Methylenetetrahydrofolate reductase C677T gene mutation as risk factor for sudden sensorineural hearing loss: Association with plasma homocysteine, folate and cholesterol concentrations

Journal of Laryngology and Otology

Volumn 124, Issue 12, 2010, Pages 1268-1273

  Lee, E J ^a   Cho, Y J ^a   Yoon, Y J ^a  

^a Chonbuk National University Medical School   (South Korea)

Author keywords

Cholesterol; Folate; Homocysteine; MTHFR; Sudden Hearing Loss

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CHOLESTEROL; FOLIC ACID; HOMOCYSTEINE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD EXAMINATION; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLIC ACID BLOOD LEVEL; GENE MUTATION; GENOTYPE; HUMAN; MALE; PERCEPTION DEAFNESS; RISK FACTOR;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CHILD; CHOLESTEROL; COCHLEA; FEMALE; FOLIC ACID; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEARING LOSS, SENSORINEURAL; HEARING LOSS, SUDDEN; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTATION; RISK FACTORS; YOUNG ADULT;

EID: 78649921120     PISSN: 00222151     EISSN: 17485460     Source Type: Journal    
DOI: 10.1017/S002221511000099X     Document Type: Article

References (21)

1. Lazarini PR, Cameargo AC. Idiopathic sudden sensorineural hearing loss: Etiopathogenic aspects. Braz J Otorhinolaryngol 2006;72:554-61
2. Stokroos RJ, Albers FW, Schirm J. The etiology of idiopathic sudden sensorineural hearing loss. Experimental herpes simplex virus infection of the inner ear. Am J Otolaryngol 1998;19:447-52
3. Berrocal JR, Ramirez-Camacho R. Sudden sensorineural hearing loss: Supporting the immunologic theory. Ann Otol Rhinol Laryngol 2002;111:989-97
4. Boulassel MR, Deggouj N, Tomasi N, Gersdorff M. Inner ear autoantibodies and their targets in patients with autoimmune inner ear diseases. Acta Otolaryngol 2001;121: 28-34
5. Cadoni G, Agostino S, Manna R, De Santis A, Fetoni AR, Vulpiani P et al. Clinical associations of serum antiendothelial cell antibodies in patients with sudden sensorineural hearing loss. Laryngoscope 2003;113:797-801
6. Schweinfurth JM, Cacace AT. Cochlear ischemia induced by circulating iron particles under magnetic control: An animal model for sudden hearing loss. Am J Otolaryngol 2000;21:636-40
7. Guo Y, Zhang C, Du X, Nair U, Yoo TJ. Morphological and functional alterations of the cochlea in apolipoprotein E gene deficient mice. Hear Res 2005;208:54-67
8. Schuknecht HF, Kimura RS, Naufal PM. The pathology of sudden deafness. Acta Otolaryngol 1973;76:75-97
9. Nagahara K, Fisch U, Yagi N. Perilymph oxygenation in sudden and progressive sensorineural hearing loss. Acta Otolaryngol 1983;96:57-68
10. Suckfull M. Fibrinogen and LDL apheresis in treatment of sudden hearing loss: A randomized multicentre trial. Lancet 2002;360:1811-17
11. Nakamura M, Whitlock G, Aoki N, Nakashima T, Hoshino T, Yokoyama T et al. Japanese and western diet and risk of idiopathic sudden deafness: A case-control study using pooled controls. Int J Epidemiol 2001;30:608-15
12. Menachem G, Gideon F, Ron E, Nira KM, Neta G, Iman AA et al. Impact of methionine synthase gene and methylenetetrahydrofolate reductase gene polymorphisms on the risk of sudden sensorineural hearing loss. Audiol Neurotol 2006;11:287-93
13. Van Guldenet C, Stehouwer CD. Hyperhomocysteinaemia and vascular disease - a role for DNA hypomethylation? Lancet 2003;361:1668-9
14. Friedman G, Goldschmidt N, Friedlander Y, Ben-Yehuda A, Selhub J, Babaey S et al. A common mutation A1298C in human methylenetetrahydrofolate reductase gene: Association with plasma total homocysteine and folate concentrations. J Nutr 1999;129:1656-61
15. Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M et al. Human methionine synthase: CDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Hum Mol Genet 1996;5:1867-74
16. Lievers KJ, Boers GH, Verhoef P, den Heijer M, Kluijtmans LA, van der Put NM et al. A second common variant in the MTHFR gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk. J Mol Med 2001;79:522-8
17. Capaccio P, Ottaviani F, Cuccarini V, Ambrosetti U, Fagnani E, Bottero A et al. Methylenetetrahydrofolate reductase gene mutations as risk factors for sudden hearing loss. Am J Otolaryngol 2005;26:383-7
18. Yamasoba T, Kikuchi S, Higo R, O'uchi T, Tokumaru A. Sudden sensorineural hearing loss associated with slow blood flow of the vertebrobasilar system. Ann Otol Rhinol Laryngol 1993;102:873-7
19. Capaccio P, Ottaviani F, Cuccarini V, Bottero A, Schindler A, Cesana BM et al. Genetic and acquired prothrombotic risk factors and sudden hearing loss. Laryngoscope 2007; 117:547-51
20. Mattson MP, Kruman II, Duan W. Folic acid and homocysteine in age-related disease. Ageing Res Rev 2002;1:95-111
21. Hirano K, Ikeda K, Kawase T, Oshima T, Kekehata S, Takahashi S et al. Prognosis of sudden deafness with special reference to risk factors of microvascular pathology. Auris Nasus Larynx 1999;26:111-15