Universal antibodies against the highly conserved influenza fusion peptide cross-neutralize several subtypes of influenza A virus

Biochemical and Biophysical Research Communications

Volumn 403, Issue 2, 2010, Pages 247-251

  Hashem, Anwar M ^a,b,e   Van Domselaar, Gary ^d   Li, Changgui ^c   Wang, Junzhi ^c   She, Yi Min ^a   Cyr, Terry D ^a   Sui, Jianhua ^f   He, Runtao ^d   Marasco, Wayne A ^f   Li Xuguang, X ^a,e  

^a HEALTH CANADA   (Canada)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^c NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

^d PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^e UNIVERSITY OF OTTAWA   (Canada)

^f DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Cross protection; Fusion peptide; Influenza virus; Universal antibodies

Indexed keywords

HYBRID PROTEIN; INFLUENZA VACCINE; UNCLASSIFIED DRUG; UNI 1 ANTIBODY; VIRUS ANTIBODY; VIRUS HEMAGGLUTININ;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIGEN BINDING; ANTIVIRAL ACTIVITY; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DISEASE COURSE; DRUG BINDING; DRUG TARGETING; INFLUENZA VIRUS A; INFLUENZA VIRUS A H5N1; MAMMAL CELL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; VIROGENESIS; VIRUS STRAIN;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CELL LINE; DOGS; HEMAGGLUTININS, VIRAL; HUMANS; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H5N1 SUBTYPE; VIRUS INTERNALIZATION; VIRUS REPLICATION;

CERCOPITHECINE HERPESVIRUS 1; INFLUENZA A VIRUS; MAMMALIA; ORTHOMYXOVIRIDAE;

EID: 78649958318     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.11.030     Document Type: Article

References (33)

1. Carrat F., Flahault A. Influenza vaccine: the challenge of antigenic drift. Vaccine 2007, 25:6852-6862.
2. Hannoun C., Megas F., Piercy J. Immunogenicity and protective efficacy of influenza vaccination. Virus Res. 2004, 103:133-138.
3. Gerhard W., Mozdzanowska K., Zharikova D. Prospects for universal influenza virus vaccine. Emerg. Infect. Dis. 2006, 12:569-574.
4. Beigel J., Bray M. Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008, 78:91-102.
5. Ludwig S., Planz O., Pleschka S., Wolff T. Influenza-virus-induced signaling cascades: targets for antiviral therapy?. Trends Mol. Med. 2003, 9:46-52.
6. Palese P. Influenza: old and new threats. Nat. Med. 2004, 10:S82-S87.
7. de Jong M.D., Tran T.T., Truong H.K., Vo M.H., Smith G.J., Nguyen V.C., Bach V.C., Phan T.Q., Do Q.H., Guan Y., Peiris J.S., Tran T.H., Farrar J. Oseltamivir resistance during treatment of influenza A (H5N1) infection. N. Engl. J. Med. 2005, 353:2667-2672.
8. Wright P., Neumann G., Kawaoka Y. Orthomyxoviruses, Fields Virology 2006, Lippincott Williams & Wilkins, Philadelphia, PA.
9. Capua I., Alexander D.J. Human health implications of avian influenza viruses and paramyxoviruses. Eur. J. Clin. Microbiol. Infect. Dis. 2004, 23:1-6.
10. Kilbourne E.D. Influenza immunity: new insights from old studies. J. Infect. Dis. 2006, 193:7-8.
11. Stevens J., Blixt O., Tumpey T.M., Taubenberger J.K., Paulson J.C., Wilson I.A. Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science 2006, 312:404-410.
12. Yoshida R., Igarashi M., Ozaki H., Kishida N., Tomabechi D., Kida H., Ito K., Takada A. Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses. PLoS Pathog. 2009, 5:e1000350.
13. Sui J., Hwang W.C., Perez S., Wei G., Aird D., Chen L.M., Santelli E., Stec B., Cadwell G., Ali M., Wan H., Murakami A., Yammanuru A., Han T., Cox N.J., Bankston L.A., Donis R.O., Liddington R.C., Marasco W.A. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat. Struct. Mol. Biol. 2009, 16:265-273.
14. Ekiert D.C., Bhabha G., Elsliger M.A., Friesen R.H., Jongeneelen M., Throsby M., Goudsmit J., Wilson I.A. Antibody recognition of a highly conserved influenza virus epitope. Science 2009, 324:246-251.
15. Chun S., Li C., Van Domselaar G., Wang J., Farnsworth A., Cui X., Rode H., Cyr T.D., He R., Li X. Universal antibodies and their applications to the quantitative determination of virtually all subtypes of the influenza A viral hemagglutinins. Vaccine 2008, 26:6068-6076.
16. Li C., Jaentschke B., Song Y., Wang J., Cyr T.D., Van Domselaar G., He R., Li X. A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide. Nat. Protoc. 2010, 5:14-19.
17. Hashem A.M., Flaman A.S., Farnsworth A., Brown E.G., Van Domselaar G., He R., Li X. Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases. PLoS One 2009, 4:e8350.
18. Lu X., Zhu H. Tube-gel digestion: a novel proteomic approach for high throughput analysis of membrane proteins. Mol. Cell. Proteomics 2005, 4:1948-1958.
19. Gross P.A., Hermogenes A.W., Sacks H.S., Lau J., Levandowski R.A. The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature. Ann. Intern. Med. 1995, 123:518-527.
20. Regoes R.R., Bonhoeffer S. Emergence of drug-resistant influenza virus: population dynamical considerations. Science 2006, 312:389-391.
21. Smith N.M., Bresee J.S., Shay D.K., Uyeki T.M., Cox N.J., Strikas R.A. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep. 2006, 55:1-42.
22. Epstein S.L., Kong W.P., Misplon J.A., Lo C.Y., Tumpey T.M., Xu L., Nabel G.J. Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein. Vaccine 2005, 23:5404-5410.
23. Takada A., Matsushita S., Ninomiya A., Kawaoka Y., Kida H. Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice. Vaccine 2003, 21:3212-3218.
24. Rimmelzwaan G.F., Fouchier R.A., Osterhaus A.D. Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development. Curr. Opin. Biotechnol. 2007, 18:529-536.
25. Epstein S.L. Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature. J. Infect. Dis. 2006, 193:49-53.
26. Sanchez-Fauquier A., Villanueva N., Melero J.A. Isolation of cross-reactive, subtype-specific monoclonal antibodies against influenza virus HA1 and HA2 hemagglutinin subunits. Arch. Virol. 1987, 97:251-265.
27. Tkacova M., Vareckova E., Baker I.C., Love J.M., Ziegler T. Evaluation of monoclonal antibodies for subtyping of currently circulating human type A influenza viruses. J. Clin. Microbiol. 1997, 35:1196-1198.
28. Sanchez-Fauquier A., Guillen M., Martin J., Kendal A.P., Melero J.A. Conservation of epitopes recognized by monoclonal antibodies against the separated subunits of influenza hemagglutinin among type A viruses of the same and different subtypes. Arch. Virol. 1991, 116:285-292.
29. Russ G., Polakova K., Kostolansky F., Styk B., Vancikova M. Monoclonal antibodies to glycopolypeptides HA1 and HA2 of influenza virus haemagglutinin. Acta Virol. 1987, 31:374-386.
30. Wei C.J., Boyington J.C., McTamney P.M., Kong W.P., Pearce M.B., Xu L., Andersen H., Rao S., Tumpey T.M., Yang Z.Y., Nabel G.J. Induction of broadly neutralizing H1N1 influenza antibodies by vaccination. Science 2010, 329:1060-1064.
31. J. Steel, A.C. Lowen, T. Wang, M. Yondola, Q. Gao, K. Haye, A. Garcia-Sastre, P. Palese, Influenza virus vaccine based on the conserved hemagglutinin stalk domain, Mol. Biol. (2010).
32. Wang T.T., Tan G.S., Hai R., Pica N., Ngai L., Ekiert D.C., Wilson I.A., Garcia-Sastre A., Moran T.M., Palese P. Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. Proc. Natl. Acad. Sci. USA 2010.
33. Prabhu N., Prabakaran M., Ho H.T., Velumani S., Qiang J., Goutama M., Kwang J. Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection. J. Virol. 2009, 83:2553-2562.