Protein C and protein S changes in GH-deficient adults on r-HGH replacement therapy: Correlations with PAI-1 and t-PA plasma levels

Thrombosis Research

Volumn 126, Issue 6, 2010, Pages

  Di Minno, Matteo Nicola Dario ^a   Pezzullo, Salvatore ^a   Palmieri, Vittorio ^a   Di Somma, Carolina ^a   Lupoli, Roberta ^a   Valle, Domenico ^b   Lombardi, Gaetano ^a   Di Minno, Giovanni ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Eli Lilly and Co   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 9; FIBRINOGEN; HUMAN GROWTH HORMONE; INSULIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; PROTEIN S; PROTHROMBIN; SOMATOMEDIN BINDING PROTEIN 3; TISSUE PLASMINOGEN ACTIVATOR; VITAMIN K GROUP;

ADULT; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; HYPERCOAGULABILITY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PREDICTOR VARIABLE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VITAMIN BLOOD LEVEL;

ADULT; FEMALE; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; INSULIN; MALE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; PROTEIN S; RECOMBINANT PROTEINS; TISSUE PLASMINOGEN ACTIVATOR; VITAMIN K;

EID: 78649736863     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2010.08.028     Document Type: Article

References (19)

1. T. Rosen, and B.A. Bengtsson Premature mortality due to cardiovascular disease in hypopituitarism Lancet 336 1990 285 288
2. J.W. Tomlinson, N. Holden, R.K. Hills, K. Wheatley, R.N. Clayton, A.S. Bates, M.C. Sheppard, and P.M. Stewart Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group Lancet 9254 2001 425 431
3. A. Colao, C. Di Somma, F. Rota, R. Pivonello, M.C. Savanelli, S. Spiezia, and G. Lombardi Short-term effects of growth hormone (GH) replacement or deprivation on cardiovascular risk parameters and intima-media thickness at carotid arteries in patients with severe GH deficiency J Clin Endocrinol Metab 90 2005 2056 2062
4. D.E. Vaughan Plasminogen activator inhibitor-1 and the calculus of mortality after myocardial infarction Circulation 108 2003 376 377
5. J.U. Weaver, J.P. Monson, K. Noonan, W.G. John, A. Edwards, K.A. Evans, and J. Cunningham The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults J Clin Endocrinol Metab 80 1995 153 159
6. J.C. Smith, L.M. Evans, I. Wilkinson, J. Goodfellow, J.R. Cockcroft, M.F. Scanlon, and J.S. Davies Effects of GH replacement on endothelial function and large-artery stiffness in GH-deficient adults: a randomized, double-blind, placebo-controlled study Clin Endocrinol (Oxf) 56 2002 493 501
7. T.A. Elhadd, T.A. Abdu, J. Oxtoby, G. Kennedy, M. McLaren, R. Neary, J.J. Belch, and R.N. Clayton Biochemical and biophysical markers of endothelial dysfunction in adults with hypopituitarism and severe GH deficiency J Clin Endocrinol Metab 86 2001 4223 4232
8. A. Sartorio, M. Cattaneo, P. Bucciarelli, B. Bottasso, S. Porretti, P. Epaminonda, G. Faglia, and M. Arosio Alterations of haemostatic and fibrinolytic markers in adult patients with growth hormone deficiency and with acromegaly Exp Clin Endocrinol Diabetes 108 2000 486 492
9. J.M. Gomez, M. Sahun, R. Vila, P. Domenech, P. Catalina, J. Soler, and L. Badimon Peripheral fibrinolytic markers, soluble adhesion molecules, inflammatory cytokines and endothelial function in hypopituitary adults with growth hormone deficiency Clin Endocrinol (Oxf) 64 2006 632 639
10. J.H. Griffin, J.A. Fernandez, A.J. Gale, and L.O. Mosnier Activated protein C J Thromb Haemost 5 suppl 1 2007 73 80
11. M.N.D. Di Minno, E. Tremoli, A. Coppola, R. Lupoli, and G. Di Minno Homocysteine and arterial thrombosis: Challenge and opportunity Thromb Haemost 103 5 May 3 2010 942 961
12. N. Negrev, Y. Nyagolov, and E. Stanchewa Somatotropin and somatostatin effects on vitamin K-dependent plasma coagulation factors Eur J Pharmacol 24 277 1995 145 149
13. M.N.D. Di Minno, V. Palmieri, G. Lombardi, S. Pezzullo, F. Cirillo, C. Di Somma, D. Valle, and G. Di Minno Lack of change in insulin levels as a biological marker of PAI-1 lowering in GH-deficient adults on r-HGH replacement therapy Thromb Res 124 2009 711 713
14. A. Kehely, P.C. Bates, P. Frewer, M. Birkett, W.F. Blum, P. Mamessier, S. Ezzat, K.K. Ho, G. Lombardi, A. Luger, J. Marek, D. Russell-Jones, P. Sönksen, and A.F. Attanasio Short-term safety and efficacy of human GH replacement therapy in 595 adults with GH deficiency: a comparison of two dosage algorithms J Clin Endocrinol Metab 87 5 May 2002 1974 1979 PMID: 11994327 [PubMed - indexed for MEDLINE]
15. A.F. Attanasio, P.C. Bates, K.K. Ho, S.M. Webb, R.J. Ross, C.J. Strasburger, R. Bouillon, B. Crowe, K. Selander, D. Valle, and S.W. Lamberts Hypopituitary Control and Complications Study International Advisory Board. Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status - 3-year results from the HypoCCS Database J Clin Endocrinol Metab 87 2002 1600 1606
16. J.O. Johansson, K. Landin, L. Tengborn, T. Rosen, and B.A. Bengtsson High fibrinogen and plasminogen activator inhibitor activity in growth hormone-deficient adults Arterioscler Thromb 14 1994 434 437
17. J.O. Johansson, K. Landin, G. Johannsson, L. Tengborn, and B.A. Bengtsson Long-term treatment with growth hormone decreases plasminogen activator inhibitor-1 and tissue plasminogen activator in growth hormone-deficient adults Thromb Haemost 76 1996 422 428
18. D. Valle, M.N. Di Minno, V. Palmieri, S. Pezzullo, F. Cirillo, C. Di Somma, G. Di Minno, and G. Lombardi Changes in insulin levels following 6-month treatment with recombinant human growth hormone in growth hormone-deficient adults J Endocrinol Invest 32 11 Dec. 2009 908 912 [Epub 2009 Jul 17]
19. B. Hou, M. Eren, C.A. Painter, J.W. Covington, J.D. Dixon, J.A. Schoenhard, and D.E. Vaughan Tumor necrosis factor alpha activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor kappaB site J Biol Chem 279 2004 18127 18136