Antiproliferative and antioxidant properties of leaf extracts of Pereskia bleo (Cactaceae) and their ability to limit natural and oxidant-induced apoptotic cell death

Journal of Science and Technology in the Tropics

Volumn 6, Issue 1, 2010, Pages 31-38

  Er, Hui Meng ^a   Lee, Hong Lim ^a   Radhakrishnan, Ammu Kutty ^a  

^a INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

Author keywords

Anti proliferative; Antioxidant; Apoptotic cell death; Pereskia bleo leaf extracts

Indexed keywords

EID: 78649733736     PISSN: 18235034     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Goh K.L. (2000) Malaysian Herbaceous Plants. Millennium Edition. Advanco Press, Malaysia.
2. Tan M.L., Sulaiman S.F., Najimuddin N., Samian M.R. and Tengku Muhammad T.S. (2005) Methanolic extract of Pereskia bleo (Kunth) DC. (Cactaceae) induces apoptosis in breast carcinoma, T47-D cell line. Journal ofEthnopharmacology 96: 287-294. (Pubitemid 39575062)
3. Er HM, Cheng E. and Radhakrishnan A.K. (2007) Anti-proliferative and mutagenic activities of aqueous and methanol extracts of leaves from Pereskia bleo (Kunth) DC (Cactaceae). Journal of Ethnopharmacology 113: 448-456. (Pubitemid 47361564)
4. Abd Malek S.N., Abdul Wahab N., Yaacob H., Sim K.S., Hong S.L., Lee G.S. and Rahman S.N.S.A. (2008) Cytotoxic activity of Pereskia bleo (Cactaceae) against selected human cell lines. International Journal of Cancer Research 4: 20-27. (Pubitemid 350302678)
5. Wahab S.I.A., Abdul A.B., Mohan S.M., Al-Zubairi A.S., Elhassan MM. and Ibrahim M.Y. (2009) Biological activities of Pereskia bleo extracts. International Journal of Pharmacology 5: 71-75.
6. Lee H.L., Er H.M. and Radhakrishnan A.K. (2009) In vitro anti-proliferative and antioxidant activities of stem extracts of Pereskia bleo (Kunth) DC (Cactaceae). Malaysian Journal of Science 28: 225-239.
7. Ryter S.W., Kim H.P., Hoetzel A., Park J.W., Nakahira k., Wang X. and Choi A.M.K. (2007) Mechanisms of cell death in oxidative stress. Antioxidants and Redox Signaling 9: 49-89.
8. Larson R.A. (1988) The antioxidants of higher plants. Phytochemistry 27: 969-978.
9. Re R., Pellegrini N., Proteggente A., Pannala A., Yang M. and Rice-Evans C. (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine 26: 1231-1237.
10. Carmichael J., DeGraff W.G., Gazdar A.F., Minna J.D. and Mitchell J.B. (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radio sensitivity. Cancer Research 47: 943-946. (Pubitemid 17027906)
11. Geran R.I., Greenberg N.H., Macdonald M.M., Schumacher A.M. and Abbott B.J. (1972) Protocols for screening chemical agents and natural products against animal tumours and other biological system. Cancer Chemotherapy Reports 3: 59-61.
12. Kim H.W., Cho S.J., Kim B., Cho S.L. and Kim Y.K. (2010) Pogostemon cablin as ROS scavenger in oxidant-induced cell death of human neuroglioma cells. Evidence-based Complementary and Alternative Medicine 7: 239-247.
13. Widodo N., Kaur K., Shrestha B.G., Takagi Y., Ishii T., Whadhwa R. and Kaul S.C. (2007) Selective killing of cancer cells by leaf extract of Asgwagandga: Identification of a tumor-inhibitory factor and the first molecular insights to its effect. Clinical Cancer Research 13: 2298-2306.