Recent history of vasovagal syncope in a young, referral-based population is a stronger predictor of recurrent syncope than lifetime syncope burden

Journal of Cardiovascular Electrophysiology

Volumn 21, Issue 12, 2010, Pages 1375-1380

  Sumner, Glen L ^a   Rose, M Sarah ^a   Koshman, Mary Lou ^a   Ritchie, Debbie ^a   Sheldon, Robert S ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

head up tilt test; natural history; neurally mediated syncope; prognosis; vasovagal syncope

Indexed keywords

ADULT; ARTICLE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT REFERRAL; PRIORITY JOURNAL; RECURRENT DISEASE; RISK FACTOR; SYNCOPE; TILT TABLE TEST;

ADULT; AGE FACTORS; COST OF ILLNESS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RECURRENCE; REFERRAL AND CONSULTATION; SYNCOPE; SYNCOPE, VASOVAGAL; TILT-TABLE TEST; TIME FACTORS;

EID: 78650112365     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2010.01848.x     Document Type: Article

References (25)

1. Connolly SJ, Sheldon R, Roberts RS, Gent M,: The North American Vasovagal Pacemaker Study (VPS). A randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope. J Am Coll Cardiol 1999; 33: 16-20.
2. Raj SR, Rose S, Ritchie D, Sheldon RS,: The Second Prevention of Syncope Trial (POST II)-a randomized clinical trial of fludrocortisone for the prevention of neurally mediated syncope: Rationale and study design. Am Heart J 2006; 151: 1186 e11-1186 e17.
3. Sheldon R, Rose S,: Components of clinical trials for vasovagal syncope. Europace 2001; 3: 233-240.
4. Sheldon R, Connolly S, Rose S, Klingenheben T, Krahn A, Morillo C, Talajic M, Ku T, Fouad-Tarazi F, Ritchie D, Koshman ML,: Prevention of Syncope Trial (POST): A randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope. Circulation 2006; 113: 1164-1170.
5. Raviele A, Giada F, Sutton R, Alboni P, Brignole M, Del Rosso A, Di Girolamo E, Luise R, Menozzi C,: The vasovagal Syncope and pacing (Synpace) trial: Rationale and study design. Europace 2001; 3: 336-341.
6. Raviele A, Brignole M, Sutton R, Alboni P, Giani P, Menozzi C, Moya A,: Effect of etilefrine in preventing syncopal recurrence in patients with vasovagal syncope: A double-blind, randomized, placebo-controlled trial. The Vasovagal Syncope International Study. Circulation 1999; 99: 1452-1457.
7. Kaufmann H, Saadia D, Voustianiouk A,: Midodrine in neurally mediated syncope: A double-blind, randomized, crossover study. Ann Neurol 2002; 52: 342-345.
8. Connolly SJ, Sheldon R, Thorpe KE, Roberts RS, Ellenbogen KA, Wilkoff BL, Morillo C, Gent M,: Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: Second Vasovagal Pacemaker Study (VPS II): A randomized trial. JAMA 2003; 289: 2224-2229.
9. Brignole M,: International study on syncope of uncertain aetiology 3 (ISSUE 3): Pacemaker therapy for patients with asystolic neurally-mediated syncope: Rationale and study design. Europace 2007; 9: 25-30.
10. Brignole M, Sutton R, Menozzi C, Garcia-Civera R, Moya A, Wieling W, Andresen D, Benditt DG, Vardas P,: Early application of an implantable loop recorder allows effective specific therapy in patients with recurrent suspected neurally mediated syncope. Eur Heart J 2006; 27: 1085-1092.
11. Ammirati F, Colivicchi F, Santini M,: Permanent cardiac pacing versus medical treatment for the prevention of recurrent vasovagal syncope: A multicenter, randomized, controlled trial. Circulation 2001; 104: 52-57.
12. Benditt DG, Petersen M, Lurie KG, Grubb BP, Sutton R,: Cardiac pacing for prevention of recurrent vasovagal syncope. Ann Intern Med 1995; 122: 204-209.
13. Flevari P, Livanis EG, Theodorakis GN, Zarvalis E, Mesiskli T, Kremastinos DT,: Vasovagal syncope: A prospective, randomized, crossover evaluation of the effect of propranolol, nadolol and placebo on syncope recurrence and patients' well-being. J Am Coll Cardiol 2002; 40: 499-504.
14. Raviele A, Giada F, Menozzi C, Speca G, Orazi S, Gasparini G, Sutton R, Brignole M,: A randomized, double-blind, placebo-controlled study of permanent cardiac pacing for the treatment of recurrent tilt-induced vasovagal syncope. The vasovagal syncope and pacing trial (SYNPACE). Eur Heart J 2004; 25: 1741-1748.
15. Grimm W, Degenhardt M, Hoffman J, Menz V, Wirths A, Maisch B,: Syncope recurrence can better be predicted by history than by head-up tilt testing in untreated patients with suspected neurally mediated syncope. Eur Heart J 1997; 18: 1465-1469.
16. Malik P, Koshman ML, Sheldon R,: Timing of first recurrence of syncope predicts syncopal frequency after a positive tilt table test result. J Am Coll Cardiol 1997; 29: 1284-1289.
17. Raj SR, Koshman ML, Sheldon RS,: Outcome of patients with dual-chamber pacemakers implanted for the prevention of neurally mediated syncope. Am J Cardiol 2003; 91: 565-569.
18. Grambsch PM, Therneau TM,: Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994; 81: 515-526.
19. Sheldon RS, Sheldon AG, Connolly SJ, Morillo CA, Klingenheben T, Krahn AD, Koshman ML, Ritchie D,: Age of first faint in patients with vasovagal syncope. J Cardiovasc Electrophysiol 2006; 17: 49-54.
20. Sheldon RS, Sheldon AG, Serletis A, Connolly SJ, Morillo CA, Klingenheben T, Krahn AD, Koshman ML, Ritchie D,: Worsening of symptoms before presentation with vasovagal syncope. J Cardiovasc Electrophysiol 2007; 18: 954-959.
21. Madrid AH, Ortega J, Rebollo JG, Manzano JG, Segovia JG, Sanchez A, Pena G, Moro C,: Lack of efficacy of atenolol for the prevention of neurally mediated syncope in a highly symptomatic population: A prospective, double-blind, randomized and placebo-controlled study. J Am Coll Cardiol 2001; 37: 554-559.
22. Sutton R, Brignole M, Menozzi C, Raviele A, Alboni P, Giani P, Moya A,: Dual-chamber pacing in the treatment of neurally mediated tilt-positive cardioinhibitory syncope: Pacemaker versus no therapy: A multicenter randomized study. The Vasovagal Syncope International Study (VASIS) Investigators. Circulation 2000; 102: 294-299.
23. Sheldon R, Rose S, Flanagan P, Koshman ML, Killam S,: Risk factors for syncope recurrence after a positive tilt-table test in patients with syncope. Circulation 1996; 93: 973-981.
24. Baron-Esquvias G EF, Pedrote A, Cayuela A, Gomez S, Aguilera A, Campos A, Fernandez M, Valle J, Redondo M, Fernandez JM, Martinez A, Burgos J, Martinez-Rubio A,: Long term outcome of patients with vasovagal syncope. Am Heart J 2004: 883-889.
25. Grubb BP,: Once a fainter, always a fainter? J Cardiovasc Electrophysiol 2006; 17: 55.