Opposite effects of transforming growth factor-β1 and vascular endothelial growth factor on the degeneration of aortic valvular interstitial cell are modified by the extracellular matrix protein fibronectin: Implications for heart valve engineering

Tissue Engineering - Part A

Volumn 16, Issue 12, 2010, Pages 3737-3746

  Gwanmesia, Patricia ^a   Ziegler, Heiko ^a   Eurich, Rosa ^a   Barth, Mareike ^b   Kamiya, Hiroyuki ^c   Karck, Matthias ^a   Lichtenberg, Artur ^c   Akhyari, Payam ^c  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMINERALIZATION; BLOOD VESSELS; BONE; CELL DEATH; COATINGS; COLLAGEN; ENZYME INHIBITION; SELF ASSEMBLY; TISSUE ENGINEERING;

APOPTOSIS; APOPTOTIC; DEAD CELLS; ECM PROTEINS; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX PROTEIN; GROWTH FACTOR; HEART VALVES; LAMININ; PROTECTIVE EFFECTS; SCAFFOLDS FOR TISSUE ENGINEERING; TRANSFORMING GROWTH FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

PEPTIDES;

OVIS;

FIBRONECTIN; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN A;

ANIMAL; AORTA VALVE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; HEART VALVE; METABOLISM; METHODOLOGY; POLYMERASE CHAIN REACTION; SHEEP; TISSUE ENGINEERING; WESTERN BLOTTING;

ANIMALS; AORTIC VALVE; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; EXTRACELLULAR MATRIX PROTEINS; FIBRONECTINS; HEART VALVES; POLYMERASE CHAIN REACTION; SHEEP; TISSUE ENGINEERING; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78650038782     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2010.0304     Document Type: Article

References (20)

1. Lichtenberg, A., Tudorache, I., Cebotari, S., Suprunov, M., Tudorache, G., Goerler, H., et al. Preclinical testing of tissue-engineered heart valves re-endothelialized under simulated physiological conditions. Circulation 114, I559, 2006.
2. Lichtenberg, A., Cebotari, S., Tudorache, I., Sturz, G., Winterhalter, M., Hilfiker, A., et al. Flow-dependent re-endothelialization of tissue-engineered heart valves. J Heart Valve Dis 15, 287; discussion 293, 2006.
3. Akhyari, P., Kamiya, H., Mambou, P., Ziegler, H., Barth, M., Tschierschke, R., et al. In vivo endothelialisation of allogenic detergent decellularized heart valves can be enhanced by surface coating using autologous fibrin. Presented at the 56th Annual Meeting of Southern Thoracic Surgical Association, Marco Island, FL, 2009.
4. Akhyari, P., Kamiya, H., Haverich, A., Karck, M., and Lichtenberg, A. Myocardial tissue engineering: the extracellular matrix. Eur J Cardiothorac Surg 34, 229, 2008.
5. Mann, B.K., Schmedlen, R.H., and West, J.L. Tethered-TGF-beta increases extracellular matrix production of vascular smooth muscle cells. Biomaterials 22, 439, 2001.
6. Akat, K., Borggrefe, M., and Kaden, J.J. Aortic valve calcification: basic science to clinical practice. Heart 95, 616, 2009.
7. Butany, J., and Leask, R. The failure modes of biological prosthetic heart valves. J Long Term Eff Med Implants 11, 115, 2001.
8. Jian, B., Narula, N., Li, Q.Y., Mohler, E.R., 3rd, and Levy, R.J. Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann Thorac Surg 75, 457; discussion 465, 2003.
9. Clark-Greuel, J.N., Connolly, J.M., Sorichillo, E., Narula, N.R., Rapoport, H.S., Mohler, E.R., 3rd, et al. Transforming growth factor-beta1 mechanisms in aortic valve calcification: Increased alkaline phosphatase and related events. Ann Thorac Surg 83, 946, 2007.
10. Soini, Y., Salo, T., and Satta, J. Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis. Hum Pathol 34, 756, 2003.
11. Korkmaz, S., Radovits, T., Barnucz, E., Hirschberg, K., Neugebauer, P., Loganathan, S., et al. Pharmacological activation of soluble guanylate cyclase protects the heart against ischemic injury. Circulation 120, 677, 2009.
12. Paruchuri, S., Yang, J.H., Aikawa, E., Melero-Martin, J.M., Khan, Z.A., Loukogeorgakis, S., et al. Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-a and transforming growth factor-beta2. Circ Res 99, 861, 2006.
13. Barth M., Schumacher, H., Kuhn, C., Akhyari, P., Lichten-berg, A., and Franke, W.W. Cordial connections: molecular ensembles and structures of adhering junctions connecting interstitial cells of cardiac valves in situ and in cell culture. Cell Tissue Res 337 63 2009.
14. Akhyari, P., Kamiya, H., Mambou, P., Barth, M., Romeike, B., Aubin, H., et al. Impact of protein coating strategies on the re-endothelialization of biological heart valve scaffolds. Presented at the 38th Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery, Stuttgart, Germany, 2009.
15. Watson, K.E., Bostrom, K., Ravindranath, R., Lam, T., Norton, B., and Demer, L.L. TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest 93, 2106, 1994.
16. Rodriguez, K.J., and Masters, K.S. Regulation of valvular interstitial cell calcification by components of the extracellular matrix. J Biomed Mater Res A 90, 1043, 2009.
17. Gu, X., and Masters, K.S. Regulation of valvular interstitial cell calcification by adhesive peptide sequences. J Biomed Mater Res A 93, 1620, 2010.
18. Ferrara, N., and Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 18, 4, 1997.
19. Benton, J.A., Kern, H.B., and Anseth, K.S. Substrate properties influence calcification in valvular interstitial cell culture. J Heart Valve Dis 17, 689, 2008.
20. Cushing, M.C., Liao, J.T., and Anseth, K.S. Activation of valvular interstitial cells is mediated by transforming growth factor-beta1 interactions with matrix molecules. Matrix Biol 24, 428, 2005.