Heroin reduces startle and cortisol response in opioid-maintained heroin-dependent patients

Addiction Biology

Volumn 16, Issue 1, 2011, Pages 145-151

  Walter, Marc ^a   Wiesbeck, Gerhard A ^a   Degen, Bigna ^a   Albrich, Jürgen ^a   Oppel, Monika ^a   Schulz, André ^b   Schächinger, Hartmut ^a,b   Dürsteler Macfarland, Kenneth M ^a,c  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF TRIER   (Germany)

^c UNIVERSITY HOSPITAL OF PSYCHIATRY   (Switzerland)

Author keywords

Cortisol; diacetylmorphine; heroin dependence; methadone; startle reflex; stress

Indexed keywords

DIAMORPHINE; HYDROCORTISONE; METHADONE; OPIATE;

ADULT; AROUSAL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EYELID REFLEX; FEMALE; HEROIN DEPENDENCE; HUMAN; MALE; PRIORITY JOURNAL; SMOKING; STARTLE REFLEX; WHITE NOISE;

EID: 78649939268     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2010.00205.x     Document Type: Article

References (47)

1. Auernhammer CJ, Renner U, Muller OA, Stalla J, Stalla GK, (1993) Loperamide inhibits corticotrophic cell function by a naloxone-insensitive mechanism in the rat in vitro. Neuroendocrinology 57: 1019-1027.
2. Baker TB, Piper ME, McCarthy DE, Majeskie MR, Fiore MC, (2004) Addiction motivation reformulated: an affective processing model of negative reinforcement. Psychol Rev 111: 33-51.
3. Barratt ES, Patton JH, (1983) Impulsivity: cognitive, behavioral, and psychophysiological correlates. In:, Zuckerman M, ed. Biological Bases of Sensation Seeking, Impulsivity, and Anxiety, pp. 77-122. Hillsdale, NJ: Lawrence Erlbaum Associates.
4. Birnbaum SG, Davis M, (1998) Modulation of acoustic startle reflex by infusion of corticotrophin-releasing hormone into the nucleus reticularis pontis caudatus. Brain Res 782: 318-323.
5. Buchanan TW, Brechtel A, Sollers JJ, Lovallo WR, (2001) Exogenous cortisol exerts effects on the startle reflex independent of emotional modulation. Pharmacol Biochem Behav 68: 203-210.
6. Cami J, Gilabert M, San L, Torre DL, (1992) Hypercortisolismus after opioid discontinuation in rapid detoxification of heroin addicts. Br J Addict 87: 1145-1151.
7. Cloninger CR, (1987) A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 44: 573-588.
8. Dickerson SS, Kemeny ME, (2004) Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull 130: 355-391.
9. Dürsteler-MacFarland KM, Störmer R, Seifritz E, Hug I, Müller-Spahn F, Ladewig D, Stohler R, (2000) Opioid-associated effects on oxygen saturation in humans. Addiction 95: 285-287.
10. Dürsteler-MacFarland KM, Stohler R, Moldovanyi A, Rey S, Basdekis R, Gschwend P, Eschmann S, Rehm J, (2006) Complaints of heroin-maintained patients: a survey of symptoms ascribed to diacetylmorphine. Drug Alcohol Depend 81: 231-239.
11. Forman SD, Dougherty GG, Casey BJ, Siegle GJ, Braver TS, Barch DM, Stenger VA, Wick-Hull C, Pisarov LA, Lorensen E, (2004) Opiate addicts lack error-dependent activation of rostral anterior cingulate. Biol Psychiatry 55: 531-537.
12. Gerra G, Leonardi C, Cortese E, Zaimovic A, Dell'Agnello G, Manfredini M, Somaini L, Petracca F, Caretti V, Baroni C, Donnini C, (2008) Adrenocorticotropic hormone and cortisol plasma levels directly correlate with childhood neglect and depression measures in addicted patients. Addict Biol 13: 95-104.
13. Grillon C, Duncko R, Covington M, Kopperman L, Kling M, (2007) Acute stress potentiates anxiety in humans. Biol Psychiatry 62: 1183-1186.
14. Harris AC, Gewirtz JC, (2004) Elevated startle during withdrawal from acute morphin: a model of opiate withdrawal and anxiety. Psychopharmacology 171: 140-147.
15. Kakko J, Von Wachenfeldt J, Svanborg KD, Lidström J, Barr CS, Heilig M, (2008) Mood and neuroendocrine response to a chemical stressor, metyrapone, in buphrenorphine-maintained heroin dependence. Biol Psychiatry 63: 172-177.
16. Kling MA, Carson RE, Borg L, Zametkin A, Matochik JA, Schluger J, Herscovitch P, Rice KC, Ho A, Eckelman WC, Kreek MJ, (2000) Opioid receptor imaging with positron emission tomography and [(18)F]cyclofoxy in long-term, methadone-treated former heroin addicts. J Pharmacol Exp Ther 295: 1070-1076.
17. Klous MG, Van den Brink W, Van Ree JM, Beijnen JH, (2005) Development of pharmaceutical heroin preparations for medical co-prescription to opioid dependent patients. Drug Alcohol Depend 80: 283-295.
18. Koob GF, Le Moal M, (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24: 97-129.
19. Koob GF, Le Moal M, (2006) Neurobiology of Addiction. London: Elsevier.
20. Kreek MJ, (2000) Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine. Ann N Y Acad Sci 909: 186-216.
21. Kreek MJ, LaForge KS, Butelman E, (2002) Pharmacotherapy of addictions. Nat Rev Drug Discov 1: 710-726.
22. Kudielka BM, Kirschbaum C, (2005) Sex differences in HPA axis responses to stress: a review. Biol Psychol 69: 113-132.
23. Lang PJ, Bradley MM, Cuthbert BN, (1990) Emotion, attention, and the startle reflex. Psychol Rev 97: 377-395.
24. Le Moal M, Koob GF, (2007) Drug addiction: pathways to the disease and pathophysiological perspectives. Eur Neuropsychopharmacol 17: 377-393.
25. Leshner AI, (1997) Addiction is a brain disease, and it matters. Science 278: 45-47.
26. McKay JR, Alterman AI, Mulvaney FD, Koppenhaver JM, (1999) Predicting proximal factors in cocaine relapse and near miss episodes: clinical and theoretical implications. Drug Alcohol Depend 56: 67-78.
27. Miller MW, Gronfier C, (2006) Diurnal variation of the startle reflex in relation to HPA-axis activity in humans. Psychophysiology 43: 297-301.
28. Miranda R, Meyerson LA, Myers RR, Lovallo WR, (2003) Altered affective modulation of the startle reflex in alcoholics with antisocial personality disorder. Alcohol Clin Exp Res 27: 1901-1911.
29. Perneger TV, Giner F, Del Rio M, Mino A, (1998) Randomised trail of heroin maintenance programme for addicts who fail in conventional drug treatments. BMJ 317: 13-18.
30. Polydorou S, Kleber HD, (2008) Detoxification of opioids. In:, Galanter M, Kleber HD, eds. The American Psychiatric Publishing Textbook of Substance Abuse Treatment, pp. 265-287. Washington, DC: American Psychiatric Publishing.
31. Rassnick S, Koob GF, Geyer MA, (1992) Responding to acoustic startle during chronic ethanol intoxication and withdrawal. Psychopharmacology 106: 351-358.
32. Roemer S, Nees F, Richter S, Blumenthal TD, Schächinger H, (2009) Endogenous cortisol suppression with metyrapone enhances acoustic startle in healthy subjects. Horm Behav 55: 314-318.
33. Saladin ME, Drobes DJ, Coffey SF, Libet JM, (2002) The human startle reflex and alcohol cure reactivity: effects of early versus late abstinence. Psychol Addict Behav 16: 98-105.
34. Schluger JH, Borg L, Ho A, Kreek MJ, (2001) Altered HPA axis responsivity to metyrapone testing in methadone maintained former heroin addicts with ongoing cocaine addiction. Neuropsychopharmacology 24: 568-575.
35. Schluger JH, Bart G, Green M, Ho A, Kreek MJ, (2003) Corticotropin- releasing factor testing reveals a dose dependent difference in methadone maintained vs control subjects. Neuropsychopharmacology 28: 985-994.
36. Shaman Y, Stewart J, (1994) Exposure to mild stress enhances the reinforcing efficacy of intravenous heroin self-administration in rats. Psychopharmacology 114: 523-527.
37. Stine SM, Grillon CG, Morgan III CA, Koston TR, Charney DS, Krystal JH, (2001) Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine. Psychopharmacology 154: 274-281.
38. Stoermer R, Drewe J, Dürsteler-MacFarland KM, Ladewig D, Hock C, Müller-Spahn F, Stohler R, Mager R, (2003) Safety of injectable opioid treatment in addiction: a controlled clinical trial. Biol Psychiatry 54: 854-861.
39. Stohler R, Dürsteler KM, Störmer R, Seifritz E, Hug I, Sattler-Mayr J, Müller-Spahn F, Ladewig D, Hock C, (1999) Rapid cortical hemoglobin deoxygenation after heroin and methadone injection in humans: a preliminary report. Drug Alcohol Depend 57: 23-28.
40. Strain EC, Stitzer ML, (2006) The Treatment of Opioid Dependence. Baltimore, MD: John Hopkins University Press.
41. Swann AC, Bjork JM, Moeller G, Dougherty DM, (2002) Two models of impulsivity: relationship to personality traits and psychopathology. Biol Psychiatry 51: 988-994.
42. Sweitzer MM, Allen PA, Kaut KP, (2008) Relation of individual differences in impulsivity to nonclinical emotional decision making. J Int Neuropsychol Soc 14: 878-882.
43. Takai N, Yamaguchi M, Aragaki T, Eto K, Uchihashi K, Nishikawa Y, (2004) Effect of psychological stress on the salivary cortisol and amylase levels in healthy young adults. Arch Oral Biol 49: 963-968.
44. Turpin G, Schaefer F, Boucsein W, (1999) Effects of stimulus intensity, risetime, and duration on autonomic and behavioral responding: implications for the differentiation of orienting, startle, and defense responses. Psychophysiology 36: 453-463.
45. Uchtenhagen A, Dobler-Mikola A, Gutzwiler F, (1996) Medical prescription of narcotics: background and intermediate results of a Swiss national project. Eur Addict Res 2: 201-207.
46. Walter M, Gerhard U, Gerlach M, Weijers H-G, Boening J, Wiesbeck GA, (2006) Cortisol concentrations, stress-coping styles after withdrawal, and long-term abstinence in alcohol dependence. Addict Biol 11: 157-162.
47. Walter M, Wiesbeck GA, Bloch N, Aeschbach S, Olbrich HM, Seifritz E, Dürsteler-MacFarland KM, (2008) Psychobiological responses to drug cues before and after methadone intake in heroin-dependent patients: a pilot study. Eur Neuropsychopharmacol 18: 390-393.