-
1
-
-
0025141337
-
What is the evidence that tumors are angiogenesis dependent?
-
Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990; 82: 4-6.
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 4-6
-
-
Folkman, J.1
-
2
-
-
67651042798
-
Paracrine action of sFLT-1 secreted by stably transfected Ehrlich ascites tumor cells and therapy using sFLT-1 inhibits ascites tumor growth in vivo
-
Ramachandra S, D'Souza SS, Gururaj AE, Shaila MS, Salimath BP. Paracrine action of sFLT-1 secreted by stably transfected Ehrlich ascites tumor cells and therapy using sFLT-1 inhibits ascites tumor growth in vivo. J Gene Med 2009; 11: 422-434.
-
(2009)
J Gene Med
, vol.11
, pp. 422-434
-
-
Ramachandra, S.1
D'Souza, S.S.2
Gururaj, A.E.3
Shaila, M.S.4
Salimath, B.P.5
-
3
-
-
0035294634
-
General aspects of antiangiogenesis and cancer therapy
-
Zogakis TG, Libutti SK. General aspects of antiangiogenesis and cancer therapy. Expert Opin Biol Ther 2001; 1: 253-275.
-
(2001)
Expert Opin Biol Ther
, vol.1
, pp. 253-275
-
-
Zogakis, T.G.1
Libutti, S.K.2
-
4
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427-434.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
5
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
6
-
-
0029863730
-
Dominant negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo
-
Millauer B, Longhi MP, Plate KH, et al. Dominant negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo. Cancer Res 1996; 56: 1615-1620.
-
(1996)
Cancer Res
, vol.56
, pp. 1615-1620
-
-
Millauer, B.1
Longhi, M.P.2
Plate, K.H.3
-
7
-
-
13144262858
-
Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate
-
Goldman CK, Kendall RL, Cabrera G, et al. Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate. Proc Natl Acad Sci USA 1998; 95: 8795-8800.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8795-8800
-
-
Goldman, C.K.1
Kendall, R.L.2
Cabrera, G.3
-
8
-
-
0032889726
-
Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development
-
Partanen J, Dumont DJ. Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development. Curr Top Microbiol Immunol 1999; 237: 159-172.
-
(1999)
Curr Top Microbiol Immunol
, vol.237
, pp. 159-172
-
-
Partanen, J.1
Dumont, D.J.2
-
9
-
-
0027191251
-
The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors
-
Dumont DJ, Gradwohl GJ, Fong GH, Auerbach R, Breitman ML. The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors. Oncogene 1993; 8: 1293-1302.
-
(1993)
Oncogene
, vol.8
, pp. 1293-1302
-
-
Dumont, D.J.1
Gradwohl, G.J.2
Fong, G.H.3
Auerbach, R.4
Breitman, M.L.5
-
10
-
-
0027326213
-
Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells
-
Iwama A, Hamaguchi I, Hashiyama M, Murayama Y, Yasunaga K, Suda T. Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells. Biochem Biophys Res Commun 1993; 195: 301-309.
-
(1993)
Biochem Biophys Res Commun
, vol.195
, pp. 301-309
-
-
Iwama, A.1
Hamaguchi, I.2
Hashiyama, M.3
Murayama, Y.4
Yasunaga, K.5
Suda, T.6
-
11
-
-
0027515802
-
Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage
-
Schnurch H, Risau W. Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage. Development 1993; 119: 957-968.
-
(1993)
Development
, vol.119
, pp. 957-968
-
-
Schnurch, H.1
Risau, W.2
-
12
-
-
0029015923
-
Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
-
Dumont DJ, Fong GH, Puri MC, Gradwohl G, Alitalo K, Breitman ML. Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development. Dev Dyn 1995; 203: 80-92.
-
(1995)
Dev Dyn
, vol.203
, pp. 80-92
-
-
Dumont, D.J.1
Fong, G.H.2
Puri, M.C.3
Gradwohl, G.4
Alitalo, K.5
Breitman, M.L.6
-
13
-
-
0030053429
-
Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells
-
Rodewald HR, Sato TN. Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells. Oncogene 1996; 12: 397-404.
-
(1996)
Oncogene
, vol.12
, pp. 397-404
-
-
Rodewald, H.R.1
Sato, T.N.2
-
14
-
-
0029001244
-
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
-
Sato TN, Tozawa Y, Deutsch U, et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 1995; 376: 70-74.
-
(1995)
Nature
, vol.376
, pp. 70-74
-
-
Sato, T.N.1
Tozawa, Y.2
Deutsch, U.3
-
15
-
-
35648952161
-
Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2
-
Marron MB, Singh H, Tahir TA, et al. Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. J Biol Chem 2007; 282: 30509-30517.
-
(2007)
J Biol Chem
, vol.282
, pp. 30509-30517
-
-
Marron, M.B.1
Singh, H.2
Tahir, T.A.3
-
16
-
-
33646780950
-
Signaling and functions of angiopoietin-1 in vascular protection
-
Brindle NP, Saharinen P, Alitalo K. Signaling and functions of angiopoietin-1 in vascular protection. Circ Res 2006; 98: 1014-1023.
-
(2006)
Circ Res
, vol.98
, pp. 1014-1023
-
-
Brindle, N.P.1
Saharinen, P.2
Alitalo, K.3
-
17
-
-
43049116513
-
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts
-
Saharinen P, Eklund L, Miettinen J, et al. Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol 2008; 10: 527-537.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 527-537
-
-
Saharinen, P.1
Eklund, L.2
Miettinen, J.3
-
18
-
-
18544365981
-
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2
-
Saharinen P, Kerkela K, Ekman N, et al. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J Cell Biol 2005; 169: 239-243.
-
(2005)
J Cell Biol
, vol.169
, pp. 239-243
-
-
Saharinen, P.1
Kerkela, K.2
Ekman, N.3
-
19
-
-
35248867961
-
Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival
-
Yuan HT, Venkatesha S, Chan B, et al. Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival. FASEB J 2007; 21: 3171-3183.
-
(2007)
FASEB J
, vol.21
, pp. 3171-3183
-
-
Yuan, H.T.1
Venkatesha, S.2
Chan, B.3
-
20
-
-
33344477298
-
Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling
-
Eklund L, Olsen BR. Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. Exp Cell Res 2006; 312: 630-641.
-
(2006)
Exp Cell Res
, vol.312
, pp. 630-641
-
-
Eklund, L.1
Olsen, B.R.2
-
21
-
-
15144358851
-
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
-
Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277: 55-60.
-
(1997)
Science
, vol.277
, pp. 55-60
-
-
Maisonpierre, P.C.1
Suri, C.2
Jones, P.F.3
-
22
-
-
0030851764
-
Signaling vascular morphogenesis and maintenance
-
Hanahan D. Signaling vascular morphogenesis and maintenance. Science 1997; 277: 48-50.
-
(1997)
Science
, vol.277
, pp. 48-50
-
-
Hanahan, D.1
-
24
-
-
0033588842
-
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
-
Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 1999; 18: 5356-5362.
-
(1999)
Oncogene
, vol.18
, pp. 5356-5362
-
-
Holash, J.1
Wiegand, S.J.2
Yancopoulos, G.D.3
-
25
-
-
0034036689
-
Angiopoietin-1 protects the adult vasculature against plasma leakage
-
Thurston G, Rudge JS, Ioffe E, et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 2000; 6: 460-463.
-
(2000)
Nat Med
, vol.6
, pp. 460-463
-
-
Thurston, G.1
Rudge, J.S.2
Ioffe, E.3
-
26
-
-
0034648793
-
Vascular-specific growth factors and blood vessel formation
-
Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature 2000; 407: 242-248.
-
(2000)
Nature
, vol.407
, pp. 242-248
-
-
Yancopoulos, G.D.1
Davis, S.2
Gale, N.W.3
Rudge, J.S.4
Wiegand, S.J.5
Holash, J.6
-
27
-
-
0030764063
-
Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues
-
Wong AL, Haroon ZA, Werner S, Dewhirst MW, Greenberg CS, Peters KG. Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circ Res 1997; 81: 567-574.
-
(1997)
Circ Res
, vol.81
, pp. 567-574
-
-
Wong, A.L.1
Haroon, Z.A.2
Werner, S.3
Dewhirst, M.W.4
Greenberg, C.S.5
Peters, K.G.6
-
28
-
-
0031964710
-
Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis
-
Peters KG, Coogan A, Berry D, et al. Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis. Br J Cancer 1998; 77: 51-56.
-
(1998)
Br J Cancer
, vol.77
, pp. 51-56
-
-
Peters, K.G.1
Coogan, A.2
Berry, D.3
-
29
-
-
0031737425
-
Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis
-
Stratmann A, Risau W, Plate KH. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. Am J Pathol 1998; 153: 1459-1466.
-
(1998)
Am J Pathol
, vol.153
, pp. 1459-1466
-
-
Stratmann, A.1
Risau, W.2
Plate, K.H.3
-
30
-
-
0030726988
-
Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth
-
Lin P, Polverini P, Dewhirst M, Shan S, Rao PS, Peters K. Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. J Clin Invest 1997; 100: 2072-2078.
-
(1997)
J Clin Invest
, vol.100
, pp. 2072-2078
-
-
Lin, P.1
Polverini, P.2
Dewhirst, M.3
Shan, S.4
Rao, P.S.5
Peters, K.6
-
31
-
-
13144254247
-
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2
-
Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. Proc Natl Acad Sci USA 1998; 95: 8829-8834.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8829-8834
-
-
Lin, P.1
Buxton, J.A.2
Acheson, A.3
-
32
-
-
0033168916
-
Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway
-
Siemeister G, Schirner M, Weindel K, et al. Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway. Cancer Res 1999; 59: 3185-3191.
-
(1999)
Cancer Res
, vol.59
, pp. 3185-3191
-
-
Siemeister, G.1
Schirner, M.2
Weindel, K.3
-
33
-
-
0035255001
-
Differential inhibition of tumor angiogenesis by tie2 and vascular endothelial growth factor receptor-2 dominant-negative receptor mutants
-
Stratmann A, Acker T, Burger AM, Amann K, Risau W, Plate KH. Differential inhibition of tumor angiogenesis by tie2 and vascular endothelial growth factor receptor-2 dominant-negative receptor mutants. Int J Cancer 2001; 91: 273-282.
-
(2001)
Int J Cancer
, vol.91
, pp. 273-282
-
-
Stratmann, A.1
Acker, T.2
Burger, A.M.3
Amann, K.4
Risau, W.5
Plate, K.H.6
-
34
-
-
0032714316
-
Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells
-
Hayes AJ, Huang WQ, Mallah J, Yang D, Lippman ME, Li LY. Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells. Microvasc Res 1999; 58: 224-237.
-
(1999)
Microvasc Res
, vol.58
, pp. 224-237
-
-
Hayes, A.J.1
Huang, W.Q.2
Mallah, J.3
Yang, D.4
Lippman, M.E.5
Li, L.Y.6
-
35
-
-
0037966956
-
Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin
-
White RR, Shan S, Rusconi CP, et al. Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin. Proc Natl Acad Sci USA 2003; 100: 5028-5033.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 5028-5033
-
-
White, R.R.1
Shan, S.2
Rusconi, C.P.3
-
36
-
-
7244253411
-
Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1
-
Niu Q, Perruzzi C, Voskas D, Lawler J, Dumont DJ, Benjamin LE. Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1. Cancer Biol Ther 2004; 3: 402-405.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 402-405
-
-
Niu, Q.1
Perruzzi, C.2
Voskas, D.3
Lawler, J.4
Dumont, D.J.5
Benjamin, L.E.6
-
37
-
-
10944262091
-
A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor
-
Tournaire R, Simon M-P, le Noble F, Eichmann A, England P, Pouyssegur J. A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. EMBO Reports 2004; 5: 1-6.
-
(2004)
EMBO Reports
, vol.5
, pp. 1-6
-
-
Tournaire, R.1
Simon, M.2
le Noble, F.3
Eichmann, A.4
England, P.5
Pouyssegur, J.6
-
38
-
-
13444249481
-
Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody
-
Popkov M, Jendreyko N, McGavern DB, Rader C, Barbas CF. Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody. Cancer Research 2005; 65: 972-981.
-
(2005)
Cancer Research
, vol.65
, pp. 972-981
-
-
Popkov, M.1
Jendreyko, N.2
McGavern, D.B.3
Rader, C.4
Barbas, C.F.5
-
39
-
-
61449210829
-
Evaluation of serum vascular endothelial growth factor (VEGF) and microvessel density (MVD) as prognostic indicatorsin carcinoma breast
-
Shivakumar S, Prabhakar BT, Jayashree K, Salimath BP. Evaluation of serum vascular endothelial growth factor (VEGF) and microvessel density (MVD) as prognostic indicatorsin carcinoma breast. J Cancer Res Clin Oncol 2009; 135: 627-636.
-
(2009)
J Cancer Res Clin Oncol
, vol.135
, pp. 627-636
-
-
Shivakumar, S.1
Prabhakar, B.T.2
Jayashree, K.3
Salimath, B.P.4
-
40
-
-
33845382806
-
Nonparametric estimation from incomplete observations
-
Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 456-481.
-
(1958)
J Am Stat Assoc
, vol.53
, pp. 456-481
-
-
Kaplan, E.1
Meier, P.2
-
41
-
-
77950263970
-
Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptor-immunoglobulin fusion protein
-
Zhang D, Li B, Shi J, et al. Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptor-immunoglobulin fusion protein. Cancer Res 2010; 70: 2495-2503.
-
(2010)
Cancer Res
, vol.70
, pp. 2495-2503
-
-
Zhang, D.1
Li, B.2
Shi, J.3
-
42
-
-
0029658585
-
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumour reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma
-
Rosenfeld ME, Wang M, Siegal GP, et al. Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumour reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma. J Mol Med 1996; 74: 455-462.
-
(1996)
J Mol Med
, vol.74
, pp. 455-462
-
-
Rosenfeld, M.E.1
Wang, M.2
Siegal, G.P.3
-
43
-
-
0031755915
-
Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer
-
Rancourt C, Rogers BE, Sosnowski BA, et al. Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer. Clin Cancer Res 1998; 4: 2455-2461.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 2455-2461
-
-
Rancourt, C.1
Rogers, B.E.2
Sosnowski, B.A.3
|