Discontinuing benzodiazepine therapy: An interdisciplinary approach at a geriatric day hospital

Canadian Pharmacists Journal

Volumn 143, Issue 6, 2010, Pages 286-295

  Chen, Lori ^a   Farrell, Barbara ^b,c   Ward, Natalie ^b,e   Russell, Grant ^b,c,d   Eisener Parsche, Pamela ^b,c   Dore, Naomi ^f  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b BRUYÈRE RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d MONASH UNIVERSITY   (Australia)

^e UNIVERSITY OF OTTAWA   (Canada)

^f UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZEPAM; FLURAZEPAM; LORAZEPAM; OXAZEPAM; TEMAZEPAM; TRAZODONE;

ADULT; AGED; ANXIETY DISORDER; ARTICLE; CLINICAL ARTICLE; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; GERIATRIC HOSPITAL; HEALTH CARE PERSONNEL; HEALTH SURVEY; HUMAN; INTERDISCIPLINARY COMMUNICATION; PHARMACY; TREATMENT OUTCOME;

EID: 78650147833     PISSN: 17151635     EISSN: 1913701X     Source Type: Journal    
DOI: 10.3821/1913-701X-143.6.286     Document Type: Article

References (36)

1. Hogan DB, Maxwell CJ, Fung TS, Ebly EM. Prevalence and potential consequences of benzodiazepine use in senior citizens: results from the Canadian Study of Health and Aging. Can J Clin Pharmacol 2003;10(2):72-7.
2. Tu K, Mamdani MM, Hux JE, Tu JB. Progressive trends in the prevalence of benzodiazepine prescribing in older people in Ontario, Canada. J Am Geriatr Soc 2001;49:1341-5.
3. Kassam A, Patten SB. Hypnotic use in population-based sample of over thirty-five thousand interviewed Canadians. Pop Health Metrics 2006;4(15):doi: 10.1186/1478-7954-4-15.
4. Neutel IC. The epidemiology of long-term benzodiazepine use. Int Rev Psychiatry 2005;17(5):189-97.
5. Curran HV, Collins R, Fletcher S, et al. Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life. Psychol Med 2003;33:1223-37.
6. Holbrook AM, Crowther R, Lotter A, et al. Meta-analysis of benzodiazepine use in the treatment of insomnia. CMAJ 2000;162:225-33.
7. Halcion product monograph. In: Repchinsky C, editor. Compendium of pharmaceuticals and specialties. Ottawa (ON): Canadian Pharmacists Association; 2007. p. 1057-8.
8. Mogadon product monograph. In: Repchinsky C, editor. Compendium of pharmaceuticals and specialties. Ottawa (ON): Canadian Pharmacists Association; 2007. p. 1487-8.
9. Restoril product monograph. In: Repchinsky C, editor. Compendium of pharmaceuticals and specialties. Ottawa (ON): Canadian Pharmacists Association; 2007. p. 2053-5.
10. Kruse WHH. Problems and pitfalls in the use of benzodiazepines in the elderly. Drug Saf 1990;5:328-44.
11. Barker MJ, Greenwood KM, Jackson M, Crowe SF. Cognitive effects of long-term benzodiazepine use: a meta-analysis. CNS Drugs 2004;18(1):37-48.
12. Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988;319:1701-7.
13. Neutel IC, Hirdes JP, Maxwell CJ, Patten SB. New evidence on benzodiazepine use and falls: the time factor. Age Ageing 1996;25:273-8.
14. Neutel IC, Perry S, Maxwell C. Medication use and risk of falls. Pharmacoepidemiol Drug Saf 2002;11:97-104.
15. Ray WA, Griffin MR, Downey W. Benzodiazepines of long and short elimination half-life and risk of hip fracture. JAMA 1989;262:3303-7.
16. Wagner AK, Zhang F, Soumerai SB, et al. Benzodiazepine use and hip fractures in the elderly. Arch Intern Med 2004;164:1567-72.
17. Wang PS, Bohn RL, Glynn RJ, et al. Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage, and duration on risk of hip fracture. Am J Psychiatry 2001;158:892-8.
18. Herings RM, Stricker BH, de Boer A, et al. Benzodiazepines and the risk of falling leading to fractures: dosage more important than elimination half-life. Arch Intern Med 1995;155:1801-7.
19. Linden M, Bar T, Geiselmann B. Patient treatment insistence and medication craving in long-term low-dosage benzodiazepine prescriptions. Psychol Med 1998;28:721-9.
20. Kales A, Manfredi RL, Vgontzas AN, et al. Rebound insomnia after only brief and intermittent use of rapidly eliminated benzodiazepines. Clin Pharmacol Ther 1991;49(4):468-76.
21. Farrell B. Falls caused by benzodiazepine use: solving the problem. Pharm Connect 1995 Sep/Oct:4-9.
22. Busto U, Sellers EM, Naranjo CA, et al. Withdrawal reaction after long-term therapeutic use of benzodiazepines. N Engl J Med 1986;315:854-9.
23. Cook JM, Marshall R, Masci C, Coyne JC. Physicians' perspectives on prescribing benzodiazepines for older adults: a qualitative study. Soc Gen Intern Med 2007;22:303-7.
24. Denis C, Fatséas M, Lavie E, Auriacombe M. Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings. Cochrane Database Syst Rev 2006;3:CD005194.
25. Schweizer E, Case WG, Rickels K. Benzodiazepine dependence and withdrawal in elderly patients. Am J Psychiatry 1989;146:529-31.
26. Marks J. Techniques of benzodiazepine withdrawal in clinical practice: a consensus workshop report. Med Toxicol 1988;3:324-33.
27. DA. Psychological strategies for discontinuing benzodiazepine treatment. J Clin Psychopharmacol 1999;19(6 Suppl 2):17s-22s.
28. Baillargeon L, Landreville P, Verreault R, et al. Discontinuation of benzodiazepines among older insomniac adults treated with cognitive-behavioural therapy combined with gradual tapering: a randomized trial. CMAJ 2003;169:1015-20.
29. Morin CM, Bastien C, Guay B, et al. Randomized clinical trial of supervised tapering and cognitive behavior therapy to facilitate benzodiazepine discontinuation in older adults with chronic insomnia. Am J Psychiatry 2004;161:332-42.
30. Bashir K, King M, Ashworth M. Controlled evaluation of brief intervention by general practitioners to reduce chronic use of benzodiazepines. Br J Gen Pract 1994;44:408-12.
31. Pimlott N, Hux J, Wilson L, et al. Educating physicians to reduce benzodiazepine use by elderly patients: a randomized controlled trial. CMAJ 2003;168:835-9.
32. Campbell M, Fitzpatrick R, Haines A, et al. Framework for design and evaluation of complex interventions to improve health. BMJ 2000;321:694-6.
33. Green LW, Kreuter MW. Health promotion planning: an educational and ecological approach. 3rd ed. Toronto (ON): Mayfield; 1999.
34. Dupotey NMV, de Oliveira DR. A qualitative glimpse at pharmaceutical care practice. Pharm World Sci 2009;31:690-11.
35. Health Canada. Seniors, sleeping pills and tranquillizers. 1 Oct. 2009. Available: www.phac-aspc.gc.ca/seniors-aines/altformats/pdf/publications/public/medication/sleep-dormir/pills-somniferes/pills-somniferes-eng.pdf (accessed October 17, 2010).
36. Sleep Wake Disorders Canada. Wake refreshed! How to get a good night's sleep [brochure]. Toronto, Canada.