Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex

Journal of General Virology

Volumn 91, Issue 12, 2010, Pages 3010-3015

  Mo, Min ^a   Fleming, Stephen B ^a   Mercer, Andrew A ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; POXVIRUS ANAPHASE PROMOTING COMPLEX REGULATOR PROTEIN; PROTEIN SUBUNIT; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CELL CYCLE; CELL CYCLE REGULATION; MOLECULAR INTERACTION; NONHUMAN; POXVIRUS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; VIRUS REPLICATION;

BLOTTING, WESTERN; CYTOSKELETAL PROTEINS; HOST-PATHOGEN INTERACTIONS; IMMUNOPRECIPITATION; ORF VIRUS; PROTEIN BINDING; UBIQUITIN-PROTEIN LIGASE COMPLEXES; VIRAL PROTEINS;

ORF VIRUS; POXVIRIDAE;

EID: 78650052569     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.026054-0     Document Type: Article

References (15)

1. Bellanger, S., Blachon, S., Mechali, F., Bonne-Andrea, C. & Thierry, F. (2005). High-risk but not low-risk HPV E2 proteins bind to the APC activators Cdh1 and Cdc20 and cause genomic instability. Cell Cycle 4, 1608-1615.
2. Heilman, D. W., Teodoro, J. G. & Green, M. R. (2006). Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies. J Virol 80, 7535-7545.
3. Kim, S., Park, S. Y., Yong, H., Famulski, J. K., Chae, S., Lee, J. H., Kang, C. M., Saya, H., Chan, G. K. & Cho, H. (2008). HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint. Oncogene 27, 3457-3464.
4. Liu, B., Hong, S., Tang, Z., Yu, H. & Giam, C. Z. (2005). HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule. Proc Natl Acad Sci U S A 102, 63-68.
5. Mo, M., Fleming, S. B. & Mercer, A. A. (2009). Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11. Proc Natl Acad Sci U S A 106, 19527-19532.
6. Mo, M., Fleming, S. B. & Mercer, A. A. (2010). Changing pace: viral mimicry of an anaphase promoting complex subunit. Cell Cycle 9, 632-633.
7. Mui, M. Z., Roopchand, D. E., Gentry, M. S., Hallberg, R. L., Vogel, J. & Branton, P. E. (2010). Adenovirus protein E4orf4 induces premature APCCdc20 activation in Saccharomyces cerevisiae by a protein phosphatase 2A-dependent mechanism. J Virol 84, 4798-4809.
8. Ohta, T., Michel, J. J. & Xiong, Y. (1999). Association with cullin partners protects ROC proteins from proteasome-dependent degradation. Oncogene 18, 6758-6766.
9. Tang, Z., Li, B., Bharadwaj, R., Zhu, H., Ozkan, E., Hakala, K., Deisenhofer, J. & Yu, H. (2001). APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol Biol Cell 12, 3839-3851. (Pubitemid 34001077)
10. Teodoro, J. G., Heilman, D. W., Parker, A. E. & Green, M. R. (2004). The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53. Genes Dev 18, 1952-1957.
11. Thornton, B. R., Ng, T. M., Matyskiela, M. E., Carroll, C. W., Morgan, D. O. & Toczyski, D. P. (2006). An architectural map of the anaphase-promoting complex. Genes Dev 20, 449-460.
12. Tran, K., Mahr, J. A., Choi, J., Teodoro, J. G., Green, M. R. & Spector, D. H. (2008). Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits. J Virol 82, 529-537. (Pubitemid 350309167)
13. Turnell, A. S., Stewart, G. S., Grand, R. J., Rookes, S. M., Martin, A., Yamano, H., Elledge, S. J. & Gallimore, P. H. (2005). The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. Nature 438, 690-695. (Pubitemid 41740581)
14. van Leuken, R., Clijsters, L. & Wolthuis, R. (2008). To cell cycle, swing the APC/C. Biochim Biophys Acta 1786, 49-59.
15. Wiebusch, L., Bach, M., Uecker, R. & Hagemeier, C. (2005). Human cytomegalovirus inactivates the G0/G1-APC/C ubiquitin ligase by Cdh1 dissociation. Cell Cycle 4, 1435-1439. (Pubitemid 41437135)