Horiuchi S., Topley N., Yamamoto N., Fuller G.M. The soluble interleukin 6 receptor: Mechanisms of production and implications in disease. FASEB J 2001, 15:43-58.
22. Kim L.H., Lee H.S., Kim Y.J., Jung J.H., Kim J.Y., Park B.L., Shin H.D. Identification of novel SNPs in the interleukin 6 receptor gene (IL6R). Hum Mutat 2003, 21:450-451.
23. Luchtefeld M., Schunkert H., Stoll M., Selle T., Lorier R., Grote K., et al. Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man. J Exp Med 2007, 204:1935-1944.
24. Latvala J., von Hertzen L., Lindholm H., Haahtela T. Trends in prevalence of asthma and allergy in Finnish young men: Nationwide study, 1966-2003. BMJ 2005, 330:1186-1187.
25. Kajosaari M. Asthma and adolescence (Finnish). Suom Laakaril 2004, 59:2135-2138.
26. Yokoyama A., Kohno N., Sakai K., Kondo K., Hirasawa Y., Hiwada K. Circulating levels of soluble interleukin-6 receptor in patients with bronchial asthma. Am J Respir Crit Care Med 1997, 156:1688-1691.
27. + Treg development and function during allergic airway inflammation in vivo. J Clin Invest 2005, 115:313-325.
28. Rantala A., Lajunen T., Juvonen R., Bloigu A., Silvennoinen-Kassinen S., Peitso A., et al. Mannose-binding lectin concentrations, MBL2 polymorphisms, and susceptibility to respiratory tract infections in young men. J Infect Dis 2008, 198:1247-1253.
29. Ioannidis J.P., Ntzani E.E., Trikalinos T.A., Contopoulos-Ioannidis D.G. Replication validity of genetic association studies. Nat Genet 2001, 29:306-309.