Therapeutic Medical Hypothermia-A Multispecialty Approach

Recent Patents on Cardiovascular Drug Discovery

Volumn 5, Issue 3, 2010, Pages 212-222

  Nanda, Sudip ^a   Patel, Nainesh Ç ^a   Bhatt, Surya P ^b   Mathiesen, Claranne ^a   Castaldo, John ^a   Sharma, Shree G ^c   Longo, Santo ^d  

^a LEHIGH VALLEY HOSPITAL   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF ARKANSAS   (United States)

^d ST LUKE S HOSPITAL   (United States)

Author keywords

Arctic sun; Endovascular cooling device; Hypothermic devices; Therapeutic medical hypothermia

Indexed keywords

ARTICLE; ASYSTOLE; BRAIN DEATH; CARDIOPULMONARY ARREST; ELECTRIC ACTIVITY; HEART ARREST; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPOTHERMIA; NEUROPROTECTION; PATENT; PRIORITY JOURNAL;

CARDIOPULMONARY RESUSCITATION; HEART ARREST; HUMANS; HYPOTHERMIA, INDUCED; TACHYCARDIA, VENTRICULAR; VENTRICULAR FIBRILLATION;

EID: 78649985521     PISSN: 15748901     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489010793351971     Document Type: Article

References (115)

1. de Vreede-Swagemakers JJ, Gorgels AP, Dubois-Arbouw WI, van Ree JW, Daemen MJ, Houben LG, et al. Out-of-hospital cardiac arrest in the 1990's: A population-based study in the Maastricht area on incidence, characteristics and survival. J Am Coll Cardiol 1997; 30(6): 1500-5.
2. American Heart Association. Heart and Stroke Statistical Update. Dallas, Texas: American Heart Associtation 2009.
3. Thorn W, Scholl H, Pfleiderer G, Mueldener B. Metabolic processes in the brain at normal and reduced temperatures and under anoxic and ischaemic conditions. J Neurochem 1958; 2(2-3): 150-65.
4. Bigelow WG, Lindsay WK, Greenwood WF. Hypothermia; its possible role in cardiac surgery: An investigation of factors governing survival in dogs at low body temperatures. Ann Surg 1950; 132(5): 849-66.
5. Rosomoff HL, Holaday DA. Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am J Physiol 1954; 179(1): 85-8.
6. Williams GR Jr, Spencer FC. The clinical use of hypothermia following cardiac arrest. Ann Surg 1958; 148(3): 462-8.
7. Steen PA, Soule EH, Michenfelder JD. Deterimental effect of prolonged hypothermia in cats and monkeys with and without regional cerebral ischemia. Stroke 1979; 10(5): 522-9.
8. Leonov Y, Sterz F, Safar P, Radovsky A. Moderate hypothermia after cardiac arrest of 17 minutes in dogs. Effect on cerebral and cardiac outcome. Stroke 1990; 21(11): 1600-6.
9. Weinrauch V, Safar P, Tisherman S, Kuboyama K, Radovsky A. Beneficial effect of mild hypothermia and detrimental effect of deep hypothermia after cardiac arrest in dogs. Stroke 1992; 23(10): 1454-62.
10. Sterz F, Safar P, Tisherman S, Radovsky A, Kuboyama K, Oku K. Mild hypothermic cardiopulmonary resuscitation improves outcome after prolonged cardiac arrest in dogs. Crit Care Med 1991; 19(3): 379-89.
11. Busto R, Globus MY, Dietrich WD, Martinez E, Valdés I, Ginsberg MD. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 1989; 20(7): 904-10.
12. Coimbra C, Wieloch T. Hypothermia ameliorates neuronal survival when induced 2 hours after ischaemia in the rat. Acta Physiol Scand 1992; 146(4): 543-4.
13. Colbourne F, Li H, Buchan AM. Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats. J Cereb Blood Flow Metab 1999; 19(7): 742-9.
14. Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, et al. Treatment of comatose survivors of out-ofhospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346(8): 557-63.
15. Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346(8): 549-56.
16. Bernard SA, Jones BM, Horne MK. Clinical trial of induced hypothermia in comatose survivors of out-of-hospital cardiac arrest. Ann Emerg Med 1997; 30(2): 146-53.
17. Yanagawa Y, Ishihara S, Norio H, Takino M, Kawakami M, Takasu A, et al. Preliminary clinical outcome study of mild resuscitative hypothermia after out-of-hospital cardiopulmonary arrest. Resuscitation 1998; 39(1-2): 61-6.
18. Zeiner A, Holzer M, Sterz F, Behringer W, Schörkhuber W, Müllner M, et al. Mild resuscitative hypothermia to improve neurological outcome after cardiac arrest. A clinical feasibility trial. Hypothermia after Cardiac Arrest (HACA) Study Group. Stroke 2000; 31(1): 86-94.
19. Nagao K, Hayashi N, Kanmatsuse K, Arima K, Ohtsuki J, Kikushima K, et al. Cardiopulmonary cerebral resuscitation using emergency cardiopulmonary bypass, coronary reperfusion therapy and mild hypothermia in patients with cardiac arrest outside the hospital. J Am Coll Cardiol 2000; 36(3): 776-83.
20. Hachimi-Idrissi S, Corne L, Ebinger G, Michotte Y, Huyghens L. Mild hypothermia induced by a helmet device: A clinical feasibility study. Resuscitation 2001; 51(3): 275-81.
21. Felberg RA, Krieger DW, Chuang R, Persse DE, Burgin WS, Hickenbottom SL, et al. Hypothermia after cardiac arrest: Feasibility and safety of an external cooling protocol. Circulation 2001; 104(15): 1799-804.
22. Al-Senani FM, Graffagnino C, Grotta JC, Saiki R, Wood D, Chung W, et al. A prospective, multicenter pilot study to evaluate the feasibility and safety of using the Cool Gard System and Icy catheter following cardiac arrest. Resuscitation 2004; 62(2): 143-50.
23. Busch M, Soreide E, Lossius HM, Lexow K, Dickstein K. Rapid implementation of therapeutic hypothermia in comatose out-ofhospital cardiac arrest survivors. Acta Anaesthesiol Scand 2006; 50(10): 1277-83.
24. Oddo M, Schaller MD, Feihl F, Ribordy V, Liaudet L. From evidence to clinical practice: Effective implementation of therapeutic hypothermia to improve patient outcome after cardiac arrest. Crit Care Med 2006; 34(7): 1865-73.
25. Sunde K, Pytte M, Jacobsen D, Mangschau A, Jensen LP, Smedsrud C, et al. Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest. Resuscitation 2007; 73(1): 29-39.
26. Kim F, Olsufka M, Longstreth WT Jr, Maynard C, Carlbom D, Deem S, et al. Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4°C normal saline. Circulation 2007; 115(24): 3064-70.
27. Belliard G, Catez E, Charron C, Caille V, Aegerter P, Dubourg O, et al. Efficacy of therapeutic hypothermia after out-of-hospital cardiac arrest due to ventricular fibrillation. Resuscitation 2007; 75(2): 252-9.
28. Arrich J. European Resuscitation Council Hypothermia after Cardiac Arrest Registry Study Group. Clinical application of mild therapeutic hypothermia after cardiac arrest. Crit Care Med 2007; 35(4): 1041-7.
29. Haugk M, Sterz F, Grassberger M, Uray T, Kliegel A, Janata A, et al. Feasibility and efficacy of a new non-invasive surface cooling device in post-resuscitation intensive care medicine. Resuscitation 2007; 75(1): 76-81.
30. Tiainen M, Poutiainen E, Kovala T, Takkunen O, Häppölä O, Roine RO. Cognitive and neurophysiological outcome of cardiac arrest survivors treated with therapeutic hypothermia. Stroke 2007; 38(8): 2303-8.
31. Hoedemaekers CW, Ezzahti M, Gerritsen A, van der Hoeven JG. Comparison of cooling methods to induce and maintain normo- and hypothermia in intensive care unit patients: A prospective intervention study. Crit Care 2007; 11(4): R91.
32. Stammet P, Werer C, Mertens L, Lorang C, Hemmer M. Bispectral index (BIS) helps predicting bad neurological outcome in comatose survivors after cardiac arrest and induced therapeutic hypothermia. Resuscitation 2009; 80(4): 437-42.
33. Doherty DR, Parshuram CS, Gaboury I, Hoskote A, Lacroix J, Tucci M, et al. Canadian critical care trials group. Hypothermia therapy after pediatric cardiac arrest. Circulation 2009; 119(11): 1492-500.
34. Hammer L, Vitrat F, Savary D, Debaty G, Santre C, Durand M, et al. Immediate prehospital hypothermia protocol in comatose survivors of out-of-hospital cardiac arrest. Am J Emerg Med 2009; 27(5): 570-3.
35. Bunch TJ, White RD, Gersh BJ, Shen WK, Hammill SC, Packer DL. Outcomes and in-hospital treatment of out-of-hospital cardiac arrest patients resuscitated from ventricular fibrillation by early defibrillation. Mayo Clin Proc 2004; 79(5): 613-9.
36. Weisfeldt ML, Becker LB. Resuscitation after cardiac arrest: A 3- phase time-sensitive model. JAMA 2002; 288(23): 3035-8.
37. Wik L, Hansen TB, Fylling F, Steen T, Vaagenes P, Auestad BH, et al. Delaying defibrillation to give basic cardiopulmonary resuscitation to patients with out-of-hospital ventricular fibrillation: a randomized trial. JAMA 2003; 289(11): 1389-95.
38. Adrie C, Adib-Conquy M, Laurent I, Monchi M, Vinsonneau C, Fitting C, et al. Successful cardiopulmonary resuscitation after cardiac arrest as a sepsis-like syndrome. Circulation 2002; 106(5): 562-8.
39. Engdahl J, Bång A, Lindqvist J, Herlitz J. Can we define patients with no and those with some chance of survival when found in asystole out of hospital? Am J Cardiol 2000; 86(6): 610-4.
40. Myerburg RJ, Estes D, Zaman L, Luceri RM, Kessler KM, Trohman RG, et al. Outcome of resuscitation from bradyarrhythmic or asystolic prehospital cardiac arrest. J Am Coll Cardiol 1984; 4(6): 1118-22.
41. Neumar RW, Nolan JP, Adrie C, Aibiki M, Berg RA, Böttiger BW, et al. Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation. Circulation 2008; 118(23): 2452-83.
42. Zeiner A, Holzer M, Sterz F, Schörkhuber W, Eisenburger P, Havel C, et al. Hyperthermia after cardiac arrest is associated with an unfavorable neurologic outcome. Arch Intern Med 2001; 161(16): 2007-12.
43. Losert H, Sterz F, Roine RO, Holzer M, Martens P, Cerchiari E, et al. Strict normoglycaemic blood glucose levels in the therapeutic management of patients within 12h after cardiac arrest might not be necessary. Resuscitation 2008; 76(2): 214-20.
44. Aufderheide TP, Lurie KG. Death by hyperventilation: A common and life-threatening problem during cardiopulmonary resuscitation. Crit Care Med 2004; 32(9 Suppl): S345-51.
45. Bell DD, Brindley PG, Forrest D, Al Muslim O, Zygun D. Management following resuscitation from cardiac arrest: Recommendations from the 2003 Rocky Mountain Critical Care Conference. Can J Anaesth 2005; 52(3): 309-22.
46. Bhardwaj A, Ulatowski JA. Hypertonic saline solutions in brain injury. Curr Opin Crit Care 2004; 10(2): 126-31.
47. Koenig MA, Bryan M, Lewin JL 3rd, Mirski MA, Geocadin RG, Stevens RD. Reversal of transtentorial herniation with hypertonic saline. Neurology 2008; 70(13): 1023-9.
48. Marik PE, Varon J. The management of status epilepticus. Chest 2004; 126(2): 582-91.
49. Brain Resuscitation Clinical Trial I Study Group. Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest. N Engl J Med 1986; 314(7): 397-403.
50. Callans DJ. Out-of-hospital cardiac arrest--the solution is shocking. N Engl J Med 2004; 351(7): 632-4.
51. Pusswald G, Fertl E, Faltl M, Auff E. Neurological rehabilitation of severely disabled cardiac arrest survivors. Part II. Life situation of patients and families after treatment. Resuscitation 2000; 47(3): 241-8.
52. Herlitz J, Andersson E, Bång A, Engdahl J, Holmberg M, Lindqvist J, et al. Experiences from treatment of out-of-hospital cardiac arrest during 17 years in Göteborg. Eur Heart J 2000; 21(15): 1251-8.
53. Nichol G, Stiell IG, Hebert P, Wells GA, Vandemheen K, Laupacis A. What is the quality of life for survivors of cardiac arrest? A prospective study. Acad Emerg Med 1999; 6(2): 95-102.
54. Edgren E, Kelsey S, Sutton K, Safar P. Brain Resuscitation Clinical Trial I Study Group. The presenting ECG pattern in survivors of cardiac arrest and its relation to the subsequent long-term survival. Acta Anaesthesiol Scand 1989; 33(4): 265-71.
55. Hoesch RE, Koenig MA, Geocadin RG. Coma after global ischemic brain injury: Pathophysiology and emerging therapies. Crit Care Clin 2008; 24(1): 25-44, vii-viii
56. Vaagenes P, Ginsberg M, Ebmeyer U, Ernster L, Fischer M, Gisvold SE, et al. Cerebral resuscitation from cardiac arrest: Pathophysiologic mechanisms. Crit Care Med 1996; 24(2 Suppl): S57-68.
57. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994; 330(9): 613-22.
58. Globus MY, Ginsberg MD, Busto R. Excitotoxic index--a biochemical marker of selective vulnerability. Neurosci Lett 1991; 127(1): 39-42.
59. Choi DW. Excitotoxic cell death. J Neurobiol 1992; 23(9): 1261-76.
60. Traystman RJ, Kirsch JR, Koehler RC. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appl Physiol 1991; 71(4): 1185-95.
61. Chan PH. Role of oxidants in ischemic brain damage. Stroke 1996; 27(6): 1124-9.
62. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21(1): 2-14.
63. Basu S, Liu X, Nozari A, Rubertsson S, Miclescu A, Wiklund L. Evidence for time-dependent maximum increase of free radical damage and eicosanoid formation in the brain as related to duration of cardiac arrest and cardio-pulmonary resuscitation. Free Radic Res 2003; 37(3): 251-6.
64. Liu XL, Wiklund L, Nozari A, Rubertsson S, Basu S. Differences in cerebral reperfusion and oxidative injury after cardiac arrest in pigs. Acta Anaesthesiol Scand 2003; 47(8): 958-67.
65. Padosch SA, Popp E, Vogel P, Böttiger BW. Altered protein expression levels of Fas/CD95 and Fas ligand in differentially vulnerable brain areas in rats after global cerebral ischemia. Neurosci Lett 2003; 338(3): 247-51.
66. Harukuni I, Bhardwaj A. Mechanisms of brain injury after global cerebral ischemia. Neurol Clin 2006; 24(1): 1-21.
67. Safar P, Behringer W, Böttiger BW, Sterz F. Cerebral resuscitation potentials for cardiac arrest. Crit Care Med 2002; 30(4 Suppl): S140-4.
68. Busch M, Soreide E, Lossius HM, Lexow K, Dickstein K. Rapid implementation of therapeutic hypothermia in comatose out-ofhospital cardiac arrest survivors. Acta Anaesthesiol Scand 2006; 50(10): 1277-83.
69. Holzer M, Müllner M, Sterz F, Robak O, Kliegel A, Losert H, et al. Efficacy and safety of endovascular cooling after cardiac arrest: Cohort study and Bayesian approach. Stroke 2006; 37(7): 1792-7.
70. Rittenberger JC, Guyette FX, Tisherman SA, DeVita MA, Alvarez RJ, Callaway CW. Outcomes of a hospital-wide plan to improve care of comatose survivors of cardiac arrest. Resuscitation 2008; 79(2): 198-204.
71. Nolan JP, Morley PT, Hoek TL, Hickey RW. Advancement life support task force of the international liaison committee on resuscitation. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation. Resuscitation 2003; 57(3): 231-5.
72. Bussière M, Wiebe S. The numbers needed to treat for neurological disorders. Can J Neurol Sci 2005; 32(4): 440-9.
73. Arrich J. European Resuscitation Council Hypothermia after Cardiac Arrest Registry Study Group. Clinical application of mild therapeutic hypothermia after cardiac arrest. Crit Care Med 2007; 35(4): 1041-7.
74. Geocadin RG, Koenig MA, Jia X, Stevens RD, Peberdy MA. Management of brain injury after resuscitation from cardiac arrest. Neurol Clin 2008; 26(2): 487-506, ix
75. Erecinska M, Thoresen M, Silver IA. Effects of hypothermia on energy metabolism in Mammalian central nervous system. Cereb Blood Flow Metab 2003; 23(5): 513-30.
76. Levy DE, Caronna JJ, Singer BH, Lapinski RH, Frydman H, Plum F. Predicting outcome from hypoxic-ischemic coma. JAMA 1985; 253(10): 1420-6.
77. Al Thenayan E, Savard M, Sharpe M, Norton L, Young B. Predictors of poor neurologic outcome after induced mild hypothermia following cardiac arrest. Neurology 2008; 71(19): 1535-7.
78. Young GB. Clinical practice. Neurologic prognosis after cardiac arrest. N Engl J Med 2009; 361(6): 605-11.
79. Zandbergen EG, de Haan RJ, Stoutenbeek CP, Koelman JH, Hijdra A. Systematic review of early prediction of poor outcome in anoxic-ischaemic coma. Lancet 1998; 352(9143): 1808-12.
80. Wijdicks EF, Hijdra A, Young GB, Bassetti CL, Wiebe S. Quality standards subcommittee of the American academy of neurology. Practice parameter: Prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): Report of the quality standards subcommittee of the American Academy of Neurology. Neurology 2006; 67(2): 203-10.
81. Rossetti AO, Logroscino G, Liaudet L, Ruffieux C, Ribordy V, Schaller MD, et al. Status epilepticus: An independent outcome predictor after cerebral anoxia. Neurology 2007; 69(3): 255-60.
82. Wijdicks EF, Parisi JE, Sharbrough FW. Prognostic value of myoclonus status in comatose survivors of cardiac arrest. Ann Neurol 1994; 35(2): 239-43.
83. Rothstein TL. The role of evoked potentials in anoxic-ischemic coma and severe brain trauma. J Clin Neurophysiol 2000; 17(5): 486-97.
84. Zandbergen EG, Koelman JH, de Haan RJ, Hijdra A. PROPACStudy Group. SSEPs and prognosis in postanoxic coma: Only short or also long latency responses? Neurology 2006; 67(4): 583-6.
85. Jørgensen EO, Malchow-Møller A. Natural history of global and critical brain ischaemia. Part I: EEG and neurological signs during the first year after cardiopulmonary resuscitation in patients subsequently regaining consciousness. Resuscitation 1981; 9(2): 133-53.
86. Wijman CA, Mlynash M, Caulfield AF, Hsia AW, Eyngorn I, Bammer R, et al. Prognostic value of brain diffusion-weighted imaging after cardiac arrest. Ann Neurol 2009; 65(4): 394-402.
87. Järnum H, Knutsson L, Rundgren M, Siemund R, Englund E, Friberg H, et al. Diffusion and perfusion MRI of the brain in comatose patients treated with mild hypothermia after cardiac arrest: A prospective observational study. Resuscitation 2009; 80(4): 425-30.
88. Torbey MT, Geocadin R, Bhardwaj A. Brain arrest neurological outcome scale (BrANOS): Predicting mortality and severe disability following cardiac arrest. Resuscitation 2004; 63(1): 55-63.
89. Bassetti C, Bomio F, Mathis J, Hess CW. Early prognosis in coma after cardiac arrest: A prospective clinical, electrophysiological, and biochemical study of 60 patients. J Neurol Neurosurg Psychiatry 1996; 61(6): 610-5.
90. The Quality Standards Subcommittee of the American Academy of Neurology. Practice parameters for determining brain death in adults (summary statement). Neurology 1995; 45(5): 1012-4.
91. Abramson NS, Safar P, Detre KM, Kelsey SF, Monroe J, Reinmuth O, et al. Brain Resuscitation Clinical Trial I Study Group. Neurologic recovery after cardiac arrest: Effect of duration of ischemia. Crit Care Med 1985; 13(11): 930-1.
92. Wijdicks EF. The diagnosis of brain death. N Engl J Med 2001; 344(16): 1215-21.
93. Pell JP, Sirel JM, Marsden AK, Ford I, Walker NL, Cobbe SM. Presentation, management, and outcome of out of hospital cardiopulmonary arrest: Comparison by underlying aetiology. Heart 2003; 89(8): 839-42.
94. Richling N, Herkner H, Holzer M, Riedmueller E, Sterz F, Schreiber W. Thrombolytic therapy vs primary percutaneous intervention after ventricular fibrillation cardiac arrest due to acute ST-segment elevation myocardial infarction and its effect on outcome. Am J Emerg Med 2007; 25(5): 545-50.
95. Knafelj R, Radsel P, Ploj T, Noc M. Primary percutaneous coronary intervention and mild induced hypothermia in comatose survivors of ventricular fibrillation with ST-elevation acute myocardial infarction. Resuscitation 2007; 74(2): 227-34.
96. Hovdenes J, Laake JH, Aaberge L, Haugaa H, Bugge JF. Therapeutic hypothermia after out-of-hospital cardiac arrest: experiences with patients treated with percutaneous coronary intervention and cardiogenic shock. Acta Anaesthesiol Scand 2007; 51(2): 137-42.
97. Wolfrum S, Pierau C, Radke PW, Schunkert H, Kurowski V. Mild therapeutic hypothermia in patients after out-of-hospital cardiac arrest due to acute ST-segment elevation myocardial infarction undergoing immediate percutaneous coronary intervention. Crit Care Med 2008; 36(6): 1780-6.
98. Hosmane VR, Mustafa NG, Reddy VK, DiSabatino A, Kolm P, Hopkins JT, et al. Survival and neurologic recovery in patients with ST-segment elevation myocardial infarction resuscitated from cardiac arrest. J Am Coll Cardiol 2009; 53(5): 409-15.
99. Arrich J, Sterz F, Fleischhackl R, Uray T, Losert H, Kliegel A, et al. Gender modifies the influence of age on outcome after successfully resuscitated cardiac arrest: A retrospective cohort study. Medicine (Baltimore) 2006; 85(5): 288-94.
100. Merchant RM, Soar J, Skrifvars MB, Silfvast T, Edelson DP, Ahmad F, et al. Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest. Crit Care Med 2006; 34(7): 1935-40.
101. Bobrow BJ, Kern KB. Regionalization of postcardiac arrest care. Curr Opin Crit Care 2009; 15(3): 221-7.
102. Merchant RM, Becker LB, Abella BS, Asch DA, Groeneveld PW. Cost-effectiveness of therapeutic hypothermia after cardiac arrest.Cir Cardiovasc Qual Outcomes 2009; 2: doi 10.1161/CIRCOUTCOMES.108.839605.
103. Uray T, Malzer R. Vienna Hypothermia after Cardiac Arrest (HACA) Study Group. Out-of-hospital surface cooling to induce mild hypothermia in human cardiac arrest: A feasibility trial. Resuscitation 2008; 77(3): 331-8.
104. Våga A, Busch M, Karlsen TE, Nilsen OB, Søreide E. A pilot study of key nursing aspects with different cooling methods and devices in the ICU. Resuscitation 2008; 76(1): 25-30.
105. Suffoletto BP, Salcido DD, Menegazzi JJ. National Association of Emergency Medical Services Physicians. Use of prehospitalinduced hypothermia after out-of-hospital cardiac arrest: A survey of the National Association of Emergency Medical Services Physicians. Prehosp Emerg Care 2008; 12(1): 52-6.
106. Bruel C, Parienti JJ, Marie W, Arrot X, Daubin C, Cheyron DD, et al. Mild hypothermia during advanced life support: A preliminary study in out-of-hospital cardiac arrest. Crit Care 2008; 12(1): R31.
107. Green RS, Howes D. Hypothermic modulation of anoxic brain injury in adult survivors of cardiac arrest: A review of the literature and an algorithm for emergency physicians. CJEM 2005; 7(1): 42-7.
108. Marc, E.V., Judy, E.L., Richard, M.Z. Active body cooling with vasodilation to reduce body temperature. US7361186 (2008).
109. Charles, D.L. Method and device for rapidly inducing hypothermia. US7008445 (2006).
110. Eric, W.B. Apparatus and method for preventing brain damage during cardiac arrest, CPR, or severe shock. US20090276018 (2009).
111. Charles, D. L., Steven, M.J., Susan, B., Maria, B., Don, P.N., John, W.C., Helen, M. Method and apparatus for reducing body temperature of a subject. US7621945 (2009).
112. Ben, F.B., Scott, D.W. Devices, systems and methods for rapid endovascular cooling. US20070043409 (2007).
113. Thomas, L.M. Cooling catheter and method with adjunctive therapy capability. US20060058859 (2006).
114. Michael, W.D., Timothy, R.M. Endovascular heat-and gasexchange catheter device and related methods. US6702783 (2004).
115. Dobak, J.D., III, Lasheras, J.C. Inflatable catheter for selective organ heating and cooling and method of using the same. US7651518 (2010).