Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells

Acta Pharmacologica Sinica

Volumn 31, Issue 12, 2010, Pages 1593-1603

  Zhu, Yan ^a   Xie, Shu Wu ^a   Zhang, Jian Feng ^b   Zhang, Ting Ting ^c   Zhou, Jie Yun ^a   Cao, Yang ^c   Cao, Lin ^a  

^a SHANGHAI INSTITUTE OF PLANNED PARENTHOOD RESEARCH   (China)

^b FUDAN UNIVERSITY   (China)

^c Yueyang Hospital   (China)

Author keywords

apoptosis; Bcl 2; c Src; estrogen receptor ; gossypol; myometrium; uterine leiomyoma

Indexed keywords

ESTROGEN RECEPTOR ALPHA; GOSSYPOL; PROTEIN BCL 2; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL TYPE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; LEIOMYOMA; MYOMETRIUM; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL; UTERUS MYOMA; WESTERN BLOTTING;

ADULT; APOPTOSIS; CASPASE 3; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGEN RECEPTOR ALPHA; FEMALE; GOSSYPOL; HUMANS; IN SITU NICK-END LABELING; LEIOMYOMA; MYOMETRIUM; PROTO-ONCOGENE PROTEINS C-BCL-2; SRC-FAMILY KINASES; TUMOR CELLS, CULTURED; UTERINE NEOPLASMS;

EID: 78649939950     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.153     Document Type: Article

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