Elevated oestrogen receptor splice variant ERαΔ5 expression in tumour-adjacent hormone-responsive tissue

International Journal of Environmental Research and Public Health

Volumn 7, Issue 11, 2010, Pages 3871-3889

  Taylor, Siân E ^a,b   Patel, Imran I ^a   Singh, Paras B ^a,b   Nicholson, Caroline M ^b   Stringfellow, Helen F ^b   Gopala Krishna, R K ^c   Matanhelia, Shyam S ^b   Martin Hirsch, Pierre L ^a,b   Martin, Francis L ^a  

^a LANCASTER UNIVERSITY   (United Kingdom)

^b LANCASHIRE TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c Wockhardt Hospitals   (India)

Author keywords

Endometrial cancer; Oestrogen receptor; Prostate cancer; Real time RT PCR; Splice variant

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHADELTA3; ESTROGEN RECEPTOR ALPHADELTA5; ESTROGEN RECEPTOR BETA1; ESTROGEN RECEPTOR BETA2; ESTROGEN RECEPTOR BETA5; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; INDIAN; MALE; PILOT STUDY; PROSTATE CANCER; REAL TIME POLYMERASE CHAIN REACTION; UNITED KINGDOM;

EID: 78649714541     PISSN: None     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph7113871     Document Type: Article

References (21)

1. Whittemore, A.S.; Kolonel, L.N.; Wu, A.H.; John, E.M.; Gallagher, R.P.; Howe, G.R.; Burch, J.D.; Hankin, J.; Dreon, D.M.; West, D.W.; Teh, C.-Z.; Paffenbarger, R.S, Prostate cancer in relation to diet, physical activity, and body size in Blacks, Whites, and Asians in the United States and Canada. J. Natl. Cancer Inst. 1995, 87, 652-661.
2. Dey, S.; Hablas, A.; Seifeldin, I.A.; Ismail, K.; Ramadan, M.; El-Hamzawy, H.; Wilson, M.L.; Banerjee, M.; Boffetta, P.; Harford, J.; Merajver, S.D.; Soliman, A.S. Urban-rural differences of gynaecological malignancies in Egypt (1999-2002). BJOG 2010, 117, 348-355.
3. Yang, C.-Y.; Hsieh, Y.-L. The Relationship between Population Density and Cancer Mortality in Taiwan. Jpn. J. Cancer Res. 1998, 89, 355-360.
4. Khan, N.; Afaq, F.; Mukhtar, H. Lifestyle as risk factor for cancer: Evidence from human studies. Cancer Lett. 2010, 293, 133-143.
5. Rieck, G.; Fiander, A. The effect of lifestyle factors on gynaecological cancer. Best Pract. Res. Clin. Obstet. Gynaecol. 2006, 20, 227-251.
6. Sorosky, J. Endometrial Cancer. Obstet. Gynecol. 2008, 111, 436-477.
7. Singh, P.B.; Matanhelia, S.S.; Martin, F.L. A potential paradox in prostate adenocarcinoma progression: Oestrogen as the initiating driver. Eur. J. Cancer 2008, 44, 928-936.
8. Setlur, S.R.; Mertz, K.D.; Hoshida, Y.; Demichelis, F.; Lupien, M.; Perner, S.; Sboner, A.; Pawitan, Y.; Andren, O.; Johnson, L.A.; Tang, J.; Adami, H.-O.; Calza, S.; Chinnaiyan, A.M.; Rhodes, D.; Tomlins, S.; Fall, K.; Mucci, L.A.; Kantoff, P.W.; Stampfer, M.J.; Andersson, S.-O.; Varenhorst, E.; Johansson, J.-E.; Brown, M.; Golub, T.R.; Rubin, M.A. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J. Natl. Cancer Inst. 2008, 100, 815-825.
9. Simpson, E.R.; Clyne, C; Rubin, G.; Boon, W.C.; Robertson, K.; Britt, K.; Speed, C; Jones, M. Aromatase - a brief overview. Annu. Rev. Physiol. 2002, 64, 93-127.
10. Taylor, S.E.; Martin-Hirsch, P.L.; Martin, F.L. Oestrogen receptor splice variants in the pathogenesis of disease. Cancer Lett. 2010, 288, 133-148.
11. Koduri, S.; Goldhar, A.S.; Vonderhaar, B.K. Activation of vascular endothelial growth factor (VEGF) by the ER-a variant, ERA3. Breast Cancer Res. Treat. 2006, 95, 37-43.
12. Bollig, A.; Miksicek, R.J. An estrogen receptor-a splicing variant mediates both positive and negative effects on gene transcription. Mol. Endocrinol. 2000, 14, 634-649.
13. Leung, Y.-K.; Mak, P.; Hassan, S.; Ho, S.-M. Estrogen receptor (ER)-p isoforms: a key to understanding ER-p signalling. Proc. Natl. Acad. Sci. USA 2006, 103, 13162-13167.
14. Girault, I.; Andrieu, C; Tozlu, S.; Spyratos, F.; Bièche, I.; Lidereau, R. Altered expression pattern of alternatively spliced estrogen receptor p transcripts in breast carcinoma. Cancer Lett. 2004, 215, 101-112.
15. Poola, I.; Abraham, J.; Baldwin, K.; Saunders, A.; Bhatnagar, R. Estrogen receptors beta4 and beta5 are full length functionally distinct ERp isoforms. Endocrine 2005, 27, 227-238.
16. Rey, J.M.; Pujol, P.; Dechaud, H.; Edouard, E.; Hedon, B.; Maudelonde, T. Expression of oestrogen receptor-a splicing variants and oestrogen receptor-p in endometrium of infertile patients. Mol. Hum. Reprod. 1998, 4, 641-647.
17. Marshburn, P.B.; Zhang, J.; Bahrani-Mostafavi, Z.; Mostafavi, B.Z.; Marroum, M.-C; Mougeot, J.-L.C; Roshon, M.J. Estrogen receptor-a messenger RNA variants that lack exon 5 or exon 7 are coexpressed with wild-type form in human endometrium during all phases of the menstrual cycle. Am. J. Obstet Gynecol. 2004, 191, 626-633.
18. Skrzypczak, M.; Bieche, I.; Szymczak, S.; Tozlu, S.; LewanDdowowski, S.; Girault, I.; Radwanska, K.; Szczylik, C; Jakowicki, J.; LidereauI, R.; Kaczmarek, L. Evaluation of mRNA expression of estrogen receptor p and its isoforms in human normal and neoplastic endometrium. Int. J. Cancer 2004, 110, 783-787.
19. Leung, Y.-K.; Lam, H.-M.; Wu, S.; Song, D.; Levin, L.; Cheng, L.; Wu, C.-L.; Ho, S.-M. Estrogen receptor p2 and p5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion. Endocr. Relat. Cancer 2010, 17, 675-689.
20. Singh, M.N.; Stringfellow, H.F.; Taylor, S.E.; Ashton, K.M.; Ahmad, M.; Abdo, K.R.; El-Agnaf, O.M.A.; Martin-Hirsch, P.L.; Martin, F.L. Elevated expression of CYP1A1 and y-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium. Mol. Hum. Reprod. 2008, 14, 655-663.
21. Singh, P.B.; Ragavan, N.; Ashton, K.M.; Basu, P.; Nadeem, S.M.; Nicholson, CM.; Krishna, R.K.G; Matanhelia, S.S.; Martin, F.L. Quantified gene expression levels for phase I/II metabolizing enzyme and estrogen receptor levels in benign prostate from cohorts designated as high-risk (UK) versus low-risk (India) for adenocarcinoma at this organ site: a preliminary study. Asian J. Androl. 2010, 12, 203-214.