Combined topical fluconazole and corticosteroid treatment for experimental Candida albicans keratomycosis

Investigative Ophthalmology and Visual Science

Volumn 44, Issue 6, 2003, Pages 2634-2643

  Schreiber, Wolfram ^a   Olbrisch, Antje ^a   Vorwerk, Christian K ^a   König, Wolfgang ^a   Behrens Baumann, Wolfgang ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; FLUCONAZOLE; PREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CONCENTRATION RESPONSE; CONJUNCTIVITIS; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; CORNEA PERFORATION; CORNEA ULCER; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HYPOPYON; KERATOMYCOSIS; LOW DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; TREATMENT OUTCOME;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDIASIS; CONJUNCTIVITIS; CORNEA; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; EYE INFECTIONS, FUNGAL; FEMALE; FLUCONAZOLE; GLUCOCORTICOIDS; KERATITIS; NEOVASCULARIZATION, PATHOLOGIC; PREDNISOLONE; RABBITS; TIME FACTORS;

EID: 0038485756     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.02-1135     Document Type: Article

References (31)

1. Rosa RH, Miller D, Alfonso EC. The changing spectrum of fungal keratitis in south Florida. Ophthalmology. 1994;101:1005-1013.
2. Ishibashi Y. Keratomycosis in Japan reported from 1976 to 1980 [in Japanese]. Nippon Ganka Gakkai Zasshi. 1982;86:651-656.
3. Gugnani HC, Talwar RS, Njoku-Obi AN, Kodilinye HC. Mycotic keratitis in Nigeria: a study of 21 cases. Br J Ophthalmol. 1976; 60:607-613.
4. Poria VC, Bharad VR, Dongre DS, Kulkarni MV. Study of mycotic keratitis. Indian J Ophthalmol. 1985;33:229-231.
5. Khairallah SH, Byrne KA, Tabbara KF. Fungal keratitis in Saudi Arabia. Doc Ophthalmol. 1992;79:269-276.
6. Sundaram BM, Badrindath S, Subramanian S. Studies on mycotic keratitis. Mycoses. 1989;32:568-572.
7. Wilson LA, Ahearn DG. Association of fungi with extended-wear soft contact lenses. Am J Ophthalmol. 1986;101:434-436.
8. Chern KC, Meisler DM, Wilhelmus KR, Jones DB, Stern GA, Lowder CY. Corneal anesthetic abuse and Candida keratitis. Ophthalmology. 1996;103:37-40.
9. Ishibashi Y, Kaufman HE, Kawaga ST. Differences in development of keratomycosis after Candida inoculation in the central and peripheral cornea. J Med Vet Mycol. 1986;24:437-444.
10. Kaufman HE, Wood RM. Mycotic keratitis. Am J Ophthalmol. 1965;59:993-997.
11. Behrens-Baumann W. Results of keratoplasty à chaud [in German]. Klin Monatsbl Augenheilkd. 1984;185:25-27.
12. Walsh TJ. Recent advances in the treatment of systemic fungal infections. Methods Find Exp Clin Pharmacol. 1987;9:769-778.
13. Montero-Gei F. Fluconazole: pharmacokinetics and indications. Arch Med Res. 1993;24:377-385.
14. Kowalsky SF, Dixon DM. Fluconazole: a new antifungal agent. Clin Pharm. 1991;10:179-194.
15. Panda A, Sharma N, Angra SK. Topical fluconazole therapy of Candida keratitis. Cornea. 1996;15:373-375.
16. Urbak SF, Degn T. Fluconazole in the management of fungal ocular infections. Ophthalmologica. 1994;208:147-156.
17. Behrens-Baumann W, Klinge B, Rüchel R. Topical fluconazole for experimental Candida keratitis in rabbits. Br J Ophthalmol. 1990; 74:40-42.
18. Ishibashi Y. The difference of the effects on experimental keratomycosis due to the length of medicational period of corticosteroids [in Japanese]. Nippon Ganka Gakkai Zasshi. 1982;86: 1438-1442.
19. Maylath FR, Leopold IH. Study of experimental intraocular infections. Am J Ophthalmol. 1955;40:86-101.
20. Behrens-Baumann W, Küster, M. Effect of corticosteroids in antimycotic therapy of Candida keratitis [in German]. Klin Monatsbl Augenheilkd. 1987;191:222-225.
21. O'Day DM, Ray WA, Head WS, Robinson RD, Williams TE. Influence of corticosteroid on experimentally induced keratomycosis. Arch Ophthalmol. 1991;109:1601-1604.
22. Stern GA, Buttross M. Use of corticosteroids in combination with antimicrobial drugs in the treatment of infectious corneal disease. Ophthalmology. 1991;98:847-853.
23. Garber JM. Steroids' effects on the infectious corneal ulcer. J Am Optom Assoc. 1980;51:477-483.
24. Smolin G, Okumoto M. Potentiation of Candida albicans keratitis by antilymphocyte serum and corticosteroids. Am J Ophthalmol. 1969;68:675-682.
25. Louria DB, Fallon N, Browne HG. The influence of cortisone on experimental fungus infections in mice. J Clin Invest. 1960;39: 1435-1499.
26. O' Day DM, Ray WA, Head WS, Robinson RD. Efficacy of antifungal agents in the cornea. IV. Amphotericin B methyl ester. Invest Ophthalmol Vis Sci. 1984;25:851-854.
27. Behrens-Baumann W, Uter W, Vogel M, Ansorg R. Animal experiment model of keratomycosis [in German]. Klin Monatsbl Augenheilkd. 1987;190:496-500.
28. Behrens-Baumann W, Begall T. Reproducible model of a bacterial conjunctivitis. Ophthalmologica. 1993;206:69-75.
29. Fromtling RA. Overview of medically important antifugal azole derivatives. Clin Microbiol Rev. 1988;1:187-217.
30. Robinson MR, Baffi J, Yuan P, et al. Safety and pharmacokinetics of intravitreal 2-methoxyestradiol implants in normal rabbit and pharmacodynamics in a rat model of choroidal neovascularization. Exp Eye Res. 2002;74:309-317.
31. Behrens-Baumann W. Mycosis of the eye and its adnexa. Basel, Switzerland: Karger; 1999:162-171.