Effect of splitting simvastatin tablets for control of low-density lipoprotein cholesterol

American Journal of Cardiology

Volumn 95, Issue 12, 2005, Pages 1481-1483

  Parra, David ^a   Beckey, Nick P ^b   Raval, Harsha S ^b   Schnacky, Kimberly R ^b   Calabrese, Vincent ^b   Coakley, Roy W ^b   Goodhope, Robert C ^b  

^a Section of Cardiology (119A)   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN;

ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ECONOMICS; HEALTH CARE COST; HEALTH CARE SYSTEM; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MEASUREMENT; PATIENT COMPLIANCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

ADMINISTRATION, ORAL; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL, LDL; COST-BENEFIT ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FOLLOW-UP STUDIES; HUMANS; HYPERCHOLESTEROLEMIA; PATIENT COMPLIANCE; RETROSPECTIVE STUDIES; SAFETY; SIMVASTATIN; TABLETS; TREATMENT OUTCOME;

EID: 20444480876     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2005.02.019     Document Type: Article

References (15)

1. J.P. Rindone, R. Achacoso, R. Bledsoe Effect of lovastatin administered every other day on serum low-density lipoprotein cholesterol >160 mg/dl Am J Cardiol 76 1995 312 313
2. V.C. Dennis, M.L. Britton, S.M. Sirmans, N.A. Letassy, D.A. Freeman The use of alternate-day lovastatin in hypercholesterolemic men Ann Pharmacother 31 1997 708 712
3. J.P. Rindone, D. Hiller, G. Arriola A comparison of fluvastatin 40 mg every other day versus 20 mg every day in patients with hypercholesterolemia Pharmacotherapy 18 1998 836 839
4. K. Flynn, E. Alligood, E. Adams Tablet splitting VA TAP Short Rep 3 2000 1 7
5. J.M. Rosenberg, J.P. Nathan, F. Plakogiannis Weight variability of pharmacist-dispensed split tablets J Am Pharm Assoc 42 2002 200 205
6. J. Teng, C.K. Song, R.L. Willliams, J.E. Polli Lack of medication dose uniformity in commonly split tablets J Am Pharm Assoc 42 2002 195 199
7. M. Stimpel, B. Kuffer, H. Groth, W. Vetter Breaking tablets in half Lancet 1 1984 1299
8. P. Gupta, K. Gupta Broken tablets does the sum of the parts equal the whole? Am J Hosp Pharm 45 1988 1498
9. M. Sedrati, P. Arnaud, J.E. Fontan, F. Brion Splitting tablets in half Am J Hosp Pharm 51 1994 548 552
10. J.T. McDevitt, A.H. Gurst, Y. Chen Accuracy of tablet splitting Pharmacotherapy 18 1998 193 197
11. B.T. Peek, A. Al-Achi, S.J. Coombs Accuracy of tablet splitting by elderly patients. Research letter JAMA 288 2002 451 452
12. C.A. Jackevicius, M. Mamdani, J.V. Tu Adherence with statin therapy in elderly patients with and without acute coronary syndromes JAMA 288 2002 462 467
13. J.S. Benner, R.J. Glynn, H. Mogun, P.J. Neumann, M.C. Weinstein, J. Avorn Long-term persistence in use of statin therapy in elderly patients JAMA 288 2002 455 461
14. M.C. Duncan, S.S. Castle, D.S. Streetman Effect of tablet splitting on serum cholesterol concentrations Ann Pharmacother 36 2002 205 209
15. M. Gee, N. Hasson Effects of tablet-splitting program in patients taking HMG-CoA reduction inhibitors analysis of clinical effects, patient satisfaction, compliance and cost avoidance J Manag Care Pharm 6 2002 453 458