Cholangiocarcinoma in Italy: A national survey on clinical characteristics, diagnostic modalities and treatment. Results from the " Cholangiocarcinoma" committee of the Italian Association for the Study of Liver disease

Digestive and Liver Disease

Volumn 43, Issue 1, 2011, Pages 60-65

  Alvaro, Domenico ^a   Bragazzi, Maria Consiglia ^a   Benedetti, Antonio ^b   Fabris, Luca ^c   Fava, Giammarco ^b   Invernizzi, Pietro ^d   Marzioni, Marco ^b   Nuzzo, Gennaro ^e   Strazzabosco, Mario ^f   Stroffolini, Tommaso ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^e CATHOLIC UNIVERSITY   (Italy)

^f UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Cholangiocarcinoma; Clinical presentation; Diagnosis; Extra hepatic cholangiocarcinoma; Intra hepatic cholangiocarcinoma; Risk factors; Treatment

Indexed keywords

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; BILE DUCT CARCINOMA; BILIARY TRACT DRAINAGE; BIOPSY; BODY MASS; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CLINICAL FEATURE; FEMALE; GEOGRAPHIC DISTRIBUTION; HUMAN; IMAGING; ITALY; LIVER CIRRHOSIS; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; QUESTIONNAIRE; SEX RATIO; SMOKING HABIT;

ABDOMINAL PAIN; AGED; BILE DUCT NEOPLASMS; BILE DUCTS, EXTRAHEPATIC; BILE DUCTS, INTRAHEPATIC; CHOLANGIOCARCINOMA; CHOLANGIOPANCREATOGRAPHY, ENDOSCOPIC RETROGRADE; CHOLANGIOPANCREATOGRAPHY, MAGNETIC RESONANCE; DATA COLLECTION; DIARRHEA; FATIGUE; FEMALE; HEPATITIS C; HUMANS; ITALY; JAUNDICE; LIVER CIRRHOSIS; MALE; MIDDLE AGED; NAUSEA; TOMOGRAPHY, X-RAY COMPUTED; VOMITING; WEIGHT LOSS;

EID: 78649971678     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2010.05.002     Document Type: Article

References (28)

1. Blechacz B., Gores G.J. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology 2008, 48:308-321.
2. Lazaridis K.N., Gores G.J. Cholangiocarcinoma. Gastroenterology 2005, 128:1655-1667.
3. Khan S.A., Miras A., Pelling M., et al. Cholangiocarcinoma and its management. Gut 2007, 56:1755-1756.
4. Patel T., Singh P. Cholangiocarcinoma: emerging approaches to a challenging cancer. Curr Opin Gastroenterol 2007, 23:317-323.
5. Yachimski P., Pratt D.S. Cholangiocarcinoma: natural history, treatment, and strategies for surveillance in high-risk patients. J Clin Gastroenterol 2008, 42:178-190.
6. Alvaro D., Mancino M.G. New insights on the molecular and cell biology of human cholangiopathies. Mol Aspects Med 2008, 29:50-57.
7. Alvaro D., Mancino M.G., Glaser S., et al. Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 2007, 132:415-431.
8. Patel T. Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology 2001, 33:1353-1357.
9. McGlynn K.A., Tarone R.E., El-Serag H.B. A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States. Cancer Epidemiol Biomarkers Prev 2006, 15:1198-1203.
10. Welzel T.M., McGlynn K.A., Hsing A.W., et al. Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States. J Natl Cancer Inst 2006, 98:873-875.
11. Shaib Y.H., Davila J.A., McGlynn K., et al. Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase?. J Hepatol 2004, 40:472-477.
12. Wood R., Brewster D.H., Fraser L.A., et al. Do increases in mortality from intrahepatic cholangiocarcinoma reflect a genuine increase in risk? Insights from cancer registry data in Scotland. Eur J Cancer 2003, 39:2087-2092.
13. Patel T. Worldwide trends in mortality from biliary tract malignancies. BMC Cancer 2002, 2:10.
14. West J., Wood H., Logan R.F., et al. Trends in the incidence of primary liver and biliary tract cancers in England and Wales 1971-2001. Br J Cancer 2006, 94:1751-1758.
15. Alvaro D, Crocetti E, Ferretti S, et al. Descriptive epidemiology of cholangiocarcinoma in Italy. Digest Liver Dis; in press.
16. Alvaro D. Serum and bile biomarkers for cholangiocarcinoma. Curr Opin Gastroenterol 2009, 25:279-284.
17. Alvaro D., Macarri G., Mancino M.G., et al. Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis. Ann Intern Med 2007, 147:451-459.
18. Alexopoulou A., Soultati A., Dourakis S.P., et al. Cholangiocarcinoma: a 7-year experience at a single center in Greece. World J Gastroenterol 2008, 14:6213-6217.
19. Nakeeb A., Pitt H.A., Sohn T.A., et al. Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg 1996, 224:463-473.
20. Kaczynski J., Hansson G., Wallerstedt S. Incidence, etiologic aspects and clinicopathologic features in intrahepatic cholangiocellular carcinoma-a study of 51 cases from a low-endemicity area. Acta Oncol 1998, 37:77-83.
21. Boberg K.M., Bergquist A., Mitchell S., et al. Cholangiocarcinoma in primary sclerosing cholangitis: risk factors and clinical presentation. Scand J Gastroenterol 2002, 37:1205-1211.
22. El-Serag H.B., Engels E.A., Landgren O., et al. Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: a population-based study of U.S. veterans. Hepatology 2009, 49:116-123.
23. Lee T.Y., Lee S.S., Jung S.W., et al. Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: a case-control study. Am J Gastroenterol 2008, 103:1716-1720.
24. Donato F., Gelatti U., Tagger A., et al. Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case-control study in Italy. Cancer Causes Control 2001, 12:959-964.
25. Kobayashi M., Ikeda K., Saitoh S., et al. Incidence of primary cholangiocellular carcinoma of the liver in Japanese patients with hepatitis C virus-related cirrhosis. Cancer 2000, 88:2471-2477.
26. Gores G.J. Cholangiocarcinoma: current concepts and insights. Hepatology 2003, 37:961-969.
27. Khan S.A., Davidson B.R., Goldin R., et al. Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus document. Gut 2002, 51(Suppl. 6):VI1-VI9.
28. Corvera C.U., Blumgart L.H., Akhurst T., et al. 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer. J Am Coll Surg 2008, 206:57-65.