Mitotic DNA damage targets the Aurora A/TPX2 complex

Cell Cycle

Volumn 9, Issue 22, 2010, Pages 4592-4599

  Bhatia, Payal ^a   Menigatti, Mirco ^a   Brocard, Michele ^b   Morley, Simon ^b   Ferrari, Stefano ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Aurora A; DNA damage; Mitosis; TPX2; Translation

Indexed keywords

AURORA A KINASE; MESSENGER RNA; PROTEIN; PROTEIN TPX2; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HELA CELL; IONIZING RADIATION; MITOSIS; PROTEIN DEPHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

EID: 78649804693     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.22.13665     Document Type: Article

References (48)

1. Loeb LA, Loeb KR, Anderson JP. Multiple mutations and cancer. Proc Natl Acad Sci USA 2003; 100:776-81.
2. Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009; 461:1071-8.
3. Mikhailov A, Shinohara M, Rieder CL. The p38-mediated stress-activated checkpoint. A rapid response system for delaying progression through antephase and entry into mitosis. Cell Cycle 2005; 4:57-62.
4. Chin CF, Yeong FM. Safeguarding entry into mitosis: the antephase checkpoint. Mol Cell Biol 2010; 30:22-32.
5. Rieder CL, Cole RW. Entry into mitosis in vertebrate somatic cells is guarded by a chromosome damage checkpoint that reverses the cell cycle when triggered during early but not late prophase. J Cell Biol 1998; 142:1013-22.
6. 2-M transition in vertebrates. Curr Biol 2000; 10:1067-70.
7. Matsusaka T, Pines J. Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells. J Cell Biol 2004; 166:507-16.
8. 2/M transition by triggering the p38 MAPK checkpoint pathway. J Cell Biol 2004; 166:517-26.
9. Scolnick DM, Halazonetis TD. Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature 2000; 406:430-5.
10. Mikhailov A, Cole RW, Rieder CL. DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint. Curr Biol 2002; 12:1797-806.
11. Choi E, Lee H. Chromosome damage in mitosis induces BubR1 activation and prometaphase arrest. FEBS Lett 2008; 582:1700-6.
12. Chow JP, Siu WY, Fung TK, Chan WM, Lau A, Arooz T, et al. DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes and reverses cells to interphase. Mol Biol Cell 2003; 14:3989-4002.
13. Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, et al. An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. Nat Cell Biol 2009; 11:278-85.
14. Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. J Cell Sci 1999; 112:3591-601.
15. Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 1998; 17:3052-65.
16. Krystyniak A, Garcia-Echeverria C, Prigent C, Ferrari S. Inhibition of Aurora A in response to DNA damage. Oncogene 2006; 25:338-48.
17. Katayama H, Zhou H, Li Q, Tatsuka M, Sen S. Interaction and feedback regulation between STK15/ BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem 2001; 276:46219-24.
18. Hutterer A, Berdnik D, Wirtz-Peitz F, Zigman M, Schleiffer A, Knoblich JA. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev Cell 2006; 11:147-57.
19. Chan EH, Santamaria A, Sillje HH, Nigg EA. Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora. Chromosoma 2008.
20. Eyers PA, Erikson E, Chen LG, Maller JL. A novel mechanism for activation of the protein kinase aurora a. Curr Biol 2003; 13:691-7.
21. Eckerdt F, Pascreau G, Phistry M, Lewellyn AL, DePaoli-Roach AA, Maller JL. Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A. Cell Cycle 2009; 8:2413-9.
22. Bayliss R, Sardon T, Vernos I, Conti E. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell 2003; 12:851-62.
23. Pugacheva EN, Golemis EA. The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat Cell Biol 2005; 7:937-46.
24. Zhao ZS, Lim JP, Ng YW, Lim L, Manser E. The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol Cell 2005; 20:237-49.
25. Ferrari S, Marin O, Pagano MA, Meggio F, Hess D, El-Shemerly M, et al. Aurora-A site specificity: a study with synthetic peptide substrates. Biochem J 2005; 390:293-302.
26. Ohashi S, Sakashita G, Ban R, Nagasawa M, Matsuzaki H, Murata Y, et al. Phospho-regulation of human protein kinase Aurora-A: analysis using anti-phospho- Thr288 monoclonal antibodies. Oncogene 2006; 25:7691-702.
27. Littlepage LE, Wu H, Andresson T, Deanehan JK, Amundadottir LT, Ruderman JV. Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A. Proc Natl Acad Sci USA 2002; 99:15440-5.
28. Walter AO, Seghezzi W, Korver W, Sheung J, Lees E. The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation. Oncogene 2000; 19:4906-16.
29. Wu JQ, Guo JY, Tang W, Yang CS, Freel CD, Chen C, et al. PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat Cell Biol 2009; 11:644-51.
30. Stewart S, Fang G. Anaphase-promoting complex/ cyclosome controls the stability of TPX2 during mitotic exit. Mol Cell Biol 2005; 25:10516-27.
31. 2 DNA-damage-response checkpoint. Cell 2008; 134:256-67.
32. Ferrari S. Protein kinases controlling the onset of mitosis. Cell Mol Life Sci 2006; 63:781-95.
33. Bischoff JR, Plowman GD. The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. Trends Cell Biol 1999; 9:454-9.
34. Johnson LN, Lewis RJ. Structural basis for control by phosphorylation. Chem Rev 2001; 101:2209-42.
35. Rape M, Reddy SK, Kirschner MW. The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell 2006; 124:89-103.
36. Clute P, Pines J. Temporal and spatial control of cyclin B1 destruction in metaphase. Nat Cell Biol 1999; 1:82-7.
37. Drapkin BJ, Lu Y, Procko AL, Timney BL, Cross FR. Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin. Mol Syst Biol 2009; 5:328.
38. Groisman I, Huang YS, Mendez R, Cao Q, Theurkauf W, Richter JD. CPEB, maskin and cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division. Cell 2000; 103:435-47.
39. Stutz A, Conne B, Huarte J, Gubler P, Volkel V, Flandin P, et al. Masking, unmasking and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes. Genes Dev 1998; 12:2535-48.
40. Blower MD, Feric E, Weis K, Heald R. Genome-wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules. J Cell Biol 2007; 179:1365-73.
41. Eliscovich C, Peset I, Vernos I, Mendez R. Spindlelocalized CPE-mediated translation controls meiotic chromosome segregation. Nat Cell Biol 2008; 10:858-65.
42. Mendez R, Hake LE, Andresson T, Littlepage LE, Ruderman JV, Richter JD. Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA. Nature 2000; 404:302-7.
43. Sarkissian M, Mendez R, Richter JD. Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3. Genes Dev 2004; 18:48-61.
44. Cao Q, Richter JD. Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)- binding protein controls cyclin B1 mRNA translation and oocyte maturation. EMBO J 2002; 21:3852-62.
45. Le Breton M, Belle R, Cormier P, Mulner-Lorillon O, Morales J. M-phase regulation of the recruitment of mRNAs onto polysomes using the CDK1/cyclin B inhibitor aminopurvalanol. Biochem Biophys Res Commun 2003; 306:880-6.
46. Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, et al. Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol 2002; 12:1279-86.
47. Lemaire M, Ducommun B, Nebreda AR. UV-induced downregulation of the CDC25B protein in human cells. FEBS Lett 2010; 584:1199-204.
48. Naegele S, Morley SJ. Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress. J Biol Chem 2004; 279:46023-34.