Altered medial temporal activation related to local glutamate levels in subjects with prodromal signs of psychosis

Biological Psychiatry

Volumn 69, Issue 1, 2011, Pages 97-99

  Valli, Isabel ^a   Stone, James ^a,b   Mechelli, Andrea ^a   Bhattacharyya, Sagnik ^a   Raffin, Marie ^a,c   Allen, Paul ^a   Fusar Poli, Paolo ^a,d   Lythgoe, David ^a   O'Gorman, Ruth ^a   Seal, Marc ^e   McGuire, Philip ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c SORBONNE UNIVERSITÉ   (France)

^d UNIVERSITY OF PAVIA   (Italy)

^e MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

Author keywords

Episodic memory; Functional magnetic resonance imaging; Glutamate; Medial temporal cortex; MRS; Psychosis; Schizophrenia

Indexed keywords

GLUTAMIC ACID;

ADULT; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIGH RISK PATIENT; HUMAN; MALE; MEDIAL TEMPORAL CORTEX; MENTAL HEALTH; NEUROTRANSMISSION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POPULATION; PRIORITY JOURNAL; PSYCHOSIS; TISSUE LEVEL; VOLUNTEER;

ADOLESCENT; ADULT; BRAIN MAPPING; GLUTAMIC ACID; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MENTAL RECALL; PSYCHOTIC DISORDERS; TEMPORAL LOBE;

EID: 78649995089     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.08.033     Document Type: Article

References (20)

1. A. Vita, L. De Peri, C. Silenzi, and M. Dieci Brain morphology in first-episode schizophrenia: A meta-analysis of quantitative magnetic resonance imaging studies Schizophr Res 82 2006 75 88
2. P. Boyer, J.L. Phillips, F.L. Rousseau, and S. Ilivitsky Hippocampal abnormalities and memory deficits: New evidence of a strong pathophysiological link in schizophrenia Brain Res Rev 54 2007 92 112
3. J.W. Newcomer, N.B. Farber, V. Jevtovic-Todorovic, G. Selke, A.K. Melson, and T. Hershey Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis Neuropsychopharmacology 20 1999 106 118
4. J. Theberge, R. Bartha, D.J. Drost, R.S. Menon, A. Malla, and J. Takhar Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers Am J Psychiatry 159 2002 1944 1946
5. L.S. Pilowsky, R.A. Bressan, J.M. Stone, K. Erlandsson, R.S. Mulligan, J.H. Krystal, and P.J. Ell First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients Mol Psychiatry 11 2006 118 119
6. X.M. Gao, K. Sakai, R.C. Roberts, R.R. Conley, B. Dean, and C.A. Tamminga Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia Am J Psychiatry 157 2000 1141 1149
7. J.E. Lisman, J.T. Coyle, R.W. Green, D.C. Javitt, F.M. Benes, S. Heckers, and A.A. Grace Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia Trends Neurosci 31 2008 234 242
8. P. Allen, M.L. Seal, I. Valli, P. Fusar-Poli, C. Perlini, and F. Day Altered prefrontal and hippocampal function during verbal encoding and recognition in people with prodromal symptoms of psychosis [published online ahead of print November 23] Schizophr Bull 2009
9. J.M. Stone, F. Day, H. Tsagaraki, I. Valli, M.A. McLean, and D.J. Lythgoe Glutamate dysfunction in people with prodromal symptoms of psychosis: Relationship to gray matter volume Biol Psychiatry 66 2009 533 539
10. C. Pantelis, D. Velakoulis, P.D. McGorry, S.J. Wood, J. Suckling, and L.J. Phillips Neuroanatomical abnormalities before and after onset of psychosis: A cross-sectional and longitudinal MRI comparison Lancet 361 2003 281 288
11. A.R. Yung, L.J. Phillips, P.D. McGorry, C.A. McFarlane, S. Francey, and S. Harrigan Prediction of psychosis A step towards indicated prevention of schizophrenia Br J Psychiatry Suppl 172 1998 14 20
12. S. Coren Measurement of handedness via self-report: The relationship between brief and extended inventories Percept Mot Skills 76 1993 1035 1042
13. S.R. Kay, A. Fiszbein, and L.A. Opler The positive and negative syndrome scale (PANSS) for schizophrenia Schizophr Bull 13 1987 261 276
14. J.W. Olney, and N.B. Farber Glutamate receptor dysfunction and schizophrenia Arch Gen Psychiatry 52 1995 998 1007
15. F.R. Sharp, M. Tomitaka, M. Bernaudin, and S. Tomitaka Psychosis: Pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia? Trends Neurosci 24 2001 330 334
16. M. Day, R. Langston, and R.G. Morris Glutamate-receptor-mediated encoding and retrieval of paired-associate learning Nature 424 2003 205 209
17. C.J. Morgan, and H.V. Curran Acute and chronic effects of ketamine upon human memory: A review Psychopharmacology 188 2006 408 424
18. T.V. Bliss, and G.L. Collingridge A synaptic model of memory: Long-term potentiation in the hippocampus Nature 361 1993 31 39
19. I. Hancu Optimized glutamate detection at 3T J Magn Reson Imaging 30 2009 1155 1162
20. S.T. Patil, L. Zhang, F. Martenyi, S.L. Lowe, K.A. Jackson, and B.V. Andreev Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized phase 2 clinical trial Nat Med 13 2007 1102 1107