Levetiracetam-induced thrombocytopenia among inpatients: A retrospective study

Epilepsia

Volumn 51, Issue 12, 2010, Pages 2492-2495

  Sahaya, Kinshuk ^a   Goyal, Munish K ^a   Sarwal, Aarti ^b   Singh, Niranjan N ^a  

^a University of Missouri   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Adverse drug reaction; Levetiracetam; Thrombocytopenia

Indexed keywords

ETIRACETAM; THROMBOCYTE CONCENTRATE; VALPROATE SEMISODIUM;

ADD ON THERAPY; ADULT; ADVERSE DRUG REACTION; AGED; ANTICONVULSANT THERAPY; ARTICLE; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG WITHDRAWAL; ERYTHROCYTE CONCENTRATE; FEMALE; GENERALIZED EPILEPSY; HUMAN; LEVETIRACETAM INDUCED THROMBOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SIDE EFFECT; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; BLOOD PLATELETS; DRUG THERAPY, COMBINATION; EPILEPSY, GENERALIZED; FEMALE; HUMANS; MALE; MIDDLE AGED; PIRACETAM; RETROSPECTIVE STUDIES; THROMBOCYTOPENIA;

EID: 78650017520     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2010.02788.x     Document Type: Article

References (10)

1. Elouni B, Ben Salem C, Biour M. (2009) Levetiracetam-induced pancytopenia. Ann Pharmacother 43: 985.
2. French J, Edrich P, Cramer JA. (2001) A systematic review of the safety profile of levetiracetam: a new antiepileptic drug. Epilepsy Res 47: 77-90.
3. Harden C. (2001) Safety profile of levetiracetam. Epilepsia 42 (Suppl 4): 36-39.
4. Hartmann H, Schumacher U, Seeck M. (2002) Verschlechterung einer Immunthrombopenie unter Monotherapie mit Levetiracetam. Akt Neurol 29: 467-468.
5. Kimland E, Hojeberg B, Von Euler M. (2004) Levetiracetam-induced thrombocytopenia. Epilepsia 45: 877-878.
6. Koubeissi MZ, Amina S, Pita I, Bergey GK, Werz MA. (2008) Tolerability and efficacy of oral loading of levetiracetam. Neurology 70: 2166-2170.
7. Krakow K, Walker M, Otoul C, Sander JW. (2001) Long-term continuation of levetiracetam in patients with refractory epilepsy. Neurology 56: 1772-1774.
8. Meschede A, Runge U, Sabolek M. (2008) Thrombocytopenia during levetiracetam therapy. Epilepsy Res 80: 91-92.
9. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. (1981) A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30: 239-245. (Pubitemid 12149145)
10. Nasreddine W, Beydoun A. (2008) Valproate-induced thrombocytopenia: a prospective monotherapy study. Epilepsia 49: 438-445.