Upregulation of fecal cytokeratin 19 is associated with prognosis in older colorectal cancer patients

Genetic Testing and Molecular Biomarkers

Volumn 14, Issue 5, 2010, Pages 703-708

  Yang, Ruey Neng ^a,b   Yang, Shung Haur ^c   Chang, Chun Chao ^d,e   Chien, Chih Cheng ^a,f   Pan, Shiann ^d,e   Huang, Chi Jung ^a,f,g  

^a CATHAY GENERAL HOSPITAL   (Taiwan)

^b CHING KUO INSTITUTE OF MANAGEMENT AND HEALTH   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^g NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 19;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER RISK; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; ENZYME INDUCTION; FECES ANALYSIS; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTASIS; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOCARCINOMA; AGE FACTORS; AGED; AGED, 80 AND OVER; CA-19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; COLORECTAL NEOPLASMS; FECES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; KERATIN-19; MALE; MIDDLE AGED; PROGNOSIS; STATISTICS, NONPARAMETRIC; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 78650145276     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2010.0047     Document Type: Article

References (37)

1. Bartek J, Bartkova J, Taylor-Papadimitriou J, et al. (1986) Differential expression of keratin 19 in normal human epithelial tissues revealed by monospecific monoclonal antibodies. Histochem J 18:565-575.
2. Benoy IH, Elst H, Philips M, et al. (2006) Real-time RT-PCR detection of disseminated tumour cells in bone marrow has superior prognostic significance in comparison with circulating tumour cells in patients with breast cancer. Br J Cancer 94:672-680.
3. Bielsa S, Esquerda A, Salud A, et al. (2009) High levels of tumor markers in pleural fluid correlate with poor survival in patients with adenocarcinomatous or squamous malignant effusions. Eur J Intern Med 20:383-386.
4. Bustin SA, Dorudi S (2004) Gene expression profiling for molecular staging and prognosis prediction in colorectal cancer. Expert Rev Mol Diagn 4:599-607.
5. Chang CC, Yang SH, Chien CC, et al. (2009) Clinical meaning of age-related expression of fecal cytokeratin 19 in colorectal malignancy. BMC Cancer 9:376-383.
6. Chen TF, Jiang GL, Fu XL, et al. (2007) CK19 mRNA expression measured by reverse-transcription polymerase chain reaction (RT-PCR) in the peripheral blood of patients with non-small cell lung cancer treated by chemo-radiation: an independent prognostic factor. Lung Cancer 56:105-114.
7. Chien CC, Chang CC, Yang SH, et al. (2006) A homologue of the Drosophila headcase protein, HECA, is a novel tumor marker for early-stage colorectal cancer. Oncol Rep 15:919-926.
8. Daskalaki A, Agelaki S, Perraki M, et al. (2009) Detection of cytokeratin-19 mRNA-positive cells in the peripheral blood and bone marrow of patients with operable breast cancer. Br J Cancer 101:589-597.
9. Davies RJ, Miller R, Coleman N (2005) Colorectal cancer screening: prospects for molecular stool analysis. Nat Rev Cancer 5:199-209.
10. Deshpande V, Fernandez-del Castillo C, Muzikansky A, et al. (2004) Cytokeratin 19 is a powerful predictor of survival in pancreatic endocrine tumors. Am J Surg Pathol 28:1145-1153.
11. Eschrich S, Yang I, Bloom G, et al. (2005) Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol 23:3526-3535.
12. Feng Y, Gu YL, Nie MH, et al. (2009) Study on the expression of cytokeratin 19 mRNA in oral squamous cell carcinoma. Hua Xi Kou Qiang Yi Xue Za Zhi 27:241-243.
13. Fujita Y, Terashima M, Hoshino Y, et al. (2006) Detection of cancer cells disseminated in bone marrow using real-time quantitative RT-PCR of CEA, CK19, and CK20 mRNA in patients with gastric cancer. Gastric Cancer 9:308-314.
14. Gervasoni A, Monasterio Muñoz RM, Wengler GS, et al. (2008) Molecular signature detection of circulating tumor cells using a panel of selected genes. Cancer Lett 263:267-279.
15. Giatromanolaki A, Sivridis E, Koukourakis MI (2006) Angio-genesis in colorectal cancer: prognostic and therapeutic implications. Am J Clin Oncol 29:408-417.
16. Gradilone A, Gazzaniga P, Silvestri I, et al. (2003) Detection of CK19, CK20 and EGFR mRNAs in peripheral blood of carcinoma patients: correlation with clinical stage of disease. Oncol Rep 10:217-222.
17. Haug U, Brenner H (2005) A simulation model for colorectal cancer screening: potential of stool tests with various performance characteristics compared with screening colonoscopy. Cancer Epidemiol Biomarkers Prev 14:422-428.
18. Hermanek P (1995) pTNM and residual tumor classifications: problems of assessment and prognostic significance. World J Surg 19:184-190.
19. Huang CJ, Chien CC, Yang SH, et al. (2008) Faecal ribosomal protein L19 is a genetic prognostic factor for survival in co-lorectal cancer. J Cell Mol Med 12:1936-1943.
20. Jemal A, Siegel R, Ward E, et al. (2006) Cancer statistics, 2006. CA Cancer J Clin 56:106-130.
21. Li M, Xiao ZQ, Chen ZC, et al. (2007) Proteomic analysis of the aging-related proteins in human normal colon epithelial tissue. J Biochem Mol Biol 40:72-81.
22. Mizuguchi S, Nishiyama N, Iwata T, et al. (2007) Clinical value of serum cytokeratin 19 fragment and sialyl-Lewis x in non-small cell lung cancer. Ann Thorac Surg 83:216-221.
23. Morsi MI, Youssef AI, Hassouna ME, et al. (2006) Telo-merase activity, cytokeratin 20 and cytokeratin 19 in urine cells of bladder cancer patients. J Egypt Natl Canc Inst 18:82-93.
24. Nagler R, Bahar G, Shpitzer T, et al. (2006) Concomitant analysis of salivary tumor markers\a new diagnostic tool for oral cancer. Clin Cancer Res 12:3979-3984.
25. Nozoe T, Rikimaru T, Mori E, et al. (2006) Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma. J Surg Oncol 94:132-137.
26. Pinzani P, Salvadori B, Simi L, et al. (2006) Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissection. Hum Pathol 37:711-718.
27. Ramaswamy S, Ross KN, Lander ES, et al. (2003) A molecular signature of metastasis in primary solid tumors. Nat Genet 33:49-54.
28. Sheu CC, Chang MY, Chang HC, et al. (2006) Combined detection of CEA, CK-19 and c-met mRNAs in peripheral blood: a highly sensitive panel for potential molecular diagnosis of non-small cell lung cancer. Oncology 70:203-211.
29. Silva JM, Rodriguez R, Garcia JM, et al. (2002) Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells. Gut 50:530-534.
30. Tao L, Lefevre M, Ricci S, et al. (2006) Detection of occult carci-nomatous diffusion in lymph nodes from head and neck squamous cell carcinoma using real-time RT-PCR detection of cytokeratin 19 mRNA. Br J Cancer 94:1164-1169.
31. Vogelstein B, Fearon ER, Hamilton SR, et al. (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319:525-532.
32. Wakatsuki M, Suzuki Y, Nakamoto S, et al. (2007) Clinical usefulness of CYFRA 21-1 for esophageal squamous cell carci-noma in radiation therapy. J Gastroenterol Hepatol 22:715-719.
33. Wang JY, Lin SR, Wu DC, et al. (2007) Multiple molecular markers as predictors of colorectal cancer in patients with normal perioperative serum carcinoembryonic antigen levels. Clin Cancer Res 13:2406-2413.
34. Wong IH, Yeo W, Chan AT, et al. (2001) Quantitative relationship of the circulating tumor burden assessed by reverse transcription-polymerase chain reaction for cytokeratin 19 mRNA in peripheral blood of colorectal cancer patients with Dukes' stage, serum carcinoembryonic antigen level and tumor progression. Cancer Lett 162:65-73.
35. Yang SH, Chien CC, Chen CW, et al. (2005) Potential of faecal RNA in diagnosing colorectal cancer. Cancer Lett 226:55-63.
36. Yang SH, Lin JK, Lai CR, et al. (2004) Risk factors for peritoneal dissemination of colorectal cancer. J Surg Oncol 87:167-173.
37. Zhong LP, Chen WT, Zhang CP, et al. (2007) Increased CK19 expression correlated with pathologic differentiation grade and prognosis in oral squamous cell carcinoma patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:377-384.