Lysophosphatidylcholines activate G2A inducing Gαi-1-/ Gαq/11- Ca2+ flux, Gβγ-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs

Biochemical Journal

Volumn 432, Issue 1, 2010, Pages 35-45

  Khan, Samina Y ^a,b   McLaughlin, Nathan J D ^a,b   Kelher, Marguerite R ^a,c   Eckels, Phillip ^c   Gamboni Robertson, Fabia ^c   Banerjee, Anirban ^c   Silliman, Christopher C ^a,b,c  

^a Bonfils Blood Center   (United States)

^b Children's Hospital Colorado   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Fluorescent resonance energy transfer (FRET); G protein coupled receptor; Intracellular neutralization; Neutrophil

Indexed keywords

ACUTE LUNG INJURY; ARRESTINS; BLOOD COMPONENT; CLATHRINS; CYTOSOLIC; DIGITAL MICROSCOPY; FLUORESCENT RESONANCE ENERGY TRANSFER; G PROTEIN; G PROTEIN COUPLED RECEPTORS; IMMUNOPRECIPITATIONS; INTRACELLULAR NEUTRALIZATION; KINASE ACTIVATION; NEUTROPHIL; PHYSICAL INTERACTIONS; POLYMORPHONUCLEAR LEUCOCYTES; RAPID ACTIVATION; SUBCELLULAR FRACTIONATION; WESTERN-BLOT ANALYSIS;

BACTERIOPHAGES; CALCIUM; CHEMICAL ACTIVATION; COMPUTER GRAPHICS; EMPLOYMENT; ENERGY TRANSFER; FLUORESCENCE; PHOSPHORYLATION; PROTEINS; RESONANCE; SIGNAL TRANSDUCTION;

MICROCOMPUTERS;

BETA ARRESTIN 1; CALCIUM ION; CLATHRIN; G PROTEIN COUPLED RECEPTOR KINASE 6; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; LYSOPHOSPHATIDYLCHOLINE;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; IMMUNOPRECIPITATION; MICROSCOPY; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSFUSION RELATED ACUTE LUNG INJURY; WESTERN BLOTTING;

ARRESTINS; BLOTTING, WESTERN; CALCIUM; CELL CYCLE PROTEINS; CELLS, CULTURED; CLATHRIN; CYTOSOL; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-PROTEIN-COUPLED RECEPTOR KINASES; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; ION TRANSPORT; LYSOPHOSPHATIDYLCHOLINES; MICROSCOPY, FLUORESCENCE; NEUTROPHILS; PHOSPHORYLATION; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-HCK; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 78649726865     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091087     Document Type: Article

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