-
1
-
-
53949096300
-
Phase I clinical study of three times a day oral administration of TAS-102 in patients with solid tumors
-
Overman, M.J.; Kopetz, S.; Varadhachary, G.; Fukushima, M.; Kuwata, K.; Mita, A.; Wolff, R.A.; Hoff, P.; Xiong, H.; Abbruzzese, J.L. Phase I clinical study of three times a day oral administration of TAS-102 in patients with solid tumors. Cancer Invest., 2008, 26, 794-799.
-
(2008)
Cancer Invest.
, vol.26
, pp. 794-799
-
-
Overman, M.J.1
Kopetz, S.2
Varadhachary, G.3
Fukushima, M.4
Kuwata, K.5
Mita, A.6
Wolff, R.A.7
Hoff, P.8
Xiong, H.9
Abbruzzese, J.L.10
-
2
-
-
0034243820
-
Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells
-
Murakami, Y.; Kazuno, H.; Emura, T.; Tsujimoto, H.; Suzuki, N.; Fukushima, M. Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells. Int. J. Oncol. 2000, 17, 277-283.
-
(2000)
Int. J. Oncol.
, vol.17
, pp. 277-283
-
-
Murakami, Y.1
Kazuno, H.2
Emura, T.3
Tsujimoto, H.4
Suzuki, N.5
Fukushima, M.6
-
3
-
-
16644397018
-
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA
-
Emura, T.; Suzuki, N.; Yamaguchi, M.; Ohshimo, H.; Fukushima,M. A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA. Int. J. Oncol. 2004, 25, 571-578.
-
(2004)
Int. J. Oncol.
, vol.25
, pp. 571-578
-
-
Emura, T.1
Suzuki, N.2
Yamaguchi, M.3
Ohshimo, H.4
Fukushima, M.5
-
4
-
-
0000255832
-
Synthesis, annealing properties, fluorine-19 NMR characterization, and detection limits of a trifluorothymidine-labeled antisense oligodeoxyribonucleotide 21 mer
-
Gmeiner, W.H.; Pon, R.T.; Lown, J.W. Synthesis, annealing properties, fluorine-19 NMR characterization, and detection limits of a trifluorothymidine- labeled antisense oligodeoxyribonucleotide 21 mer. J. Org. Chem., 1991, 56, 3602-3608.
-
(1991)
J. Org. Chem.
, vol.56
, pp. 3602-3608
-
-
Gmeiner, W.H.1
Pon, R.T.2
Lown, J.W.3
-
5
-
-
78650002657
-
Nuclease resistant,pyrimidine modified oligonucleotides that detect and modulate gene expression
-
5,614,617
-
Cook, P.D.; Sanghvi, Y.S. Nuclease resistant,pyrimidine modified oligonucleotides that detect and modulate gene expression. US Patent 5,614,617, 1992
-
(1992)
US Patent
-
-
Cook, P.D.1
Sanghvi, Y.S.2
-
6
-
-
78650009358
-
-
Chem. Abstr. 1992, 117, 111996.
-
(1992)
Chem. Abstr.
, vol.117
, pp. 111996
-
-
-
7
-
-
0035903271
-
Incorporation of 2'-deoxy-5- (trifluoromethyl)uridine and 5-Cyano-2'-deoxyuridine into DNA
-
Markley, J.C.; Chirakul, P.; Sologub, D.; Sigurdsson, S.T. Incorporation of 2'-deoxy-5- (trifluoromethyl)uridine and 5-Cyano-2'-deoxyuridine into DNA. Bioorg. Med. Chem. Lett. 2001, 11, 2453-2455.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 2453-2455
-
-
Markley, J.C.1
Chirakul, P.2
Sologub, D.3
Sigurdsson, S.T.4
-
8
-
-
65349130574
-
Enzymatic synthesis of perfluoroalkylated DNA
-
Holzberger, B.; Marx, A. Enzymatic synthesis of perfluoroalkylated DNA. Bioorgan. Med. Chem. 2009, 17, 3653-3658.
-
(2009)
Bioorgan. Med. Chem.
, vol.17
, pp. 3653-3658
-
-
Holzberger, B.1
Marx, A.2
-
9
-
-
0023677076
-
Functional consequences of the arabinosylcytosine structural lesion in DNA
-
Mikita, T.; Beardsley, G.P. Functional consequences of the arabinosylcytosine structural lesion in DNA. Biochemistry 1988, 27, 4698-4705.
-
(1988)
Biochemistry
, vol.27
, pp. 4698-4705
-
-
Mikita, T.1
Beardsley, G.P.2
-
10
-
-
0026324313
-
Action of 2'2'-difluorodeoxycytidine on DNA synthesis
-
Huang, P.; Chubb, S.; Hertel, L.W.; Grindey, G.B.; Plunkett, W. Action of 2'2'-difluorodeoxycytidine on DNA synthesis. Cancer Res. 1991, 51, 6110-6117.
-
(1991)
Cancer Res.
, vol.51
, pp. 6110-6117
-
-
Huang, P.1
Chubb, S.2
Hertel, L.W.3
Grindey, G.B.4
Plunkett, W.5
-
11
-
-
0027383758
-
The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells
-
Neddermann, P.; Jiricny, J. The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells. J. Biol. Chem. 1993, 268, 21218-21224.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 21218-21224
-
-
Neddermann, P.1
Jiricny, J.2
-
12
-
-
0023370757
-
Exonucleolytic proofreading by calf thymus DNA polymerase delta
-
Kunkel, T.A.; Sabatino, R.D.; Bambara, R.A. Exonucleolytic proofreading by calf thymus DNA polymerase delta. Proc. Natl. Acad. Sci. USA 1987, 84, 4865-4869.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 4865-4869
-
-
Kunkel, T.A.1
Sabatino, R.D.2
Bambara, R.A.3
-
13
-
-
44049101853
-
Mechanisms of base selection by the Escherichia coli mispaired uracil glycosylase
-
Liu, P.; Theruvathu, J.A.; Darwanto, A.; Lao, V.V.; Pascal, T.; Goddard, W. 3rd.; Sowers, L.C. Mechanisms of base selection by the Escherichia coli mispaired uracil glycosylase. J. Biol. Chem. 2008, 283, 8829-8836.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 8829-8836
-
-
Liu, P.1
Theruvathu, J.A.2
Darwanto, A.3
Lao, V.V.4
Pascal, T.5
Goddard III, W.6
Sowers, L.C.7
-
14
-
-
0029156922
-
Thymidylate synthase and drug resistance
-
Peters, G.J.; van, der, Wilt, C.L.; van, Triest, B.; Codacci-Pisanelli, G.; Johnston, P.G.; van, Groeningen, C.J.; Pinedo, H.M. Thymidylate synthase and drug resistance. Eur. J. Cancer 1995, 31A, 1299-1305.
-
(1995)
Eur. J. Cancer
, vol.31 A
, pp. 1299-1305
-
-
Peters, G.J.1
Van Der2
Wilt, C.L.3
Van Triest, B.4
Codacci-Pisanelli, G.5
Johnston, P.G.6
Van Groeningen, C.J.7
Pinedo, H.M.8
-
15
-
-
1442329642
-
An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNA
-
Emura, T.; Nakagawa, F.; Fujioka, A.; Ohshimo, H.; Yokogawa, T.; Okabe, H.; Kitazato, K. An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNA. Int. J. Mol. Med. 2004, 13, 249-255.
-
(2004)
Int. J. Mol. Med.
, vol.13
, pp. 249-255
-
-
Emura, T.1
Nakagawa, F.2
Fujioka, A.3
Ohshimo, H.4
Yokogawa, T.5
Okabe, H.6
Kitazato, K.7
-
16
-
-
0034734383
-
Structure and function in the uracil-DNA glycosylase superfamily
-
Pearl, L.H. Structure and function in the uracil-DNA glycosylase superfamily. Mutat. Res. 2000, 460, 165-181.
-
(2000)
Mutat. Res.
, vol.460
, pp. 165-181
-
-
Pearl, L.H.1
-
17
-
-
0032498302
-
Crystal structure of a G:T/U mismatch-specific DNA glycosylase: Mismatch recognition by complementary-strand interactions
-
Barrett, T.E.; Savva, R.; Panayotou, G.; Barlow, T.; Brown, T.; Jiricny, J.; Pearl, LH. Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Cell 1998, 92, 117-129.
-
(1998)
Cell
, vol.92
, pp. 117-129
-
-
Barrett, T.E.1
Savva, R.2
Panayotou, G.3
Barlow, T.4
Brown, T.5
Jiricny, J.6
Pearl, L.H.7
|