Tetrahydrobiopterin does not affect end-organ responsiveness to norepinephrine-mediated vasoconstriction in aged skin

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 299, Issue 6, 2010, Pages

  Lang, James A ^a   Holowatz, Lacy A ^a   Kenney, W Larry ^a,b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b Graduate Physiology Program   (United States)

Author keywords

Adrenergic; Aging; Skin blood flow; Temperature regulation

Indexed keywords

BRETYLIUM TOSYLATE; NEUROTRANSMITTER; NORADRENALIN; TETRAHYDROBIOPTERIN;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; CLINICAL ARTICLE; CONDUCTANCE; CONTROLLED STUDY; CUTANEOUS PARAMETERS; FEMALE; HUMAN; IONTOPHORESIS; MALE; MICRODIALYSIS; NERVE ENDING; PRIORITY JOURNAL; SKIN BLOOD FLOW; SKIN TEMPERATURE; VASOCONSTRICTION;

ADULT; AGE FACTORS; AGED; ANALYSIS OF VARIANCE; BIOPTERIN; FEMALE; HUMANS; MALE; NOREPINEPHRINE; REGIONAL BLOOD FLOW; SKIN; SKIN AGING; SKIN PHYSIOLOGICAL PHENOMENA; SKIN TEMPERATURE; VASOCONSTRICTION;

EID: 78649851595     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00138.2010     Document Type: Article

References (41)

1. Blair DA, Glover WE, Kidd BS, Roddie IC. Peripheral vascular effects of bretylium tosylate in man. Br J Pharmacol Chemother 15: 466-475, 1960.
2. 2-receptor antagonist yohimbine. J Hypertens 19: 907-911, 2001.
3. Collins KJ, Dore C, Exton-Smith AN, Fox RH, MacDonald IC, Woodward PM. Accidental hypothermia and impaired temperature homoeostasis in the elderly. Br Med J 1: 353-356, 1977.
4. Cosentino F, Hurlimann D, Delli Gatti C, Chenevard R, Blau N, Alp NJ, Channon KM, Eto M, Lerch P, Enseleit F, Ruschitzka F, Volpe M, Luscher TF, Noll G. Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia. Heart 94: 487-492, 2008.
5. Degroot DW, Kenney WL. Impaired defense of core temperature in aged humans during mild cold stress. Am J Physiol Regul Integr Comp Physiol 292: R103-R108, 2007.
6. Delp MD, Behnke BJ, Spier SA, Wu G, Muller-Delp JM. Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles. J Physiol 586: 1161-1168, 2008.
7. Dinenno FA, Dietz NM, Joyner MJ. Aging and forearm postjunctional α-adrenergic vasoconstriction in healthy men. Circulation 106: 1349-1354, 2002.
8. Duff HJ, Roden DM, Yacobi A, Robertson D, Wang T, Maffucci RJ, Oates JA, Woosley RL. Bretylium: relations between plasma concentrations and pharmacologic actions in high-frequency ventricular arrhythmias. Am J Cardiol 55: 395-401, 1985.
9. Dunkley PR, Bobrovskaya L, Graham ME, von Nagy-Felsobuki EI, Dickson PW. Tyrosine hydroxylase phosphorylation: regulation and consequences. J Neurochem 91: 1025-1043, 2004.
10. Durand S, Davis SL, Cui J, Crandall CG. Exogenous nitric oxide inhibits sympathetically mediated vasoconstriction in human skin. J Physiol 562: 629-634, 2005.
11. Durand S, Fromy B, Bouye P, Saumet JL, Abraham P. Current-induced vasodilation during water iontophoresis (5 min, 0.10 mA) is delayed from current onset and involves aspirin sensitive mechanisms. J Vasc Res 39: 59-71, 2002. (Pubitemid 34158360)
12. Eskurza I, Myerburgh LA, Kahn ZD, Seals DR. Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J Physiol 568: 1057-1065, 2005.
13. Gramsbergen JB, Sandberg M, Moller Dall A, Kornblit B, Zimmer J. Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin. Brain Res 935: 47-58, 2002.
14. Gronlund B, Gronlund L, Astrup A, Bie P, Christensen NJ. Determination of local catecholamine release by microdialysis. Int J Obes Relat Metab Disord 17, Suppl 3: S60-S62; 1993.
15. Gronlund B, Gronlund L, Christensen NJ. Subcutaneous noradrenaline concentration increase in normal subjects during cold exposure evaluated by microdialysis. Clin Physiol 14: 467-474, 1994.
16. Heales SJ, Blair JA, Meinschad C, Ziegler I. Inhibition of monocyte luminol-dependent chemiluminescence by tetrahydrobiopterin, and the free radical oxidation of tetrahydrobiopterin, dihydrobiopterin and dihydroneopterin. Cell Biochem Funct 6: 191-195, 1988.
17. Hodges GJ, Chiu C, Kosiba WA, Zhao K, Johnson JM. The effect of microdialysis needle trauma on cutaneous vascular responses in humans. J Appl Physiol 106: 1112-1118, 2009.
18. Hogikyan RV, Supiano MA. Arterial -adrenergic responsiveness is decreased and SNS activity is increased in older humans. Am J Physiol Endocrinol Metab 266: E717-E724, 1994.
19. Katusic ZS, d'Uscio LV, Nath KA. Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects. Trends Pharmacol Sci 30: 48-54, 2009.
20. Kaufman S. Establishment of tetrahydrobiopterin as the hydroxylase cofactor and a review of some recent studies in man. Psychopharmacol Bull 14: 38-40, 1978.
21. Kenney WL, Armstrong CG. Reflex peripheral vasoconstriction is diminished in older men. J Appl Physiol 80: 512-515, 1996.
22. Kumer SC, Vrana KE. Intricate regulation of tyrosine hydroxylase activity and gene expression. J Neurochem 67: 443-462, 1996.
23. Kuzkaya N, Weissmann N, Harrison DG, Dikalov S. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J Biol Chem 278: 22546-22554, 2003.
24. Lang JA, Holowatz LA, Kenney WL. Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans. J Physiol 587: 3967-3974, 2009.
25. Lang JA, Holowatz LA, Kenney WL. Localized tyrosine or tetrahydrobiopterin supplementation corrects the age-related decline in cutaneous vasoconstriction. J Physiol 588: 1361-1368, 2010.
26. Lang JA, Jennings JD, Holowatz LA, Kenney WL. Reflex vasoconstriction in aged human skin increasingly relies on rho-kinase dependent mechanisms during whole body cooling. Am J Physiol Heart Circ Physiol 297: H1792-H1797, 2009.
27. Leis S, Drenkhahn S, Schick C, Arnolt C, Schmelz M, Birklein F, Bickel A. Catecholamine release in human skin-a microdialysis study. Exp Neurol 188: 86-93, 2004.
28. Li W, Knowlton D, Woodward WR, Habecker BA. Regulation of noradrenergic function by inflammatory cytokines and depolarization. J Neurochem 86: 774-783, 2003.
29. Moens AL, Kass DA. Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease. J Cardiovasc Pharmacol 50: 238-246, 2007. (Pubitemid 47428970)
30. Ross HA, van Gurp PJ, Willemsen JJ, Lenders JW, Tack CJ, Sweep FC. Transport within the interstitial space, rather than membrane permeability, determines norepinephrine recovery in microdialysis. J Pharmacol Exp Ther 319: 840-846, 2006.
31. Shibasaki M, Durand S, Davis SL, Cui J, Low DA, Keller DM, Crandall CG. Endogenous nitric oxide attenuates neutrally mediated cutaneous vasoconstriction. J Physiol 585: 627-634, 2007.
32. Shibasaki M, Low DA, Davis SL, Crandall CG. Nitric oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine. J Appl Physiol 105: 1504-1508, 2008.
33. Snyder DL, Aloyo VJ, Wang W, Roberts J. Influence of age and dietary restriction on norepinephrine uptake into cardiac synaptosomes. J Cardiovasc Pharmacol 32: 896-901, 1998. (Pubitemid 28563911)
34. Thompson-Torgerson CS, Holowatz LA, Flavahan NA, Kenney WL. Rho kinase-mediated local cold-induced cutaneous vasoconstriction is augmented in aged human skin. Am J Physiol Heart Circ Physiol 293: H30-H36, 2007.
35. Thompson CS, Holowatz LA, Kenney WL. Attenuated noradrenergic sensitivity during local cooling in aged human skin. J Physiol 564: 313-319, 2005.
36. Thompson CS, Holowatz LA, Kenney WL. Cutaneous vasoconstrictor responses to norepinephrine are attenuated in older humans. Am J Physiol Regul Integr Comp Physiol 288: R1108-R1113, 2005.
37. Thompson CS, Kenney WL. Altered neurotransmitter control of reflex vasoconstriction in aged human skin. J Physiol 558: 697-704, 2004.
38. Urano F, Hayashi N, Arisaka F, Kurita H, Murata S, Ichinose H. Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: formation of insoluble aggregates of tyrosine hydroxylase. J Biochem 139: 625-635, 2006.
39. Williams A, Ballenger J, Levine R, Lovenberg W, Calne D. Aging and CSF hydroxylase cofactor. Neurology 30: 1244-1246, 1980.
40. Wilson TE, Monahan KD, Short DS, Ray CA. Effect of age on cutaneous vasoconstrictor responses to norepinephrine in humans. Am J Physiol Regul Integr Comp Physiol 287: R1230-R1234, 2004.
41. Zigmond RE, Schwarzschild MA, Rittenhouse AR. Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation. Annu Rev Neurosci 12: 415-461, 1989.