Metabolization of nifurtimox and benznidazole in cellular fractions of rat mammary tissue

Human and Experimental Toxicology

Volumn 29, Issue 10, 2010, Pages 813-822

  Bartel, Laura Cecilia ^a   Montalto De Mecca, María ^a   Rodríguez De Castro, Carmen ^a   Bietto, Florencia Matilde ^a   Castro, José Alberto ^a  

^a Centro de Investigaciones Toxicologicos   (Argentina)

Author keywords

American trypanosomiasis; benznidazole; Chagas' disease; mammary tissue; nifurtimox; nitroreductase activity

Indexed keywords

ALLOPURINOL; BENZNIDAZOLE; CARBON MONOXIDE; CARBONYL DERIVATIVE; DIPHENYLIODONIUM SALT; LIPID HYDROPEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NIFURTIMOX; PURINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL DERIVATIVE; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST; CELL FRACTIONATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CYTOSOL; DRUG ACTIVATION; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG TISSUE LEVEL; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION KINETICS; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; TISSUE HOMOGENATE; TOXICOKINETICS; TRANSMISSION ELECTRON MICROSCOPY;

ALLOPURINOL; ANIMALS; CELL FRACTIONATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; LIPID PEROXIDATION; MAMMARY GLANDS, ANIMAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSOMES; NIFURTIMOX; NITROIMIDAZOLES; NITROREDUCTASES; PROTEIN CARBONYLATION; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS; TRYPANOCIDAL AGENTS;

RATTUS;

EID: 78649914958     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110361756     Document Type: Article

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