A C/T mutation in microRNA target sites in BMP5 gene is potentially associated with fatness in pigs

Meat Science

Volumn 87, Issue 3, 2011, Pages 299-303

  Shao, G C ^a   Luo, L F ^a   Jiang, S W ^a   Deng, C Y ^a   Xiong, Y Z ^a   Li, F E ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

Author keywords

Bone morphogenetic protein 5 gene; Fatness; MiRNAs; Pig; Single nucleotide polymorphisms

Indexed keywords

BONE MORPHOGENETIC PROTEIN 5 GENE; FATNESS; MIRNAS; PIG; SINGLE NUCLEOTIDE POLYMORPHISMS;

BONE; CELL CULTURE; NUCLEOTIDES; PROTEINS;

GENE EXPRESSION;

BONE MORPHOGENETIC PROTEIN 5; MICRORNA;

3' UNTRANSLATED REGION; ALGORITHM; ANIMAL; ANIMAL DISEASE; ARTICLE; BINDING SITE; BODY COMPOSITION; CELL CULTURE; CHEMICAL MODEL; FEMALE; FIBROBLAST; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC MARKER; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALE; METABOLISM; MUTATION; OBESITY; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE;

3' UNTRANSLATED REGIONS; ADIPOSITY; ALGORITHMS; ANIMALS; BINDING SITES; BODY COMPOSITION; BONE MORPHOGENETIC PROTEIN 5; CELLS, CULTURED; FEMALE; FIBROBLASTS; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; MALE; MICRORNAS; MODELS, CHEMICAL; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; SUS SCROFA;

PIERIS BRASSICAE; SUIDAE;

EID: 78649943150     PISSN: 03091740     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.meatsci.2010.09.013     Document Type: Article

References (24)

1. Andersson L., Haley C.S., Ellegren H., Knott S.A., Johansson M., Andersson K., et al. Genetic mapping of quantitative trait loci for growth and fatness in pigs. Science 1994, 263(5154):1771-1774.
2. de Koning D.J., Janss L.L., Rattink A.P., van Oers P.A., de Vries B.J., Groenen M.A., et al. Detection of quantitative trait loci for backfat thickness and intramuscular fat content in pigs (Sus scrofa). Genetics 1999, 52:1679-1690.
3. Demeure O., Renard C., Yerle M., Faraut T., Riquet J., Robic A., et al. Rearranged gene order between pig and human in a QTL region on SSC 7. Mammalian Genome 2003, 14:71-80.
4. Hsu P.W.C., Huang H.D., Hsu S.D., Lin L.Z., Tsou A.P., et al. miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes. Nucleic Acids Research 2006, 34:D135-D139.
5. Jeon J.T., Carlborg O., Tornsten A., Giuffra E., Amarger V., Chardon P., et al. A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. Nature Genetics 1999, 21(2):157-158.
6. Kingsley D.M. What do BMP5s do in mammals? Clues from the mouse short ear mutation. Trends in Genetics 1994, 10:16-21.
7. Kingsley D.M., Bland A.E., Grubber J.M., Marker P.C., Russel L.B., Copeland N.G., et al. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF- superfamily. Cell 1992, 71:399-410.
8. Lacombe D., Toutain A., Gorlin R.J., Oley C.A., Battin J. Clinical identification of a human equivalent to the short ear (se) murine phenotype. Annales de Génétique 1994, 37:184-191.
9. Liu B.H. Statistical genomics: linkage, mapping, and QTL analysis 1998, CRC Press, Boca Raton.
10. Liu S., Gao S., Zhang D., Yin J., Xiang Z., Xia Q. MicroRNAs show diverse and dynamic expression patterns in multiple tissues of Bombyx mori. BMC Genomics 2010, 11:85.
11. T Method. Method 2001, 25:402-408.
12. McCarthy J.J., Esser K.A. MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. Journal of Applied Physiology 2007, 102:306-313.
13. Mikic B., Van der Meulen M.C.H., Kingsley D.M., Carter D.R. Long bone geometry and strength in adult BMP-5 deficient mice. Bone 1995, 13:445-454.
14. Nagamine Y., Haley C.S., Sewalem A., Visscher P.M. Quantitative trait loci variation for growth and obesity between and within lines of pigs (Sus scrofa). Genetics 2003, 164:629-635.
15. Rattink A.P., de Koning D.J., Faivre M., Harlizius B., van Arendonk J.A., Groenen M.A. Fine mapping and imprinting analysis for fatness trait QTLs in pigs. Mammalian Genome 2000, 11:656-661.
16. Rohrer G.A., Keele J.W. Identification of quantitative trait loci affecting carcass composition in swine: I. Fat deposition traits. Journal of Animal Science 1998, 76:2247-2254.
17. Rothschild M.F. Identification of quantitative trait loci and interesting candidate gene in the pigs: Progress and prospects. Proceedings of the 6th World Congress on Genetics Applied to Livestock Production 1998, Vol. 26:403-409. Univeristy of New England, Armidale, Australia.
18. 2 resource population. Journal of Animal Science 2003, 81:2938-2949.
19. Shi R., Chiang V.L. Facile means for quantifying microRNA exprission by real-time PCR. Biotechniques 2005, 39:519-525.
20. Sun T., Fu M., Bookout A.L., Kliewer S.A., Mangelsdorf D.J. MicroRNA let-7 regulates 3T3-L1 adipogenesis. Molecular Endocrinology 2009, 23:925-931.
21. Van Laere A.S., Nguyen M., Braunschweig M., Nezer C., Collette C., Moreau L., et al. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 2003, 425(6960):832-836.
22. Wei W.H., de Koning D.J., Penman J.C., Finlayson H.A., Archibald A.L., Haley C.S. QTL modulating ear size and erectness in pigs. Animal Genetics 2007, 38:222-226.
23. Xiong Y.Z., Deng C.Y. Principle and method of swine testing (in Chinese) 1999, Agricultural Publishers of P. R. China, Beijing.
24. Zheng R., Xiong Q., Zuo B., Jiang S.W., Li F.E., Lei M.G., et al. Using RNA interference to identify the different roles of SMAD2 and SMAD3 in NIH/3T3 fibroblast cells. Cell Biochemistry and Function 2008, 5:548-556.