Exhaled breath condensate in children: Present knowledge and future prospects

Journal of Breath Research

Volumn 2, Issue 3, 2008, Pages

  Carraro, Silvia ^a   Baraldi, Eugenio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; 8 ISOPROSTANE; CORTICOSTEROID; HYDROGEN PEROXIDE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MALONALDEHYDE; NITRITE; PEPTIDOLEUKOTRIENE; STEROID;

ASTHMA; BREATH ANALYSIS; BREATHING RATE; CILIARY DYSKINESIA; CYSTIC FIBROSIS; DRUG EFFICACY; EXHALATION; EXPIRED AIR; HUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PH MEASUREMENT; PRIORITY JOURNAL; REVIEW; SLEEP DISORDERED BREATHING; STEROID THERAPY;

EID: 78649859780     PISSN: 17527155     EISSN: 17527163     Source Type: Journal    
DOI: 10.1088/1752-7155/2/3/037003     Document Type: Review

References (44)

1. Horvath I, Barnes P and Hunt J 2005 Exhaled breath condensate: methodological recommendations and unresolved questions Eur. Respir. J. 26 523-48
2. McCafferty J B, Bradshaw T A, Tate S, Greening A P and Innes J A 2004 Effects of breathing pattern and inspired air conditions on breath condensate volume, pH, nitrite, and protein concentrations Thorax 59 694-8
3. Corradi M, Rubinstein I, Andreoli R, Manini P, Caglieri A, Poli D, Alinovi R and Mutti A 2003 Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease Am. J. Respir. Crit. Care Med. 167 1380-6
4. Vaughan J, Ngamtrakulpanit L, Pajewski T, Turner R, Nguyen T, Smith A, Urban P, Hom S, Gaston B and Hunt J 2003 Exhaled breath condensate pH is a robust and reproducible assay of airway acidity Eur. Respir. J. 22 889-94
5. Schleiss M B, Holz O, Behnke M, Richter K, Magnussen H and Jorres R A 2000 The concentration of hydrogen peroxide in exhaled air depends on expiratory flow rate Eur. Respir. J. 16 1115-8
6. Goldoni M, Caglieri A, Andreoli R, Poli D, Manini P, Vettori M, Corradi M and Mutti A 2005 Influence of condensation temperature on selected exhaled breath parameters BMC Pulm. Med. 1 5-10
7. Effros R M, Dunning M B 3rd, Biller J and Shaker R 2004 The promise and perils of exhaled breath condensates Am. J. Physiol. Lung Cell Mol. Physiol. 287 L1073-80
8. Baraldi E, Ghiro L, Piovan V, Carraro S, Zacchello F and Zanconato S 2003 Safety and success of exhaled breath condensate collection in asthma Arch. Dis. Child. 88 358-60
9. Griese M, Latzin P and Beck J 2001 A noninvasive method to collect nasally exhaled air condensate in humans of all ages Eur. J. Clin. Invest. 31 915-20
10. Moeller A, Franklin P, Hall G, Horak F Jr, Wildhaber J and Stick S 2006 Measuring exhaled breath condensate in infants Pediatr. Pulmonol. 41 184-7
11. Corradi M, Folesani G, Andreoli R, Manini P, Piacentini G, Carraro S, Zanconato S and Baraldi E 2003 Aldehydes and glutathione in exhaled breath condensate of asthmatic children Am. J. Respir. Crit. Care Med. 167 395-9
12. Baraldi E, Ghiro L, Piovan V, Carraro S, Ciabattoni G, Barnes P J and Montuschi P 2003 Increased exhaled 8-isoprostane in childhood asthma Chest 124 25-31
13. Shahid S, Kharitonov S, Wilson N, Bush A and Barnes P 2005 Exhaled 8-isoprostane in childhood asthma Respir. Res. 6 79
14. Zanconato S, Carraro S, Corradi M, Alinovi R, Pasquale M F, Piacentini G, Zacchello F and Baraldi E 2004 Leukotrienes and 8-isoprostane in exhaled breath condensate of children with stable and unstable asthma J. Allergy Clin. Immunol. 113 257-63
15. Lex C, Zacharasiewicz A, Payne D, Wilson N, Nicholson A, Kharitonov S, Barnes P and Bush A 2006 Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study Respir. Res. 7 63
16. Montuschi P, Mondino C, Koch P, Barnes P and Ciabattoni G 2006 Effects of a leukotriene receptor antagonist on exhaled leukotriene E4 and prostanoids in children with asthma J. Allergy Clin. Immunol. 118 347-53
17. Mondino C, Ciabattoni G, Koch P, Pistelli R, Trové A, Barnes P J and Montuschi P 2004 Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children J. Allergy Clin. Immunol. 114 761-7
18. Carraro S, Corradi M, Zanconato S, Alinovi R, Pasquale M F, Zacchello F and Baraldi E 2005 Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise induced bronchoconstriction J. Allergy Clin. Immunol. 115 764-70
19. Shibata A, Katsunuma T, Tomikawa M, Tan A, Yuki K, Akashi K and Eto Y 2006 Increased leukotriene E4 in the exhaled breath condensate of children with mild asthma Chest 130 1718-22
20. Csoma Z, Kharitonov S, Balint B, Bush A, Wilson J and Barnes P 2002 Increased leukotrienes in exhaled breath condensate in childhood asthma Am. J. Respir. Crit. Care Med. 166 1345-9
21. Montuschi P, Martello S, Felli M, Mondino C, Barnes P J and Chiarotti M 2005 Liquid chromatography/mass spectrometry analysis of exhaled leukotriene B4 in asthmatic children Respir. Res. 6 119
22. Ratnawati, Morton J, Henry R and Thomas P 2006 Exhaled breath condensate nitrite/nitrate and pH in relation to pediatric asthma control and exhaled nitric oxide Pediatr. Pulmonol. 41 929-36
23. Nguyen T, Woo-Park J, Hess M, Goins M, Urban P, Vaughan J, Smith A and Hunt J 2005 Assaying all of the nitrogen oxides in breath modifies the interpretation of exhaled nitric oxide Vascul. Pharmacol. 43 379-84
24. Baraldi E, Giordano G, Pasquale F, Carraro S, Mandregan A, Bonetto G, Zacchello F and Zanconato S 2006 3-nitrotyrosine, a marker of nitrosative stress, is increased in breath condensate of allergic asthmatic children Allergy 61 90-6
25. Gaston B and Hunt J F 2002 How acidopneic is my patient? A new question in the pulmonary laboratory Am. J. Respir. Crit. Care Med. 165 101-7
26. Carraro S, Folesani G, Corradi M, Zanconato S, Gaston B and Baraldi E 2005 Acid-base equilibrium in exhaled breath condensate of allergic asthmatic children Allergy 60 206-10
27. Carpagnano G, Barnes P, Francis J, Wilson N, Bush A and Kharitonov S 2004 Breath condensate pH in children with cystic fibrosis and asthma: A new noninvasive marker of airway inflammation? Chest 125 2005-10
28. Robroeks C M, Rosias P P, van Vliet D, Jöbsis Q, Yntema J B, Brackel H J, Damoiseaux J G, den Hartog G M, Wodzig W K and Dompeling E 2008 Biomarkers in exhaled breath condensate indicate presence and severity of cystic fibrosis in children Pediatr. Allergy Immunol. Feb 27 (Epub ahead of print)
29. Bodini A, D'Orazio C, Peroni D, Corradi M, Folesani G, Baraldi E, Assael B, Boner A and Piacentini G 2003 Biomarkers of neutrophilic inflammation in exhaled air of cystic fibrosis children with bacterial airway infections Pediatr. Pulmonol. 36 348-52
30. Vogelberg C, Hirsch T, Rosen-Wolff A, Kerkmann M and Leupold M 2003 Diagnostic and therapeutic methods: Pseudomonas aeruginosa and Burkholderia cepacia cannot be detected by PCR in the breath condensate of patients with cystic fibrosis Pediatr. Pulmunol. 36 348-52
31. Jobsis Q, Raatgeep H, Schellekens S, Kroesbergen A, Hop W and de Jongste J 2000 Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment Eur. Respir. J. 16 95-100
32. Csoma Z, Bush A, Wilson N, Donnelly L, Balint B, Barnes P and Kharitonov S 2003 Nitric oxide metabolites are not reduced in exhaled breath condensate of patients with primary ciliary dyskinesia Chest 124 633-8
33. Zihlif N, Paraskakis E, Tripoli C, Lex C and Bush A 2006 Markers of airway inflammation in primary ciliary dyskinesia studied using exhaled breath condensate Pediatr. Pulmunol. 41 509-14
34. Goldbart A, Krishna J, Li R, Serpero L and Gozal D 2006 Inflammatory mediators in exhaled breath condensate of children with obstructive sleep apnea syndrome Chest 130 143-8
35. Bonetto G, Corradi M, Carraro S, Zanconato S, Alinovi R, Folesani G, Da Dalt L, Mutti A and Baraldi E 2006 Longitudinal monitoring of lung injury in children following chlorine exposure in a swimming pool Am. J. Respir. Crit. Care Med. 174 545-9
36. Montuschi P, Martello S, Felli M, Mondino C and Chiarotti M 2004 Ion trap liquid chromatography/tandem mass spectrometry analysis of leukotriene B4 in exhaled breath condensate Rapid Commun. Mass Spectrom. 18 2723-9
37. Carpenter C T, Price P V and Christman B W 1998 Exhaled breath condensate isoprostanes are elevated in patients with acute lung injury or ARDS Chest 114 1653-9
38. Paget-Brown A O, Ngamtrakulpanit L, Smith A, Bunyan D, Hom S, Nguyen A and Hunt J F 2006 Normative data for pH of exhaled breath condensate Chest 129 426-30
39. Zacharasiewicz A, Wilson N, Lex C, Li A, Kemp M, Donovan J, Hooper J, Kharitonov S A and Bush A 2004 Repeatability of sodium and chloride in exhaled breath condensates Pediatr. Pulmonol. 37 273-5
40. Montuschi P (ed) 2005 New Perspectives in Monitoring Lung Inflammation: Analysis of Exhaled Breath Condensate (Boca Raton, FL: CRC Press)
41. Montuschi P 2007 Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications Ther. Adv. Respir. Dis. 1 5-23
42. Zacharasiewicz A, Wilson N, Lex C, Erin E M, Li A M, Hansel T, Khan M and Bush A 2005 Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children Am. J. Respir. Crit. Care Med. 171 1077-82
43. Carraro S, Rezzi S, Raniero D, Heberger K, Giordano G, Zanconato S, Guillou C and Baraldi E 2007 Metabolomics applied to exhaled breath condensate in childhood asthma Am. J. Respir. Crit. Care Med. 175 986-90
44. Hunt J 2007 If it smells like a duck, it might be an asthma subphenotype Am. J. Respir. Crit. Care. Med. 175 975-6