Induced thyme product prevents VEGF-induced migration in human umbilical vein endothelial cells

Biochemical and Biophysical Research Communications

Volumn 403, Issue 3-4, 2010, Pages 275-281

  Krill, Diane ^b   Madden, John ^b   Huncik, Kevin ^a   Moeller, Peter D ^a  

^a Hollings Marine Laboratory   (United States)

^b POINT PARK UNIVERSITY   (United States)

Author keywords

Angiogenesis inhibitors; Cell culture; HPLC; Thyme; Zebrafish

Indexed keywords

AMILORIDE; ANGIOGENESIS INHIBITOR; INDUCIBLE VASCULAR FACTOR 3; PLANT EXTRACT; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG EFFICACY; DRUG SCREENING; EMBRYO; ENDOTHELIUM CELL; EPITHELIUM CELL; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VIVO STUDY; KIDNEY EPITHELIUM; MALE; NONHUMAN; PLANT PRODUCT; PLANT ROOT; PLANT TISSUE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THYME; UMBILICAL VEIN; ZEBRA FISH;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL MOVEMENT; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOTHELIAL CELLS; HUMANS; METHANOL; NEOVASCULARIZATION, PHYSIOLOGIC; THYMUS PLANT; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

DANIO RERIO; MENTHA; THYMUS VULGARIS; VERTEBRATA;

EID: 78650170204     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.11.014     Document Type: Article

References (30)

1. Bais H.P., Vepachedu R., Gilroy S., Callaway R.M., Vivanco J.M. Allelopathy and exotic plant invasion: from molecules and genes to species interactions. Science 2003, 301:1377-1380.
2. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1995, 1:27-31.
3. Das A., McGuire P.G. Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition. Prog. Retin. Eye Res. 2003, 6:721-748.
4. Lam H.-W., Lin H.-C., Lao S.-C., Gao J.-L., Hong S.-J., Leong C.-W., Yue P.Y.-K., Kwan Y.-W., Leung A.Y.-H., Wang Y.-T., Lee S.M.-Y. The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo. J. Cell. Biochem. 2008, 103:195-211.
5. de Rijke E., Out P., Niessen W.M.A., Ariese F., Gooijer C., Brinkman U.A. Analytical separation and detection methods for flavonoids. J. Chromatogr. A 2006, 1112:31-63.
6. Das D.K. Naturally occurring flavonoids: structure, chemistry, and high performance liquid chromatography methods for separation and characterization. Methods Enzymol. 1994, 234:410-420.
7. Laughton M.J., Halliwell B., Evans P.J., Hoult J.R.S. Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin: effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. Biochem. Pharmacol. 1989, 38:2859-2865.
8. Das M., Ray P.K. Lipid antioxidant properties of quercetin in vitro. Biochem. Int. 1988, 17(2):203-209.
9. Dryden G.W., Song M., McClain C. Polyphenols and gastrointestinal diseases. Curr. Opin. Gastroenterol. 2006, 22(2):165-170.
10. Kim H.P., Son K.H., Chang H.W., Kang S.S. Anti-Inflammatory plant flavonoids and cellular action mechanisms. J. Pharmacol. Sci. 2004, 96:229-245.
11. DeLeo M., Braca A., Sanogo R., Cardile V., DeTommasi N., Russo A. Antiproliferative activity of pteleopsis suberosa leaf extract and its flavonoid components in human prostate carcinoma cells. Planta Med. 2006, 72(7):604-610.
12. Gazak R., Walterova D., Kren V. Silybin and silymarin-new and emerging applications in medicine. Curr. Med. Chem. 2007, 14(3):315-338.
13. Bobe G., Albert P.S., Sansbury L.B., Lanza E., Schatzkin A., Colbum N.H., Cross A.J. Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial. Canc. Prev. Res. 2010, 3(6):764-775.
14. Schindler R., Mentlein R. Flavonoids and vitamin E reduce the release of the angiogenic peptide VEGF from human tumor cells. J. Nutr. 2006, 136(6):1477-1482.
15. Noonan D.M., Benelli R., Albini A. Angiogenesis and cancer prevention: a vision. Recent Results Cancer Res. 2007, 174:219-224.
16. López-Lázaro M. Distribution, biological activities of the flavonoid luteolin. Mini Rev. Med. Chem. 2009, 1:31-59.
17. Hanneken A., Lin F.F., Johnson J., Maher P. Flavonoids protect human retinal pigment cells from oxidative stress-induced death. Invest. Ophthalmol. Vis. Sci. 2006, 47(7):3164-3177.
18. Thisse C., Zon L.I. Organogenesis-heart and blood formation from the zebrafish point of view. Science 2002, 295(5554):457-463.
19. Stainier D.Y.R. Zebrafish genetics and vertebrate heart formation. Nat. Rev. Gen. 2002, 2:39-48.
20. Serbedziya G.N., Flynn E., Willett C.E. Zebrafish angiogenesis: a new model for drug screening. Angiogenesis 1999, 3:353-359.
21. Beeken W.D., Engl T., Hofmann J., Jonas D., Blaheta R. Clinical relevance of serum angiogenic activity in patients with transitional cell carcinoma of the bladder. J. Cell. Mol. Med. 2005, 9:655-661.
22. Cross L.M., Cook M.A., Lin S., Chen J.N., Rubinstein A.L. Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay. Arterioscler. Thromb. Vasc. Biol. 2003, 23:911-912.
23. Li P., Zhang Y., Hua X., Ito Y. Studies on the preparative capability of the horizontal flow-through coil planet centrifuge and high-performance liquid chromatography in the separation of polar compounds from Oxytropis ochrocephala Bunge. J. Chromatogr. 1991, 538(1):219-225.
24. Maher E.P., Bell C.J. Abnormal responses to gravity and auxin in mutants of Arabidopsis thaliana. Plant Science 1990, 66:131-138.
25. Motulsky H.J. Analyzing Data with GraphPad Prism 1999, GraphPad Software Inc., San Diego CA, Available from: .
26. Duewelhenke N., Krut O., Eysel P. Influence of mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. Antimicrob. Agents Chemother. 2007, 51(1):54-63.
27. Isogai S., Horiguchi M., Weinstein B.M. The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development. Dev. Biol. 2001, 230:278-301.
28. Shukla S., Gupta S. Dietary agents in the chemoprevention of prostate cancer. Nutr. Cancer 2005, 53(1):18-32.
29. Ny A., Autiero M., Cameliet P. Zebrafish and Zenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis. Exp. Cell Res. 2006, 312:684-693.
30. Vogel A.M., Weinstein B.M. Studying vascular development in the zebrafish. Trends Cardiovasc. Med. 2000, 10:352-360.