Evaluation of hydroxypropyl methylcellulose matrix systems as swellable gastro-retentive drug delivery systems (GRDDS)

Journal of Pharmaceutical Sciences

Volumn 100, Issue 1, 2011, Pages 150-163

  Matharu, Amol S ^a   Motto, Michael G ^b   Patel, Mahendra R ^c   Simonelli, Anthony P ^a   Dave, Rutesh H ^a  

^a LONG ISLAND UNIVERSITY   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Navinta LLC   (United States)

Author keywords

Controlled release; Diffusion; Dissolution; Formulation; Gastrointestinal transit; Hydrogels; Mathematical model; Oral drug delivery; Polymers; Solid dispersion

Indexed keywords

COPOVIDONE; DIPYRIDAMOLE; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; MAGNESIUM STEARATE; MANNITOL; MICROCRYSTALLINE CELLULOSE; POLYMER; POVIDONE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DOSAGE FORM COMPARISON; DRUG SOLUBILITY; GASTRO RETENTIVE DRUG DELIVERY SYSTEM; WETTABILITY;

EID: 78650073841     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22252     Document Type: Article

References (22)

1. Russell TL, Berardi RR, Barnett JL, O'Sullivan TL, Wagner JG, Dressman JB. 1994. pH-related changes in the absorption of dipyridamole in the elderly. Pharm Res 11: 136-143.
2. Grundy JS, Foster RT. 1996. The nifedipine gastrointestinal therapeutic system (GITS). Evaluation of pharmaceutical, pharmacokinetic and pharmacological properties. Clin Pharmacokinet 30: 28-51.
3. Varma MV, Kaushal AM, Garg S. 2005. Influence of micro-environmental pH on the gel layer behavior and release of a basic drug from various hydrophilic matrices. J Control Release 103: 499-510.
4. Johnson KC, Swindell AC. 1996. Guidance in the setting of drug particle size specifications to minimize variability in absorption. Pharm Res 13: 1795-1798.
5. Hoffman A, Qadri BA. 2006. Gastro-retentive systems. In: Swarbick J, editor. Encyclopedia of pharmaceutical technology. 3rd edition. New York: Marcel Dekker. pp 1850-1860.
6. Hogan JE. 1989. Hydroxypropylmethylcellulose sustained release technology. Drug Dev Ind Pharm 15: 975-999.
7. Vázquez MJ, Pérez-Marcos B, Gómez-Amoza JL, Pacheco Ri, Souto C, Concheiro A. 1992. Influence of technological variables on release of drugs from hydrophilic matrices. Drug Dev Ind Pharm 18: 1355-1375.
8. Timmermans J, Moes AJ. 1993. The cutoff size for gastric emptying of dosage forms. J Pharm Sci 82: 854.
9. Tahara K, Yamamoto K, Nishihata T. 1995. Overall mechanism behind matrix sustained release (SR) tablets prepared with hydroxypropyl methylcellulose 2910. J Control Release 35: 59-66.
10. Sai Cheong Wan L, Wan Sia Heng P, Fun Wong L. 1995. Matrix swelling: A simple model describing extent of swelling of HPMC matrices. Int J Pharm 116: 159-168.
11. Skoug JW, Mikelsons MV, Vigneron CN, Stemm NL. 1993. Qualitative evaluation of the mechanism of release of matrix sustained release dosage forms by measurement of polymer release. J Control Release 27: 227-245.
12. Katzhendler I, Hoffman A, Goldberger A, Friedman M. 1997. Modeling of drug release from erodible tablets. J Pharm Sci 86: 110-115.
13. Colombo P, Bettini R, Santi P, De Ascentiis A, Peppas NA. 1996. Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport. J Control Release 39: 231-237.
14. Bettini R, Catellani PL, Santi P, Massimo G, Peppas NA, Colombo P. 2001. Translocation of drug particles in HPMC matrix gel layer: Effect of drug solubility and influence on release rate. J Control Release 70: 383-391.
15. Higuchi T. 1963. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 52: 1145-1149.
16. Ritger PL, Peppas NA. 1987. A simple equation for description of solute release I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J Control Release 5: 23-36.
17. Russell TL, Berardi RR, Barnett JL, Dermentzoglou LC, Jarvenpaa KM, Schmaltz SP, Dressman JB. 1993. Upper gastrointestinal pH in seventy-nine healthy, elderly, North American men and women. Pharm Res 10: 187-196.
18. Kohri N, Miyata N, Takahashi M, Endo H, Iseki K, Miyazaki K, Takechi S, Nomura A. 1992. Evaluation of pH-independent sustained-release granules of dipyridamole by using gastric-acidity-controlled rabbits and human subjects. Int J Pharm 81: 49-58.
19. Ritger PL, Peppas NA. 1987. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release 5: 37-42.
20. Peppas NA, Sahlin JJ. 1989. A simple equation for the description of solute release. III. Coupling of diffusion and relaxation. Int J Pharm 57: 169-172.
21. Yamaoka K, Nakagawa T, Uno T. 1978. Application of the Akaike information criterion (AIC) in the evaluation of linear pharmacokinetics equations. J Pharmacokinet Biopharm 6: 165-175.
22. Cao QR, Choi YW, Cui JH, Lee BJ. 2005. Formulation, release characteristics and bioavailability of novel monolithic hydroxypropylmethylcellulose matrix tablets containing acetaminophen. J Control Release 108: 351-361.