Reduced systemic vascular resistance in healthy volunteers with presyncopal symptoms during a nitrate-stimulated tilt-table test

British Journal of Clinical Pharmacology

Volumn 71, Issue 1, 2011, Pages 41-51

  Tahvanainen, Anna ^a   Koskela, Jenni ^a   Leskinen, Miia ^a   Ilveskoski, Erkki ^a   Nordhausen, Klaus ^b   Kähönen, Mika ^a,c   Kööbi, Tiit ^a   Mustonen, Jukka ^a,d   Pörsti, Ilkka ^a,d  

^a Department of Internal Medicine ^*  (Finland)

^b UNIVERSITY OF TAMPERE   (Finland)

^c Heart Center   (Finland)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Impedance cardiography; Nitroglycerine stimulated tilt table test; Presyncope; Pulse wave analysis; Systemic vascular resistance

Indexed keywords

NITRATE; NITRO RESORIBLET; UNCLASSIFIED DRUG;

ADULT; ARTERY RESISTANCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART AFTERLOAD; HEART INDEX; HEART OUTPUT; HEMODYNAMICS; HUMAN; IMPEDANCE CARDIOGRAPHY; MALE; MEAN ARTERIAL PRESSURE; PLETHYSMOGRAPHY; PRESYNCOPE; PRIORITY JOURNAL; PULSE WAVE; SYSTEMIC VASCULAR RESISTANCE; TILT TABLE TEST; VOLUNTEER;

ADULT; CASE-CONTROL STUDIES; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; NITROGLYCERIN; SYNCOPE; TILT-TABLE TEST; VASCULAR RESISTANCE; YOUNG ADULT;

EID: 78650016383     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2010.03794.x     Document Type: Article

References (35)

1. Benditt DG, Ferguson DW, Grubb BP, Kapoor WN, Kugler J, Lerman BB, Maloney JD, Raviele A, Ross B, Sutton R, Wolk MJ, Wood DL. Tilt table testing for assessing syncope. American College of Cardiology. J Am Coll Cardiol 1996; 28: 263-75.
2. Kenny RA, Ingram A, Bayliss J, Sutton R. Head-up tilt: a useful test for investigating unexplained syncope. Lancet 1986; 1: 1352-5.
3. Aerts A, Dendale P. Nitrate stimulated tilt table testing: a review of the literature. Pace 2000; 26: 1528-37.
4. Mason DT, Braunwald E. The effects of nitroglycerin and amyl nitrite on arteriolar and venous tone in the human forearm. Circulation 1965; 32: 755-66.
5. Raviele A, Gasparini G, Di Pede F, Menozzi C, Brignole M, Dinelli M, Alboni P, Piccolo E. Nitroglycerin infusion during upright tilt: a new test for the diagnosis of vasovagal syncope. Am Heart J 1994; 127: 103-11.
6. Kelly RP, Gibbs HH, O'Rourke MF, Daley JE, Mang K, Morgan JJ, Avolio AP. Nitroglycerin has more favourable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery. Eur Heart J 1990; 11: 138-44.
7. Gisolf J, Westerhof BE, Van Dijk N, Wesseling KH, Wieling W, Karemaker JM. Sublingual nitroglycerin used in routine tilt testing provokes a cardiac output-mediated vasovagal response. J Am Coll Cardiol 2004; 44: 588-93.
8. Verheyden B, Gisolf J, Beckers F, Karemaker JM, Wesseling KH, Aubert AE, Wieling W. Impact of age on the vasovagal response provoked by sublingual nitroglycerine in routine tilt testing. Clin Sci (Lond) 2007; 113: 329-37.
9. Mitro P, Hijova E. Myocardial contractility and cardiac filling measured by impedance cardiography in patients with nitroglycerine-induced vasovagal syncope. Pacing Clin Electrophysiol 2006; 29: 1-8.
10. Brignole M, Alboni P, Benditt D, Bergfeldt L, Blanc JJ, Bloch Thomsen PE, Van Dijk JG, Fitzpatrick A, Hohnloser S, Janousek J, Kapoor W, Kenny RA, Kulakowski P, Moya A, Raviele A, Sutton R, Theodorakis G, Wieling W. Guidelines on management (diagnosis and treatment) of syncope. Eur Heart J 2001; 22: 1256-306.
11. Zanzinger J. Role of nitric oxide in the neural control of cardiovascular function. Cardiovasc Res 1999; 43: 639-49.
12. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41.
13. Tahvanainen A, Koskela J, Tikkakoski A, Lahtela J, Leskinen M, Kähönen M, Nieminen T, Kööbi T, Mustonen J, Pörsti I. Analysis of cardiovascular responses to passive head-up tilt using continuous pulse wave analysis and impedance cardiography. Scand J Clin Lab Invest 2009; 69: 128-37.
14. Chen CH, Nevo E, Fetics B, Pak PH, Yin FC, Maughan WL, Kass DA. Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function. Circulation 1997; 95: 1827-36.
15. Kööbi T, Kaukinen S, Turjanmaa VM, Uusitalo AJ. Whole-body impedance cardiography in the measurement of cardiac output. Crit Care Med 1997; 25: 779-85.
16. Kööbi T. Non-invasive cardiac output determination: state of the art. Curr Opin Anaesthesiol 1999; 12: 9-13.
17. Kööbi T, Kähönen M, Iivainen T, Turjanmaa V. Simultaneous non-invasive assessment of arterial stiffness and haemodynamics - a validation study. Clin Physiol Funct Imaging 2003; 23: 31-6.
18. Penaz J. Current photoelectric recording of blood flow through the finger. Cesk Fysiol 1975; 24: 349-52.
19. R Development Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing. R Development Core Team; Vienna2009.
20. Puri ML, Sen PK. Nonparametric Methods in Multivariate Analysis. New York: Wiley & Sons, 1971.
21. Raviele A, Menozzi C, Brignole M, Gasparini G, Alboni P, Musso G, Lolli G, Oddone D, Dinelli M, Mureddu R. Value of head-up tilt testing potentiated with sublingual nitroglycerin to assess the origin of unexplained syncope. Am J Cardiol 1995; 76: 267-72.
22. Koole MA, Aerts A, Praet J, Franken P, Dendale P, Block P. Venous pooling during nitrate-stimulated tilt testing in patients with vasovagal syncope. Europace 2000; 2: 343-5.
23. Novak V, Honos G, Schondorf R. Is the heart 'empty' at syncope? J Auton Nerv Syst 1996; 60: 83-92.
24. De Jong-de Vos van Steenwijk CC, Wieling W, Johannes JM, Harms MP, Kuis W, Wesseling KH. Incidence and hemodynamic characteristics of near-fainting in healthy 6- to 16-year old subjects. J Am Coll Cardiol 1995; 25: 1615-21.
25. Graham LA, Gray JC, Kenny RA. Comparison of provocative tests for unexplained syncope: isoprenaline and glyceryl trinitrate for diagnosing vasovagal syncope. Eur Heart J 2001; 22: 497-503.
26. Fu Q, Witkowski S, Levine BD. Vasoconstrictor reserve and sympathetic neural control of orthostasis. Circulation 2004; 110: 2931-7.
27. Latson TW, Hunter WC, Katoh N, Sagawa K. Effect of nitroglycerin on aortic impedance, diameter, and pulse-wave velocity. Circ Res 1988; 62: 884-90.
28. Millasseau SC, Kelly RP, Ritter JM, Chowienczyk PJ. Determination of age-related increases in large artery stiffness by digital pulse contour analysis. Clin Sci (Lond) 2002; 103: 371-7.
29. Kelly R, Hayward C, Avolio A, O'Rourke M. Noninvasive determination of age-related changes in the human arterial pulse. Circulation 1989; 80: 1652-9.
30. Aerts AJ. Nitrate stimulated tilt table testing: a review of the literature. Pacing Clin Electrophysiol 2003; 26: 1528-37.
31. Del Rosso A, Bartoli P, Bartoletti A, Brandinelli-Geri A, Bonechi F, Maioli M, Mazza F, Michelucci A, Russo L, Salvetti E, Sansoni M, Zipoli A, Fierro A, Ieri A. Shortened head-up tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope. Am Heart J 1998; 135: 564-70.
32. Aerts AJ, Dendale P. Diagnostic value of nitrate stimulated tilt testing without preceding passive tilt in patients with suspected vasovagal syncope and a healthy control group. Pacing Clin Electrophysiol 2005; 28: 29-32.
33. Aerts AJ, Dendale P, Block P, Dassen WR. Reproducibility of nitrate-stimulated tilt testing in patients with suspected vasovagal syncope and a healthy control group. Am Heart J 2005; 150: 251-6.
34. Bogert LW, Van Lieshout JJ. Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger. Exp Physiol 2005; 90: 437-46.
35. Aerts A, Dendale P, Strobel G, Block P. Sublingual nitrates during head-up tilt testing for the diagnosis of vasovagal syncope. Am Heart J 1997; 133: 504-7.