Formulation, release characteristics and bioavailability of novel monolithic hydroxypropylmethylcellulose matrix tablets containing acetaminophen

Journal of Controlled Release

Volumn 108, Issue 2-3, 2005, Pages 351-361

  Cao, Qing Ri ^a,c   Choi, Yun Woong ^a,b   Cui, Jing Hao ^c   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

^b Seoul Pharma Co Ltd   (South Korea)

^c YANBIAN UNIVERSITY   (China)

Author keywords

Bilayered tablet; Bioavailability; Dual release; Monolithic HPMC matrix tablet; Swelling mechanism

Indexed keywords

DISSOLUTION; DRUG PRODUCTS; GASTROENTEROLOGY; GELS; PH EFFECTS;

BILAYERED TABLET; BIOAVAILABILITY; DUAL RELEASE; MONOLITHIC HPMC MATRIX TABLET; SWELLING MECHANISM;

DRUG DOSAGE;

AC-DI-SOL; AEROSIL; DODECYL SULFATE SODIUM; EXCIPIENT; HYDROXYPROPYLMETHYLCELLULOSE; MICROCRYSTALLINE CELLULOSE; PARACETAMOL; POLIDOCANOL; PREJEL; SODIUM DIHYDROGEN PHOSPHATE; STARCH GLYCOLATE SODIUM; WATER;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG GRANULATION; DRUG SOLUBILITY; EXTENDED DRUG RELEASE; GEL; HUMAN; IN VITRO STUDY; INTESTINE FLUID; MOLECULAR INTERACTION; NORMAL HUMAN; PRIORITY JOURNAL; STOMACH JUICE; TABLET; TABLET COMPRESSION;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; HUMANS; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; KINETICS; LACTOSE; MALE; METHYLCELLULOSE; OXAZINES; SOLUBILITY; SURFACE-ACTIVE AGENTS; TABLETS; WATER;

EID: 27744599576     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.08.004     Document Type: Article

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