The 'continuum of psychosis': Scientifically unproven and clinically impractical

British Journal of Psychiatry

Volumn 197, Issue 6, 2010, Pages 423-425

  Lawrie, Stephen M ^a   Hall, Jeremy ^a   McIntosh, Andrew M ^a   Owens, David G C ^a   Johnstone, Eve C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE SCHIZOAFFECTIVE PSYCHOSIS; AUTISM; BIPOLAR DISORDER; BIPOLAR II DISORDER; CHROMOSOME ABERRATION; CLINICAL ASSESSMENT; CLINICAL FEATURE; CLINICAL PRACTICE; COMORBIDITY; CONSENSUS; DEPRESSIVE PSYCHOSIS; DISEASE CLASSIFICATION; DRUG INDUCED PSYCHOSIS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC SUSCEPTIBILITY; HEALTH CARE SYSTEM; HEALTH CARE UTILIZATION; HERITABILITY; NEUROBIOLOGY; PATHOGENESIS; POLYPHARMACY; POST SCHIZOPHRENIC DEPRESSION; PRACTICE GUIDELINE; PRODROMAL SCHIZOPHRENIA; PSYCHIATRIC DIAGNOSIS; PSYCHIATRIC TREATMENT; PSYCHOSIS; REVIEW; SCHIZOPHRENIA; SYMPTOM; TAXONOMY;

DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; HUMANS; MENTAL DISORDERS;

EID: 78649730185     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.109.072827     Document Type: Review

References (21)

1. Tamminga CA, Sirovatka PJ, Regier DA, van Os J. Deconstructing Psychosis: Refining the Research Agenda for DSM-V. American Psychiatric Association, 2006.
2. Craddock N, Owen MJ. The beginning of the end for the Kraepelinian dichotomy. Br J Psychiatry 2005; 186: 364-6.
3. van Os J, Linscott RJ, Myin-Germeys I, Delespaul P, Krabbendam L. A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychol Med 2009; 39: 179-95.
4. Kendell RE. The Role of Diagnosis in Psychiatry. Blackwell, 1975.
5. Johnstone EC, Lawrie SM. An introduction to psychiatry. In Companion to Psychiatric Studies (eds EC Johnstone, DGC Owens, SM Lawrie, M Sharpe, A McIntosh). Churchill Livingstone, 2010.
6. Tandon R, Keshavan MS, Nasrallah HA. Schizophrenia, 'just the fact': what we know in 2008. Part 1: Overview. Schizophr Res 2008; 100; 4-19.
7. The International Schizophrenia Consortium. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009; 460: 748-52.
8. Kirkbride JB, Fearon P, Morgan C, Dazzan P, Morgan K, Tarrant J, et al. Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center AeSOP study. Arch Gen Psychiatry 2006; 63: 250-8.
9. Grozeva D, Kirov G, Ivanov D, Jones IR, Jones L, Green EK, et al. Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia. Arch Gen Psychiatry 2010; 67: 318-27.
10. McIntosh AM, Whalley HC, McKirdy J, Hall J, Sussmann JE, Shankar P, et al. Prefrontal function and activation in bipolar disorder and schizophrenia. Am J Psychiatry 2008; 165: 378-84.
11. Hall J, Whalley HC, Marwick K, McKirdy J, Sussmann J, Romaniuk L, et al. Hippocampal function in schizophrenia and bipolar disorder. Psychol Med 2010; 40: 761-70.
12. Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM. Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. Br J Psychiatry 2009; 195: 194-201.
13. Leucht S, Kissling W, McGrath J. Lithium for schizophrenia. Cochrane Database Syst Rev 2007; 3: CD003834.
14. Waller NG. Carving nature at its joints: Paul Meehl's development of taxometrics. J Abn Psychol 2006; 115: 210-5.
15. Bleuler E. Dementia Praecox, or the Group of Schizophrenias. International University Press, 1911.
16. Mojtabai R, Rieder RO. Limitations of the symptom-oriented approach to psychiatric research. Br J Psychiatry 1998; 173: 198-202.
17. Fletcher PC, Frith CD. Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia. Nat Rev Neurosci 2009; 10: 48-58.
18. Angst J. The bipolar spectrum. Br J Psychiatry 2007; 190: 189-91.
19. Blacker D, Tsuang MT. Contested boundaries of bipolar disorder and the limits of categorical diagnosis in psychiatry. Am J Psychiatry 1992; 149: 1473-83.
20. Linscott RJ, van Os J. Systematic reviews of categorical versus continuum models in psychosis: evidence for discontinuous subpopulations underlying a psychometric continuum. Implications for DSM-V, DSM-VI, and DSM-VII. Annu Rev Clin Psychol 2010; 6: 391-419.
21. David AS. Why we need more debate on whether psychotic symptoms lie on a continuum with normality. Psychol Med 2010; Feb 11: 1-8 (Epub ahead of print).