Pacemaker Therapy for Prevention of Syncope in Patients with Recurrent Severe Vasovagal Syncope: Second Vasovagal Pacemaker Study (VPS 11): A Randomized Trial

JAMA

Volumn 289, Issue 17, 2003, Pages 2224-2229

  Connolly, Stuart J ^a,f   Sheldon, Robert ^b   Thorpe, Kevin E ^a   Roberts, Robin S ^a   Ellenbogen, Kenneth A ^c   Wilkoff, Bruce L ^d   Morillo, Carlos ^a,e   Gent, Michael ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e Instituto del Corazon   (Colombia)

^f NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DISOPYRAMIDE; FLUDROCORTISONE; PHENYLEPHRINE; SEROTONIN UPTAKE INHIBITOR;

ADULT; ARTICLE; ARTIFICIAL HEART PACEMAKER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEART TAMPONADE; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK MANAGEMENT; SYNCOPE; TREATMENT OUTCOME; VEIN THROMBOSIS; AGED; BRADYCARDIA; DOUBLE BLIND PROCEDURE; MIDDLE AGED; MULTICENTER STUDY; PROPORTIONAL HAZARDS MODEL; RECURRENT DISEASE;

ADULT; AGED; BRADYCARDIA; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PACEMAKER, ARTIFICIAL; PROPORTIONAL HAZARDS MODELS; RECURRENCE; SYNCOPE, VASOVAGAL;

EID: 0037809703     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.289.17.2224     Document Type: Article

References (11)

1. Benditt DG, Petersen M, Lurie KG, Sutton R. Cardiac pacing for the prevention of recurrent vasovagal syncope. Ann Intern Med. 1995;122:204-209.
2. Fitzpatrick A, Theodorakis G, Ahmed R, Williams T, Sutton R. Dual chamber pacing aborts vasovagal syncope induced by head-up 60° tilt. Pacing Clin Electrophysiol. 1991;14:13-19.
3. Connolly SJ, Sheldon R, Roberts RS, Gent M. The North American Vasovagal Pacemaker Study (VPS). J Am Coll Cardiol. 1999;33:16-20.
4. Sutton R, Brignole M, Menozzi C, et al. Dual chamber pacing in the treatment of neurally mediated tilt-positive cardioinhibitory syncope. Circulation. 2000;102:294-299.
5. Ammirati F, Colvicchi F, Santini M. Permanent cardiac pacing versus medical treatment for the prevention of recurrent vasovagal syncope. Circulation. 2001;104:52-57.
6. Moerman DE, Jonas WB. Deconstructing the placebo effect and finding the meaning response. Ann Intern Med. 2002;136:471-476.
7. Beecher HK. Surgery as placebo. JAMA. 1961;176:1102-1107.
8. Kaptchuk TJ, Goldman P, Stone DA, Stason WB. Do medical devices have placebo effects? J Clin Epidemiol. 2000;53:786-792.
9. Morillo CA, Eckberg DL, Ellenbogen KA, et al. Vagal and sympathetic mechanisms in patients with orthostatic vasovagal syncope. Circulation. 1997;96:2509-2513.
10. Mosqueda-Garcia R, Furlan R, Fernandez-Violante R, et al. Sympathetic and baroreceptor reflex function in neurally mediated syncope evoked by tilt. J Clin Invest. 1997;99:2736-2744.
11. Horng S, Miller FG. Is placebo surgery ethical? N Engl J Med. 2002;347:137-139.