Tissue integration of growth factor-eluting layer-by-layer polyelectrolyte multilayer coated implants

Biomaterials

Volumn 32, Issue 5, 2011, Pages 1446-1453

  Macdonald, Mara L ^a,b   Samuel, Raymond E ^b   Shah, Nisarg J ^b   Padera, Robert F ^d   Beben, Yvette M ^c   Hammond, Paula T ^b  

^a HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Bone morphogenetic protein 2 (BMP 2); Bone tissue engineering; Coating; Controlled drug release; Layer by Layer; Polyelectrolyte multilayer

Indexed keywords

BONE MORPHOGENETIC PROTEIN-2; BONE TISSUE ENGINEERING; CONTROLLED DRUG RELEASE; LAYER-BY-LAYERS; POLYELECTROLYTE MULTILAYER;

BONE; COATINGS; COMPUTERIZED TOMOGRAPHY; MULTILAYERS; PEPTIDES; PHOSPHATASES; POLYELECTROLYTES; SCAFFOLDS; TISSUE ENGINEERING; ULTRATHIN FILMS;

MULTILAYER FILMS;

ALIZARIN RED S; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CALCIUM PHOSPHATE; LAYER BY LAYER POLYELECTROLYTE; POLYCAPROLACTONE; POLYELECTROLYTE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN SECRETION; STEM CELL;

ANIMALS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELL LINE; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE ENGINEERING; X-RAY MICROTOMOGRAPHY;

EID: 78649724173     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.10.052     Document Type: Article

References (26)

1. Sheridan C. Fresh from the biologic pipeline-2009. Nat Biotechnol 2009, 28(4):307-310.
2. Lavernia C.J., Drakeford M.K., Tsao A.K., Gittelsohn A., Krackow K.A., Hungerford D.S. Revision and primary hip and knee arthroplasty - a cost-analysis. Clin Orthop Relat Res 1995, 311:136-141.
3. Fu K., Pack D.W., Klibanov A.M., Langer R. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm Res 2000, 17(1):100-106.
4. Jewell C.M., Lynn D.M. Multilayered polyelectrolyte assemblies as platforms for the delivery of DNA and other nucleic acid-based therapeutics. Adv Drug Deliv Rev 2008, 60(9):979-999.
5. Schneider A., Vodouhe C., Richert L., Francius G., Le Guen E., Schaaf P., et al. Multifunctional polyelectrolyte multilayer films: combining mechanical resistance, biodegradability, and bioactivity. Biomacromolecules 2007, 8(1):139-145.
6. Macdonald M., Rodriguez N.M., Smith R., Hammond P.T. Release of a model protein from biodegradable self assembled films for surface delivery applications. J Control Release 2008, 131(3):228-234.
7. Smith R.C., Riollano M., Leung A., Hammond P.T. Layer-by-Layer platform technology for small-molecule delivery. Angew Chem Int Ed 2009, 48(47):8974-8977.
8. Shukla A., Fleming K.E., Chuang H.F., Chau T.M., Loose C.R., Stephanopoulos G.N., et al. Controlling the release of peptide antimicrobial agents from surfaces. Biomaterials 2010, 31(8):2348-2357.
9. Wood K.C., Chuang H.e.l.e.n.F., Batten R.o.b.e.r.t.D., Lynn D.a.v.i.d.M., Hammond P.a.u.l.a.T. Controlling interlayer diffusion to achieve sustained, multiagent delivery from layer-by-layer thin films. Proc Natl Acad Sci 2006, 103(27):10207-10212.
10. Macdonald M.L., Rodriguez N.M., Shah N.J., Hammond P.T. Characterization of tunable FGF-2 releasing polyelectrolyte multilayers. Biomacromolecules 2010, 11(8):2053-2059.
11. Crouzier T., Ren K., Nicolas C., Roy C., Picart C. Layer-By-Layer films as a biomimetic reservoir for rhBMP-2 delivery: controlled differentiation of myoblasts to osteoblasts. Small 2009, 5(5):598-608.
12. Facca S., Cortez C., Mendoza-Palomares C., Messadeq N., Dierich A., Johnston A.P.R., et al. Active multilayered capsules for in vivo bone formation. Proc Natl Acad Sci 2010, 107(8):3406-3411.
13. Anderson D.G., Lynn D.M., Langer R. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed 2003, 42(27):3153-3158.
14. Lynn D.M., Langer R. Degradable poly(beta-amino esters): synthesis, characterization, and self-assembly with plasmid DNA. J Am Chem Soc 2000, 122(44):10761-10768.
15. Bragdon C.R., Jasty M., Greene M., Rubash H.E., Harris W.H. Biologic fixation of total hip implants - insights gained from a series of canine studies. J Bone Joint Surg Am 2004, 86A:105-117.
16. Gregory C.A., Gunn W.G., Peister A., Prockop D.J. An alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Anal Biochem 2004, 329(1):77-84.
17. Vazquez E., Dewitt D.M., Hammond P.T., Lynn D.M. Construction of hydrolytically-degradable thin films via layer-by-layer deposition of degradable polyelectrolytes. J Am Chem Soc 2002, 124(47):13992-13993.
18. Smith R.C., Leung A., Kim B.S., Hammond P.T. Hydrophobic effects in the critical destabilization and release dynamics of degradable multilayer films. Chem Mater 2009, 21(6):1108-1115.
19. Jourdainne L., Arntz Y., Senger B., Debry C., Voegel J.C., Schaaf P., et al. Multiple strata of exponentially growing polyelectrolyte multilayer films. Macromolecules 2007, 40(2):316-321.
20. Lavalle P., Gergely C., Cuisinier F.J.G., Decher G., Schaaf P., Voegel J.C., et al. Comparison of the structure of polyelectrolyte multilayer films exhibiting a linear and an exponential growth regime: an in situ atomic force microscopy study. Macromolecules 2002, 35(11):4458-4465.
21. Porcel C., Lavalle P., Ball V., Decher G., Senger B., Voegel J.C., et al. From exponential to linear growth in polyelectrolyte multilayers. Langmuir 2006, 22(9):4376-4383.
22. Porcel C., Lavalle P., Decher G., Senger B., Voegel J.C., Schaaf P. Influence of the polyelectrolyte molecular weight on exponentially growing multilayer films in the linear regime. Langmuir 2007, 23(4):1898-1904.
23. Chuang H.F., Smith R.C., Hammond P.T. Polyelectrolyte multilayers for tunable release of antibiotics. Biomacromolecules 2008, 9(6):1660-1668.
24. Degat M.C., Dubreucq G., Meunier A., Dahri-Correia L., Sedel L., Petite H., et al. Enhancement of the biological activity of BMP-2 by synthetic dextran derivatives. J Biomed Mater Res A 2009, 88A(1):174-183.
25. Lin H., Zhaol Y., Sun W.J., Chen B., Zhang J., Zhao W.X., et al. The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2. Biomaterials 2008, 29(9):1189-1197.
26. Uludag H., Gao T.J., Porter T.J., Friess W., Wozney J.M. Delivery systems for BMPs: factors contributing to protein retention at an application site. J Bone Joint Surg Am 2001, 83A:S128-S135.