Genistein improves neuropathology and corrects behaviour in a mouse model of neurodegenerative metabolic disease

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Malinowska, Marcelina ^a,b   Wilkinson, Fiona L ^a   Langford Smith, Kia J ^a   Langford Smith, Alex ^a   Brown, Jillian R ^c   Crawford, Brett E ^c   Vanier, Marie T ^d   Grynkiewicz, Grzegorz ^e   Wynn, Rob F ^f   Ed Wraith, J ^g   Wegrzyn, Grzegorz ^b   Bigger, Brian W ^a,f  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF GDA SK   (Poland)

^c Zacharon Pharmaceuticals Inc   (United States)

^d UNIVERSITÉ DE LYON   (France)

^e INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONE; GANGLIOSIDE GM2; GANGLIOSIDE GM3; GENISTEIN; HEPARAN SULFATE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; SYNAPTOBREVIN 2; PROTEIN KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; FEMALE; HIPPOCAMPUS; LOCOMOTION; LYSOSOME STORAGE DISEASE; MALE; MOTOR COORDINATION; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; SANFILIPPO SYNDROME; SYNAPSE VESICLE; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; C57BL MOUSE; CHEMISTRY; DEGENERATIVE DISEASE; DISEASE MODEL; GENE EXPRESSION REGULATION; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; LIVER; LYSOSOME; METABOLISM; METHODOLOGY; NERVE CELL;

MUS;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENISTEIN; HEPARITIN SULFATE; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; LIVER; LYSOSOMES; MICE; MICE, INBRED C57BL; MUCOPOLYSACCHARIDOSIS III; NEURODEGENERATIVE DISEASES; NEURONS; PROTEIN KINASE INHIBITORS;

EID: 78649866475     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014192     Document Type: Article

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