메뉴 건너뛰기




Volumn 4, Issue 11, 2010, Pages

Midgut barrier imparts selective resistance to filarial worm infection in Culex Pipiens Pipiens

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; PAPAIN;

EID: 78649791159     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000875     Document Type: Article
Times cited : (23)

References (48)
  • 1
    • 0029962945 scopus 로고    scopus 로고
    • Reassessing the global prevalence and distribution of lymphatic filariasis
    • Michael E, Bundy DA, Grenfell BT (1996) Reassessing the global prevalence and distribution of lymphatic filariasis. Parasitology 112: 409-428.
    • (1996) Parasitology , vol.112 , pp. 409-428
    • Michael, E.1    Bundy, D.A.2    Grenfell, B.T.3
  • 2
    • 0034410939 scopus 로고    scopus 로고
    • Pathogenesis of lymphatic disease in bancroftian filariasis: A clinical perspective
    • Dreyer G, Noroes J, Figueredo-Silva J, Piessens W (2000) Pathogenesis of lymphatic disease in bancroftian filariasis: a clinical perspective. Parasitol Today 16: 544-548.
    • (2000) Parasitol Today , vol.16 , pp. 544-548
    • Dreyer, G.1    Noroes, J.2    Figueredo-Silva, J.3    Piessens, W.4
  • 3
    • 20444396572 scopus 로고    scopus 로고
    • Physical and psychosocial burden due to lymphatic filariasis as perceived by patients and medical experts
    • Krishna Kumari A, Harichandrakumar K, Das LK, Krishnamoorthy K (2005) Physical and psychosocial burden due to lymphatic filariasis as perceived by patients and medical experts. Trop Med Int Health 10: 567-573.
    • (2005) Trop Med Int Health , vol.10 , pp. 567-573
    • Krishna Kumari, A.1    Harichandrakumar, K.2    Das, L.K.3    Krishnamoorthy, K.4
  • 4
    • 56149125119 scopus 로고    scopus 로고
    • The global programme to eliminate lymphatic filariasis: Health impact after 8 years
    • Ottesen E, Hooper P, Bradley M, Biswas G (2008) The global programme to eliminate lymphatic filariasis: health impact after 8 years. PLoS Negl Trop Dis 2: e317.
    • (2008) PLoS Negl Trop Dis , vol.2
    • Ottesen, E.1    Hooper, P.2    Bradley, M.3    Biswas, G.4
  • 5
    • 60549109516 scopus 로고    scopus 로고
    • Role of vector control in the global program to eliminate lymphatic filariasis
    • Bockarie M, Pedersen E, White G, Michael E (2009) Role of vector control in the global program to eliminate lymphatic filariasis. Annu Rev Entomol 54: 469-487.
    • (2009) Annu Rev Entomol , vol.54 , pp. 469-487
    • Bockarie, M.1    Pedersen, E.2    White, G.3    Michael, E.4
  • 6
    • 0347423041 scopus 로고    scopus 로고
    • Filariasis
    • Guerrant R, Walker D, Weller P, eds., Philadelphia: Churchill Livingston
    • Kazura JW (1999) Filariasis. In: Guerrant R, Walker D, Weller P, eds. Tropical Infectious Diseases. Philadelphia: Churchill Livingston. pp 852-860.
    • (1999) Tropical Infectious Diseases , pp. 852-860
    • Kazura, J.W.1
  • 7
    • 68949125022 scopus 로고    scopus 로고
    • Prolonged persistence of residual Wuchereria bancrofti infection after cessation of diethylcarbamazine-fortified salt programme
    • Ramaiah K, Thiruvengadam B, Vanamail P, Subramanian S, Gunasekaran S, et al. (2009) Prolonged persistence of residual Wuchereria bancrofti infection after cessation of diethylcarbamazine-fortified salt programme. Trop Med Int Health 14: 870-876.
    • (2009) Trop Med Int Health , vol.14 , pp. 870-876
    • Ramaiah, K.1    Thiruvengadam, B.2    Vanamail, P.3    Subramanian, S.4    Gunasekaran, S.5
  • 8
    • 77955920974 scopus 로고    scopus 로고
    • MicroRNAs: A role in drug resistance in parasitic nematodes
    • Devaney E, Winter A, Britton C (2010) microRNAs: a role in drug resistance in parasitic nematodes? Trends Parasitol 26: 428-433.
    • (2010) Trends Parasitol , vol.26 , pp. 428-433
    • Devaney, E.1    Winter, A.2    Britton, C.3
  • 9
    • 33544460563 scopus 로고
    • The epidemiology of filariasis due to Wuchereria bancrofti and Brugia malayi
    • Edeson JFB, Wilson T (1964) The epidemiology of filariasis due to Wuchereria bancrofti and Brugia malayi. Ann Rev Entomol 9: 245-268.
    • (1964) Ann Rev Entomol , vol.9 , pp. 245-268
    • Edeson, J.F.B.1    Wilson, T.2
  • 10
    • 0019194603 scopus 로고
    • Zoonotic implications of cats and dogs in filarial transmission in Peninsular Malaysia
    • Mak JW, Yen PK, Lim KC, Ramiah N (1980) Zoonotic implications of cats and dogs in filarial transmission in Peninsular Malaysia. Trop Geogr Med 32: 259-264.
    • (1980) Trop Geogr Med , vol.32 , pp. 259-264
    • Mak, J.W.1    Yen, P.K.2    Lim, K.C.3    Ramiah, N.4
  • 11
    • 78649794652 scopus 로고
    • Geographical distribution of arthropod-borne diseases and their principal vectors
    • White GB (1989) Geographical distribution of arthropod-borne diseases and their principal vectors. WHO Vector Biology Division 89.967.
    • (1989) WHO Vector Biology Division , vol.89 , pp. 967
    • White, G.B.1
  • 13
    • 0041722250 scopus 로고
    • A preliminary account of the transmission, maintenance and laboratory vectors of Brugia pahangi
    • Edeson JFB, Wharton RH, Laing ABG (1960) A preliminary account of the transmission, maintenance and laboratory vectors of Brugia pahangi. Trans Roy Soc Trop Med Hyg 54: 439-449.
    • (1960) Trans Roy Soc Trop Med Hyg , vol.54 , pp. 439-449
    • Edeson, J.F.B.1    Wharton, R.H.2    Laing, A.B.G.3
  • 14
    • 0141448815 scopus 로고    scopus 로고
    • Culex pipiens pipiens: Characterization of immune peptides and the influence of immune activation on development of Wuchereria bancrofti
    • Bartholomay L, Farid H, Ramzy R, Christensen B (2003) Culex pipiens pipiens: characterization of immune peptides and the influence of immune activation on development of Wuchereria bancrofti. Mol Biochem Parasitol 130: 43-50.
    • (2003) Mol Biochem Parasitol , vol.130 , pp. 43-50
    • Bartholomay, L.1    Farid, H.2    Ramzy, R.3    Christensen, B.4
  • 15
    • 78649797274 scopus 로고
    • Exsheathment of the microfilariae of Brugia pahangi in susceptible and refractory mosquitoes
    • Ewert A (1965) Exsheathment of the microfilariae of Brugia pahangi in susceptible and refractory mosquitoes. Am J Trop Med Hyg 14: 260-262.
    • (1965) Am J Trop Med Hyg , vol.14 , pp. 260-262
    • Ewert, A.1
  • 16
    • 72949109383 scopus 로고    scopus 로고
    • Distribution of Brugia malayi larvae and DNA in vector and non-vector mosquitoes: Implications for molecular diagnostics
    • Erickson S, Fischer K, Weil G, Christensen B, Fischer P (2009) Distribution of Brugia malayi larvae and DNA in vector and non-vector mosquitoes: implications for molecular diagnostics. Parasit Vectors 2: 56.
    • (2009) Parasit Vectors , vol.2 , pp. 56
    • Erickson, S.1    Fischer, K.2    Weil, G.3    Christensen, B.4    Fischer, P.5
  • 17
    • 0017763793 scopus 로고
    • The fate of ingested Brugia pahangi microfilariae in susceptible and refractory strains of Culex pipiens and Aedes aegypti
    • Obiamiwe B (1977) The fate of ingested Brugia pahangi microfilariae in susceptible and refractory strains of Culex pipiens and Aedes aegypti. Ann Trop Med Parasitol 71: 375-377.
    • (1977) Ann Trop Med Parasitol , vol.71 , pp. 375-377
    • Obiamiwe, B.1
  • 18
    • 0021739512 scopus 로고
    • Defense reactions of mosquitoes to filarial worms: Comparative studies on the response of three different mosquitoes to inoculated Brugia pahangi and Dirofilaria immitis microfilariae
    • Christensen BM, Sutherland DR, Gleason LN (1984) Defense reactions of mosquitoes to filarial worms: comparative studies on the response of three different mosquitoes to inoculated Brugia pahangi and Dirofilaria immitis microfilariae. J Invertebr Pathol 44: 267-274.
    • (1984) J Invertebr Pathol , vol.44 , pp. 267-274
    • Christensen, B.M.1    Sutherland, D.R.2    Gleason, L.N.3
  • 19
    • 0019740136 scopus 로고
    • Observations on the immune response of Aedes trivittatus against Dirofilaria immitis
    • Christensen B (1981) Observations on the immune response of Aedes trivittatus against Dirofilaria immitis. Trans R Soc Trop Med Hyg 75: 439-443.
    • (1981) Trans R Soc Trop Med Hyg , vol.75 , pp. 439-443
    • Christensen, B.1
  • 20
    • 0024511628 scopus 로고
    • Brugia malayi and Brugia pahangi: Inherent difference in immune activation in the mosquitoes Armigeres subalbatus and Aedes aegypti
    • Beernsten BT, Luckhart S, Christensen BM (1989) Brugia malayi and Brugia pahangi: Inherent difference in immune activation in the mosquitoes Armigeres subalbatus and Aedes aegypti. J Parasitol 75: 76-81.
    • (1989) J Parasitol , vol.75 , pp. 76-81
    • Beernsten, B.T.1    Luckhart, S.2    Christensen, B.M.3
  • 21
    • 0002272352 scopus 로고
    • Brugia pahangi: Exsheathment and midgut penetration in Aedes aegypti
    • Christensen BM, Sutherland DR (1984) Brugia pahangi: Exsheathment and midgut penetration in Aedes aegypti. Trans Amer Microscop Soc 103: 423-433.
    • (1984) Trans Amer Microscop Soc , vol.103 , pp. 423-433
    • Christensen, B.M.1    Sutherland, D.R.2
  • 22
    • 33847081218 scopus 로고    scopus 로고
    • Penetration of the mosquito midgut is not required for Brugia pahangi microfilariae to avoid the melanotic encapsulation response of Armigeres subalbatus
    • Beerntsen B, Bartholomay L, Lowery R (2007) Penetration of the mosquito midgut is not required for Brugia pahangi microfilariae to avoid the melanotic encapsulation response of Armigeres subalbatus. Vet Parasitol 144: 371-374.
    • (2007) Vet Parasitol , vol.144 , pp. 371-374
    • Beerntsen, B.1    Bartholomay, L.2    Lowery, R.3
  • 23
    • 0030198769 scopus 로고    scopus 로고
    • Aedes aegypti: Induced antibacterial proteins reduce the establishment and development of Brugia malayi
    • Lowenberger CA, Ferdig MT, Bulet P, Khalili S, Hoffmann JA, et al. (1996) Aedes aegypti: induced antibacterial proteins reduce the establishment and development of Brugia malayi. Exp Parasitol 83: 191-201.
    • (1996) Exp Parasitol , vol.83 , pp. 191-201
    • Lowenberger, C.A.1    Ferdig, M.T.2    Bulet, P.3    Khalili, S.4    Hoffmann, J.A.5
  • 24
    • 0018731626 scopus 로고
    • The exsheathment of Brugia pahangi microfilariae under controlled conditions in vitro
    • Devaney E, Howells R (1979) The exsheathment of Brugia pahangi microfilariae under controlled conditions in vitro. Ann Trop Med Parasitol 73: 227-233.
    • (1979) Ann Trop Med Parasitol , vol.73 , pp. 227-233
    • Devaney, E.1    Howells, R.2
  • 25
    • 0043224886 scopus 로고
    • Comparative migration of microfilariae and development of Brugia pahangi in various mosquitoes
    • Ewert A (1965) Comparative migration of microfilariae and development of Brugia pahangi in various mosquitoes. Am J Trop Med Hyg 14: 254-259.
    • (1965) Am J Trop Med Hyg , vol.14 , pp. 254-259
    • Ewert, A.1
  • 26
    • 0030119114 scopus 로고    scopus 로고
    • Host-parasite relationships of Wuchereria bancrofti and mosquito hosts, Culex pipiens L. and Aedes caspius pallas
    • Gad AM, Farid H, Hammad R, Hussein M, Kaschef A (1996) Host-parasite relationships of Wuchereria bancrofti and mosquito hosts, Culex pipiens L. and Aedes caspius pallas. J Egypt Soc Parasitol 26: 93-104.
    • (1996) J Egypt Soc Parasitol , vol.26 , pp. 93-104
    • Gad, A.M.1    Farid, H.2    Hammad, R.3    Hussein, M.4    Kaschef, A.5
  • 27
    • 0017760787 scopus 로고
    • Susceptibility to Brugia pahangi of geographical strains of Culex pipiens fatigans
    • Obiamiwe B (1977) Susceptibility to Brugia pahangi of geographical strains of Culex pipiens fatigans. Ann Trop Med Parasitol 71: 367-370.
    • (1977) Ann Trop Med Parasitol , vol.71 , pp. 367-370
    • Obiamiwe, B.1
  • 28
    • 0014557341 scopus 로고
    • The laboratory infection of Culex pipiens complex with Brugia pahangi
    • Ogunba EO (1969) The laboratory infection of Culex pipiens complex with Brugia pahangi. J Med Entomol 6: 331-333.
    • (1969) J Med Entomol , vol.6 , pp. 331-333
    • Ogunba, E.O.1
  • 29
    • 0017661284 scopus 로고
    • Structure and function of midgut epithelial cells in culicidae mosquitoes (Insecta, Diptera)
    • Hecker H (1977) Structure and function of midgut epithelial cells in culicidae mosquitoes (Insecta, Diptera). Cell Tissue Res 184: 321-341.
    • (1977) Cell Tissue Res , vol.184 , pp. 321-341
    • Hecker, H.1
  • 30
    • 0015811593 scopus 로고
    • Structure and function of the basal lamina and of the cell junctions in the midgut epithelium (stomach) of female Aedes aegypti L.(Insecta, Diptera)
    • Reinhardt C, Hecker H (1973) Structure and function of the basal lamina and of the cell junctions in the midgut epithelium (stomach) of female Aedes aegypti L.(Insecta, Diptera). Acta Trop 30: 213-236.
    • (1973) Acta Trop , vol.30 , pp. 213-236
    • Reinhardt, C.1    Hecker, H.2
  • 31
    • 3543089900 scopus 로고    scopus 로고
    • How do mosquito vectors live with their viruses?
    • Gillespie SH, Smith GL, Osbourn A, eds., Cambridge, UK: Cambridge University Press
    • Higgs S (2004) How do mosquito vectors live with their viruses? In: Gillespie SH, Smith GL, Osbourn A, eds. Microbe-Vector Interactions in Vector-Borne Diseases. Cambridge, UK: Cambridge University Press. pp 103-138.
    • (2004) Microbe-Vector Interactions In Vector-Borne Diseases , pp. 103-138
    • Higgs, S.1
  • 32
    • 10744226226 scopus 로고    scopus 로고
    • The dynamics of interactions between Plasmodium and the mosquito: A study of the infectivity of Plasmodium berghei and Plasmodium gallinaceum, and their transmission by Anopheles stephensi, Anopheles gambiae and Aedes aegypti
    • Alavi Y, Arai M, Mendoza J, Tufet-Bayona M, Sinha R, et al. (2003) The dynamics of interactions between Plasmodium and the mosquito: a study of the infectivity of Plasmodium berghei and Plasmodium gallinaceum, and their transmission by Anopheles stephensi, Anopheles gambiae and Aedes aegypti. Int J Parasitol 33: 933-943.
    • (2003) Int J Parasitol , vol.33 , pp. 933-943
    • Alavi, Y.1    Arai, M.2    Mendoza, J.3    Tufet-Bayona, M.4    Sinha, R.5
  • 33
    • 0031194579 scopus 로고    scopus 로고
    • Interactions of human malaria parasites, Plasmodium vivax and P.falciparum, with the midgut of Anopheles mosquitoes
    • Ramasamy M, Kulasekera R, Wanniarachchi I, Srikrishnaraj K, Ramasamy R (1997) Interactions of human malaria parasites, Plasmodium vivax and P.falciparum, with the midgut of Anopheles mosquitoes. Med Vet Entomol 11: 290-296.
    • (1997) Med Vet Entomol , vol.11 , pp. 290-296
    • Ramasamy, M.1    Kulasekera, R.2    Wanniarachchi, I.3    Srikrishnaraj, K.4    Ramasamy, R.5
  • 34
    • 0029061943 scopus 로고
    • Plasmodium gallinaceum: A refractory mechanism of ookinete killing in the mosquito, Anopheles gambiae
    • Vernick K, Fujioka H, Seeley DC, Tandler B, Aikawa M, et al. (1995) Plasmodium gallinaceum: a refractory mechanism of ookinete killing in the mosquito, Anopheles gambiae. Exp Parasitol 80: 583-595.
    • (1995) Exp Parasitol , vol.80 , pp. 583-595
    • Vernick, K.1    Fujioka, H.2    Seeley, D.C.3    Tandler, B.4    Aikawa, M.5
  • 35
    • 0014189450 scopus 로고
    • Adaptation of a filarial worm, Brugia patei, to a new mosquito host, Aedes togoi
    • Laurence B, Pester FR (1967) Adaptation of a filarial worm, Brugia patei, to a new mosquito host, Aedes togoi. J Helminthol 41: 365-392.
    • (1967) J Helminthol , vol.41 , pp. 365-392
    • Laurence, B.1    Pester, F.R.2
  • 36
    • 0347221432 scopus 로고
    • Laboratory studies on the immune response of Aedes trivittatus against Dirofilaria immitis
    • Christensen BM (1977) Laboratory studies on the immune response of Aedes trivittatus against Dirofilaria immitis. Mosquito News 37: 367-372.
    • (1977) Mosquito News , vol.37 , pp. 367-372
    • Christensen, B.M.1
  • 37
    • 0029047466 scopus 로고
    • Susceptibility of various mosquitoes of California to subperiodic Brugia malayi
    • Bangs M, Ash LR, Barr AR (1995) Susceptibility of various mosquitoes of California to subperiodic Brugia malayi. Acta Trop 59: 323-332.
    • (1995) Acta Trop , vol.59 , pp. 323-332
    • Bangs, M.1    Ash, L.R.2    Barr, A.R.3
  • 38
    • 0028430581 scopus 로고
    • Chromosomal mapping of two loci affecting filarial worm susceptibility in Aedes aegypti
    • Severson D, Mori A, Zhang Y, Christensen B (1994) Chromosomal mapping of two loci affecting filarial worm susceptibility in Aedes aegypti. Insect Mol Biol 3: 67-72.
    • (1994) Insect Mol Biol , vol.3 , pp. 67-72
    • Severson, D.1    Mori, A.2    Zhang, Y.3    Christensen, B.4
  • 39
    • 84975016461 scopus 로고
    • The selection of a strain of Aedes aegypti susceptible to infection with Brugia malayi
    • Macdonald WW (1962) The selection of a strain of Aedes aegypti susceptible to infection with Brugia malayi. Ann Trop Med Parasitol 56: 373-382.
    • (1962) Ann Trop Med Parasitol , vol.56 , pp. 373-382
    • Macdonald, W.W.1
  • 40
    • 0002001874 scopus 로고
    • The Influence of the Gene fm (Filarial Susceptibility, Brugia malayi) on the Susceptibility of Aedes aegypti to Seven Strains of Brugia, Wuchereria and Dirofilaria
    • Macdonald WW, Ramachandran CP (1965) The Influence of the Gene fm (Filarial Susceptibility, Brugia malayi) on the Susceptibility of Aedes aegypti to Seven Strains of Brugia, Wuchereria and Dirofilaria. Ann Trop Med Parasitol 59: 64-73.
    • (1965) Ann Trop Med Parasitol , vol.59 , pp. 64-73
    • Macdonald, W.W.1    Ramachandran, C.P.2
  • 41
    • 0017699078 scopus 로고
    • The influence of the gene sb in Culex pipiens on the development of sub-periodic Brugia malayi and Wuchereria bancrofti
    • Obiamiwe B (1977) The influence of the gene sb in Culex pipiens on the development of sub-periodic Brugia malayi and Wuchereria bancrofti. Ann Trop Med Parasitol 71: 487-490.
    • (1977) Ann Trop Med Parasitol , vol.71 , pp. 487-490
    • Obiamiwe, B.1
  • 42
    • 78649794416 scopus 로고    scopus 로고
    • Selection of a strain of Culex pipiens highly susceptible to Wuchereria bancrofti
    • Farid HA, Hammad RE, Kamal SA, Christensen BM (2000) Selection of a strain of Culex pipiens highly susceptible to Wuchereria bancrofti. Egypt J Biol 2: 125-131.
    • (2000) Egypt J Biol , vol.2 , pp. 125-131
    • Farid, H.A.1    Hammad, R.E.2    Kamal, S.A.3    Christensen, B.M.4
  • 43
    • 0017596124 scopus 로고
    • On the inheritance of susceptibility for infection with Wuchereria bancrofti in Culex pipiens fatigans
    • Zielke E, Kuhlow F (1977) On the inheritance of susceptibility for infection with Wuchereria bancrofti in Culex pipiens fatigans. Tropenmed Parasitol 28: 68-70.
    • (1977) Tropenmed Parasitol , vol.28 , pp. 68-70
    • Zielke, E.1    Kuhlow, F.2
  • 44
    • 0020651771 scopus 로고
    • Intrinsic factors affecting vector competence of mosquitoes for arboviruses
    • Hardy JL, Houk EJ, Kramer LD, Reeves WC (1983) Intrinsic factors affecting vector competence of mosquitoes for arboviruses. Ann Rev Entomol 28: 229-262.
    • (1983) Ann Rev Entomol , vol.28 , pp. 229-262
    • Hardy, J.L.1    Houk, E.J.2    Kramer, L.D.3    Reeves, W.C.4
  • 45
    • 77951174893 scopus 로고    scopus 로고
    • Geographic and ecologic heterogeneity in elimination thresholds for the major vector-borne helminthic disease, lymphatic filariasis
    • Gambhir M, Bockarie M, Tisch D, Kazura J, Remais J, et al. (2010) Geographic and ecologic heterogeneity in elimination thresholds for the major vector-borne helminthic disease, lymphatic filariasis. BMC Biol 8: 22.
    • (2010) BMC Biol , vol.8 , pp. 22
    • Gambhir, M.1    Bockarie, M.2    Tisch, D.3    Kazura, J.4    Remais, J.5
  • 46
    • 51449096852 scopus 로고    scopus 로고
    • Complex ecological dynamics and eradicability of the vector borne macroparasitic disease, lymphatic filariasis
    • Gambhir M, Michael E (2008) Complex ecological dynamics and eradicability of the vector borne macroparasitic disease, lymphatic filariasis. PLoS One 3: e2874.
    • (2008) PLoS One , vol.3
    • Gambhir, M.1    Michael, E.2
  • 47
    • 33748678928 scopus 로고    scopus 로고
    • The argument for integrating vector control with multiple drug administration campaigns to ensure elimination of lymphatic filariasis
    • Burkot T, Durrheim D, Melrose W, Speare R, Ichimori K (2006) The argument for integrating vector control with multiple drug administration campaigns to ensure elimination of lymphatic filariasis. Filaria J 5: 10.
    • (2006) Filaria J , vol.5 , pp. 10
    • Burkot, T.1    Durrheim, D.2    Melrose, W.3    Speare, R.4    Ichimori, K.5
  • 48
    • 0034987627 scopus 로고    scopus 로고
    • Annual single-dose diethylcarbamazine plus ivermectin for control of bancroftian filariasis: Comparative efficacy with and without vector control
    • Reuben R, Rajendran R, Sunish I, Mani T, Tewari S, et al. (2001) Annual single-dose diethylcarbamazine plus ivermectin for control of bancroftian filariasis: comparative efficacy with and without vector control. Ann Trop Med Parasitol 95: 361-378.
    • (2001) Ann Trop Med Parasitol , vol.95 , pp. 361-378
    • Reuben, R.1    Rajendran, R.2    Sunish, I.3    Mani, T.4    Tewari, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.