Porcine circovirus type 2 DNA influences cytoskeleton rearrangements in plasmacytoid and monocyte-derived dendritic cells

Immunology

Volumn 132, Issue 1, 2011, Pages 57-65

  Balmelli, Carole ^a   Steiner, Esther ^a,b   Moulin, Hervé ^a,c   Peduto, Nadja ^a,d   Herrmann, Brigitte ^a   Summerfield, Artur ^a   McCullough, Kenneth ^a  

^a INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c Swiss Federal Agricultural Research Station Agroscope Cadenazzo   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Dendritic cells; DNA; Inhibition; Virus

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ACTIN; HEMATOPOIETIC CELL KINASE; PORCINE CIRCOVIRUS TYPE 2 DNA; PROTEIN KINASE LYN; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; VIRUS DNA;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CIRCOVIRUS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOMETRY; CYTOSKELETON; DENDRITIC CELL; ENDOCYTOSIS; GENE SILENCING; IMMUNE DEFICIENCY; MONOCYTE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL;

ACTINS; ANIMALS; CIRCOVIRUS; CYTOSKELETON; DENDRITIC CELLS; DNA, VIRAL; FLOW CYTOMETRY; IMMUNOMODULATION; INTERLEUKIN-6; MICROSCOPY, CONFOCAL; MONOCYTES; PYRIMIDINES; SWINE; TOLL-LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR-ALPHA; VIRUS REPLICATION;

EID: 78650011823     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2010.03339.x     Document Type: Article

References (30)

1. Kaiserlian D, Dubois B. Dendritic cells and viral immunity: friends or foes? Semin Immunol 2001; 13:303-10.
2. Klagge IM, Schneider-Schaulies S. Virus interactions with dendritic cells. J Gen Virol 1999; 80:823-33.
3. Allan GM, McNeilly F, Kennedy S et al. Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. J Vet Diagn Invest 1998; 10:3-10.
4. Ellis J, Hassard LE, Clark EG et al. Isolation of circovirus from lesions of pigs with postweaning multisystemic syndrome. Can Vet J 1998; 39:44-51.
5. Rosell C, Segales J, Ramos-Vara JA et al. Identification of porcine circovirus in tissues of pigs with porcine dermatitis and nephropathy syndrome. Vet Rec 1997; 146:40-3.
6. Segales J, Allan GM, Domingo M. Porcine circovirus diseases. Anim Health Res Rev 2005; 6:119-42.
7. Vincent IE, Carrasco CP, Hermann B, Meehan BM, Allan GM, Summerfield A, McCullough KC. Dendritic cells harbor infectious PCV2 in the absence of apparent cell modulation or replication of the virus. J Virol 2003; 77:13288-300.
8. Vincent IE, Carrasco CP, Guzylack-Piriou L, McCullough KC, Summerfield A. Subset-dependent modulation of dendritic cell activity by circivirus type 2. Immunology 2005; 115:388-98.
9. Vincent IE, Balmelli C, Meehan BM, Allan G, Summerfield A, McCullough KC. Silencing of natural interferon producing cell activation by porcine circovirus type 2 DNA. Immunology 2007; 212:693-9.
10. Krieg AM. A role of Toll in autoimmunity. Nat Immunol 2002; 3:423-4.
11. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21:335-76.
12. Hasslung FC, Berg M, Allan GM, Meehan BM, McNeilly F, Fossum C. Identification of a sequence from the genome of porcine circovirus type 2 with an inhibitory effect on IFN-α production by porcine PBMCs. J Gen Virol 2003; 84:2937-45.
13. Kekarainen T, Montoya M, Dominguez J, Mateu E, Segalés J. Porcine circovirus type 2 (PCV2) viral components immunomodulate recall antigen responses. Vet Immunol Immunopathol 2008; 124:41-9.
14. Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002; 20:709-60.
15. Sanjuan MA, Rao N, Lai K-TA et al. CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion. J Cell Biol 2006; 172:1057-68.
16. Conner SD, Schmid SL. Regulated portal of entry into the cell. Nature 2003; 422:37-44.
17. Carrasco CP, Ridgen RC, Schaffner R et al. Porcine dendritic cells generated in vitro: morphological, phenotypic and functional properties. Immunology 2001; 104:175-84.
18. Diaz DA, Artursson K, L'Haridon R, Perers R, La Bonardiere C, Alm GV. A sensitive immunoassay for porcine interferon-α. Vet Immunol Immunopathol 1992; 30:319-27.
19. McNeilly F, McNair L, Mackie DP et al. Production, characterisation and applications of monoclonal antibodies to porcine circovirus type 2. Arch Virol 2001; 146:909-22.
20. Balmelli C, Alves MP, Steiner E et al. Responsiveness of fibrocytes to Toll like receptor danger signals. Immunobiology 2007; 212:693-9.
21. Guzylack-Piriou L, Balmelli C, McCullough KC, Summerfield A. Type-A CpG oligonucleotides activate exclusively porcine natural interferon-producing cells to secrete inteferon-α, tumor necrosis factor-α and interleukin-12. Immunology 2004; 112:28-37.
22. Nielsen J, Vincent IE, Botner A, Ladekjaer-Mikkelsen A-S, Allan G, Summerfield A, McCullough KC. Association of lymphopenia with the porcine circovirus type 2 induced postweaning multisystemic wasting syndrome. Vet Immunol Immunopathol 2003; 92:97-111.
23. Gilpin DF, McCullough KC, Meehan BM et al. In vitro studies on the infection and replication of porcine circovirus type 2 in cells of the porcine immune system. Vet Immunol Immunopathol 2003; 94:149-61.
24. Hasslung Wikström F, Meehan BM, Berg M et al. Structure-dependent modulation of alpha interferon production by porcine circovirus type 2 oligodeoxyribonucleotide and CpG DNAs in porcine peripheral blood mononuclear cells. J Virol 2007; 81:4919-27.
25. Lenert P. Inhibitory oligonucleotides - therapeutic promise for systemic autoimmune diseases? Clin Exp Immunol 2005; 140:1-10.
26. Stunz LL, Lenert P, Peckham D, Yi AK, Haxhinasto S, Chang M, Krieg AM, Ashman RF. Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells. Eur J Immunol 2002; 32:1212-22.
27. Achuthan A, Elsegood C, Masendycz P, Hamilton JA, Scholz GM. CpG DNA enhances macrophage cell spreading by promoting the src-family kinase-mediated phosphorylation of paxillin. Cell Signal 2006; 18:2252-61.
28. Bolen JB, Brugge JS. Leucocyte protein tyrosine kinases: potential target for drug delivery. Annu Rev Immunol 1997; 15:371-404.
29. Resnati M, Guttinger M, Valcamonica S, Sidenius N, Blasi F, Fazioli F. Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO J 1996; 15:1572-82.
30. Suzuki T, Kono H, Hirose N, Okada M, Yamamoto T, Yamamoto K, Honda Z. Differential involvement of Src family kinases in Fcg receptor-mediated phagocytosis. J Immunol 2000; 165:473-82.