Enhancement of particle collection efficiency in electrohydrodynamic atomization process for pharmaceutical particle fabrication

Industrial and Engineering Chemistry Research

Volumn 49, Issue 24, 2010, Pages 12620-12631

  Rezvanpour, Alireza ^a   Attia, Amalina B E ^a   Wang, Chi Hwa ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTRICAL CONDUCTIVITY; ELECTROHYDRODYNAMIC ATOMIZATION; FREEZE-DRYING PROCESS; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; GEOMETRICAL CHARACTERISTICS; GLASS CHAMBERS; HIGH COLLECTION EFFICIENCY; MICRO-PARTICLES; NITROGEN FLOW RATES; OPERATING PARAMETERS; PARTICLE COLLECTION EFFICIENCY; PHARMACEUTICAL PARTICLES; POLYMER MATERIALS; RESIDUAL CONTENT; RESIDUAL SOLVENTS; RING VOLTAGE; SAFETY STANDARD; SOLUTION FLOW RATE; TAGUCHI; VOLTAGE DIFFERENCE;

ATOMIZATION; BIODEGRADABLE POLYMERS; DICHLOROMETHANE; ELECTRIC CONDUCTIVITY; ELECTROHYDRODYNAMICS; FABRICATION; ORGANIC SOLVENTS; POLYMERIC GLASS;

NOZZLES;

EID: 78650135125     PISSN: 08885885     EISSN: 15205045     Source Type: Journal    
DOI: 10.1021/ie1009662     Document Type: Article

References (43)

1. Almekinders, J. C.; Jones, C. Multiple jet electrohydrodynamic spraying and applications J. Aerosol Sci. 1999, 30, 969-971
2. Tatemoto, Y.; Ishikawa, R.; Takeuchi, M.; Takeshita, T.; Noda, K.; Okazaki, T. An electrospray methos using a multi-capillary nozzle emitter Chem. Eng. Technol. 2007, 30, 1274-1279
3. Hartman, R. P. A.; Brunner, D. J.; Camelot, D. M. A.; Marijnissen, J. C. M.; Scarlett, B. Electrohydrodynamic atomization in the cone-jet mode; physical moeling of the liquid cone and jet J. Aerosol Sci. 1999, 30, 823-849
4. Hayati, I.; Bailey, A. I.; Tadros, TH F. Investigations into the mechanisms of electrohydrodynamic spraying of liquids: 1. Effect of electric field and the environment on pendant drops and factors affecting the formation of stable jets and atomization J. Colloids Interf. Sci. 1987, 117, 205-221
5. Barrero, A.; Ganan-Calvo, A. M.; Fernandez-Feria, R. The role of liquid viscosity and electrical conductivity on the motions inside Taylor cones in E.H.D. spraying of liquids J. Aerosol Sci. 1996, 27, 175-176
6. Farook, U.; Zhang, H. B.; Edirisinghe, M. J.; Stride, E.; Saffari, N. Preparation of microbubble suspensions by co-axial electrohydrodynamic atomization Med. Eng. Phys. 2007, 29, 749-754
7. Lopez-Herrera, J. M.; Ganan-Calvo, A. M.; Perez-Saborid, M. One dimensional simulation of the breakup of capillary jets of conducting liquids; application to E.H.D. spraying J. Aerosol Sci. 1999, 30, 895-912
8. Lastow, O.; Balachandran, W. Novel low voltage EHD spray nozzle for atomization of water in the cone jet mode J. Electrostatics 2007, 65, 490-499
9. Noymer, P. D.; Garel, M. Stability and atomization characteristics of electrohydrodynamic jets in the cone-jet and multi-jet modes J. Aerosol Sci. 2000, 31, 1165-1172
10. Ragucci, R.; Fabiani, F.; Cavaliere, A.; Muscetta, P.; Noviello, C. Characterization of stability regimes of electrohydrodynamically enhanced atomization Exp. Therm. Fluid Sci. 2000, 21, 156-161
11. Lenggoro, I. W.; Widiyandari, H.; Hogan Jr., C. J.; Biswas, P.; Okuyama, K. Colloidal nanoparticle analysis by nanoelectrospray size spectrometry with a heated flow Anal. Chim. Acta 2007, 585, 193-201
12. Ku, B. K.; Kim, S. S. Electrohydrodynamic spraying characteristics of glycerol solutions in vacuum J. Electrostatic 2003, 57, 109-128
13. Christopher, J.; Hogan Jr.; Yun, K. M.; Chen, D. R.; Lenggoro, I. W.; Biswas, P.; Okuyama, K. Controlled size polymer particle production via electrohydrodynamic atomization Colloids Surf., A 2007, 311, 67-76
14. Wenlei, J.; Gupta, R. K.; Deshpande, M. C.; Schwendeman, S. P. Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens Adv. Drug Delivery Rev. 2005, 57, 391-410
15. Kreuter, J. Nanoparticulate systems for brain delivery of drugs Adv. Drug Delivery Rev. 2001, 47, 65-81
16. Ciach, T. Microencapsulation of drugs by electro-hydro-dynamic atomization Int. J. Pharm. 2006, 324, 51-55
17. Hong, Y.; Li, Y.; Yin, Y.; Li, D.; Zou, G. Electrohydrodynamic atomization of quasi-monodisperse drug-loaded spherical/wrinkled microparticles J. Aerosol Sci. 2008, 39, 525-536
18. Xie, J.; Marijnissen, J. C. M.; Wang, C. H. Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro Biomaterials 2006, 27, 3321-3332
19. Xie, J.; Wang, C. H. Electrospray in the dripping mode for cell microencapsulation J. Colloids Interf. Sci. 2007, 312, 247-255
20. Yao, J.; Lim, L. K.; Xie, J.; Hua, J.; Wang, C. H. Characterization of electrospraying process for polymeric particle fabrication J. Aerosol Sci. 2008, 39, 987-1002
21. Huang, Z. M.; Zhang, Y. Z.; Kotaki, M.; Ramakrishna, S. A review on polymer nanofibers by electrospinning and their applications in nanocomposites Compos. Sci. Technol. 2003, 63, 2223-2253
22. Meng, F.; Jiang, Y.; Sun, Z.; Yin, Y.; Li, Y. Electrohydrodynamic liquid atomization of biodegradable polymer microparticles: effect of electrohydrodynamic liquid atomization variables on microparticles J. Appl. Polym. Sci. 2009, 113, 526-534
23. Ijsebaert, J. C.; Geerse, K. B.; Marijnissen, J. C. M.; Lammers, J. W. J.; Zanen, P. Electro-hydrodynamic atomization of drug solutions for inhalation purposes J. Appl. Physiol. 2001, 91, 2735-2741
24. Rhodes, M. Introduction to Particle Technology; John Wiley & Sons: West Sussex, 2008.
25. Hemin, N.; Wang, C. H. Fabrication and characterization of PLGA/HAp composite scaffolds for delivery of BMP-2 plasmid DNA J. Controlled Release 2007, 120, 111-121
26. Park, S. K.; Kim, K. D.; Kim, H. T. Preparation of silica nanoparticles: Determination of the optimal synthesis conditions for small and uniform particles Colloids Surf., A 2002, 197, 7-17
27. Idris, A.; Ismail, A. F.; Noordin, M. Y.; Shilton, S. J. Optimization of cellulose acetate hollow fiber reverse osmosis membrane production using Taguchi method J. Membr. Sci. 2002, 205, 223-237
28. Rezvanpour, A.; Roostaazad, R.; Hesampour, M.; Nystrom, M.; Ghotbi, C. Effective factors in the treatment of kerosene-water emulsion by using UF membranes J. Hazardous Mat. 2009, 161, 1216-1224
29. Allen, T. Powder Sampling and Particle Size Determination; Elsevier: USA, 2003.
30. Chein, R.; Chung, J. N. Particle dynamics in a gas-particle flow over normal and inclined plates Chem. Eng. Sci. 1998, 43, 1621-1636
31. Crowe, C. T.; Troutt, T. R.; Chung, J. N.; Davis, R. W.; Moore, E. F. A Turbulent Flow without Particle Mixing Aerosol Sci. Technol. 1995, 22, 135-138
32. Huang, Y.; Wu, W.; Zhang, H. Numerical study of particle dispersion in the wake of gas-particle flows past a circular cylinder using discrete vortex method Powder Tech. 2006, 162, 73-81 (Pubitemid 43183675)
33. Yang, Y.; Chung, J. N.; Troutt, T. R.; Crowe, C. T. The effects of particles on the stability of a two-phase wake flow Int. J. Multiphase Flow 1993, 19, 137-149
34. Taguchi, G. System of Experimental Design. Engineering Methods to optimize quality and minimize costs; White Plains: New York, 1987.
35. Grace, J. M.; Marijnissen, J. C. M. A review of liquid atomization by electrical means J. Aerosol Sci. 1994, 25, 1005-1019
36. Hartman, R. P. A.; Brunner, D. J.; Camelot, D. M. A.; Marijnissen, J. C. M.; Scarlett, B. Jet break-up in electrohydrodynamic atomization in the cone-jet mode J. Aerosol Sci. 2000, 31, 65-95
37. Cloupeau, M.; Prunet-Foch, B. Electrohydrodynamic spraying functioning modes: a critical review J. Aerosol Sci. 1994, 25, 1021-1036
38. Lindblad, N. R.; Schneider, J. M. Production of uniform-sized liquid droplets J. Sci. Instrum. 1965, 42, 635-638
39. Borra, J. P.; Hartmann, R.; Marijnissen, J.; Scarlett, B. Destabilisation of sprays in the cone-jet mode by electrical discharges on the jet J. Aerosol Sci. 1996, 27, 203-204
40. Ding, L.; Lee, T.; Wang, C. H. Fabrication of monodispersed Taxol-loaded particles using electrohydrodynamic atomization J. Controlled Release 2005, 102, 395-413
41. Xie, J.; Lim, L. K.; Phua, Y.; Hua, J.; Wang, C. H. Electrohydrodynamic atomization for biodegradable polymeric particle production J. Colloids Interf. Sci. 2006, 302, 103-112
42. Ciach, T. Application of Electro-hydro-dynamic Atomization in Drug Delivery J. Drug Deliv. Sci. Tech. 2007, 17, 367-375
43. Burgarski, B.; Amsden, B.; Neufeld, R. J.; Poncelet, D.; Goosen, M. F. A. Effect of electrode geometry and charge on the production of polymer microbeads by electrostatics Can. J. Chem. Eng. 1994, 72, 517-521