Elevated expression of CYP1A1 and γ-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium

Molecular Human Reproduction

Volumn 14, Issue 11, 2008, Pages 655-663

  Singh, Maneesh N ^a,b   Stringfellow, Helen F ^a   Taylor, Siân E ^a,b   Ashton, Kate M ^a   Ahmad, Mushfika ^c   Abdo, Khalil R ^a   El Agnaf, Omar M A ^c   Martin Hirsch, Pierre L ^a,b   Martin, Francis L ^b  

^a LANCASHIRE TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b LANCASTER UNIVERSITY   (United Kingdom)

^c UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

synuclein; BCL 2; CYP1A1; Endometriosis; Estrogen receptor

Indexed keywords

BETA ACTIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DIOXIN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GAMMA SYNUCLEIN; PROTEIN BCL 2;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ECTOPIC ORGAN; ENDOMETRIOSIS; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TISSUE DISTRIBUTION; UPREGULATION;

ADULT; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; ENDOMETRIOSIS; ENDOMETRIUM; FEMALE; GAMMA-SYNUCLEIN; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 57649230819     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gan056     Document Type: Article

References (46)

1. Abou-Setta AM, Al-Inany HG, Farquhar CM. Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery. Cochrane Database Syst Rev 2006;18:CD005072.
2. Ahmad M, Attoub S, Singh MN, Martin FL, El-Agnaf OMA. γ-Synuclein and the progression of cancer. FASEB J 2007;21:3419-3430; doi: 10.1096/fj.07-8379rev.
3. Beckman EN, Pintado SO, Leonard GL, Sternberg WH. Endometriosis of the prostate. Am J Surg Pathol 1985;9:374-379.
4. Barber JL, Walsh MJ, Hewitt R, Jones KC, Martin FL. Low-dose treatment with polybrominated diphenyl ethers (PBDEs) induce altered characteristics in MCF-7 cells. Mutagenesis 2006;21:351-360; doi: 10.1093/mutage/ge1038.
5. Bofinger DP, Feng L, Chi L-H, Love J, Stephen FD, Sutter TR, Osteen KG, Costich TG, Batt RE, Koury ST et al. Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explants cultures of human endometrium. Toxicol Sci 2001;62:299-314.
6. Braun DP, Ding J, Shaheen F, Willey JC, Rana N, Dmowski WP. Quantitative expression of apoptosis-regulating genes in endometrium from women with and without endometriosis. Fertil Steril 2007;87:263-268.
7. Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin AK. Synucleins are expressed in the majority of breast and ovarian carcinomas and preneoplastic lesions of the ovary. Cancer 2000; 88:2154-2163.
8. Bulun SE, Zeitoun KM, Kilic G. Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues. Am J Obstet Gynecol 2000;182 767-775.
9. Donnez J, Van Langendonckt A, Casanas-Roux F, Van Gossum JP, Pirard C, Jadoul P, Squifflet J, Smets M. Current thinking on the pathogenesis of endometriosis. Gynecol Obstet Invest 2002;54:52-58.
10. Donnez J, Pirard C, Smets M, Jadoul P, Squifflet J. Surgical management of endometriosis. Best Pract Res Clin Obstet Gynaecol 2004;18 329-348.
11. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am 1997;24:235-258.
12. Fierens S, Mairesse H, Heilier JF, De Burbure C, Focant JF, Eppe G, De Pauw E, Bernard A. Dioxin/polychlorinated biphenyl body burden, diabetes and endometriosis: Findings in a population-based study in Belgium. Biomarkers 2003;8:529-534.
13. Guo SW. The link between exposure to dioxin and endometriosis: A critical appraisal of primate data. Gynecol Obstet Invest 2004; 57:157-173.
14. Heilier JF, Nackers F, Verougstraete V, Tonglet R, Lison D, Donnez J. Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic (adenomyotic) nodules. Fertil Steril 2005;84:305-312.
15. Hockenbery D, Nuñez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-336.
16. Jiang Y, Liu YE, Lu A, Gupta A, Goldberg ID, Liu J, Shi YE. Stimulation of estrogen receptor signaling by g synuclein. Cancer Res 2003; 63:3899-3903.
17. Jiao H, Allinson SL, Walsh MJ, Hewitt R, Cole KJ, Phillips DH, Martin FL. Growth kinetics in MCF-7 cells modulate benzo [a] pyrene-induced CYP1A1 up-regulation. Mutagenesis 2007;22:111-116; doi: 10.1093/mutage/gel060.
18. Jones RK, Bulmer JN, Searle RF. Phenotypic and functional studies of leukocytes in human endometrium and endometriosis. Hum Reprod Update 1998;4:702-709.
19. Jubanyik KJ, Comite F. Extrapelvic endometriosis. Obstet Gynecol Clin North Am 1997;24:411-440.
20. Kalantzi OI, Hewitt R, Ford KJ, Cooper L, Alcock RE, Thomas GO, Morris JA, McMillan TJ, Jones KC, Martin FL. Low-dose induction of micronuclei by lindane. Carcinogenesis 2004;25:613-622; doi: 10.1093/ carcin/bgh048.
21. Kennedy S. The genetics of endometriosis. J Reprod Med 1998;43 263-268.
22. Lavedan C, Leroy E, Dehejia A, Buchholtz S, Dutra A, Nussbaum RL, Polymeropoulos MH. Identification, localization and characterisation of the human γ-synuclein gene. Hum Genet 1998;103:106-112.
23. Matthews J, Gustafsson JA. Estrogen receptor and aryl hydrocarbon receptor signalling pathways. Nucl Recept Signal 2006;4:e016.
24. Matthews J, Wihlen B, Thomsen J, Gustaffson JA. Aryl hydrocarbon receptor-mediated transcription: Ligand-dependent recruitment of estrogen receptor α to 2,3,7,8-tetrachlorodibenzo-p dioxin-responsive promoters. Mol Cell Biol 2005;25 5317-5328.
25. Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Malspeis S, Willett WV, Hunter DJ. Reproductive history and endometliosis among premenopausal women. Obstet Gynecol 2004;104:965-974.
26. Nisolle M, Casanas-Roux F, Anaf V, Mine JM, Donnez J. Morphometric study of the stromal vascularisation in peritoneal endometriosis. Fertil Steril 1993;59:681-684.
27. Ninkina NN, Alimova-Kost MV, Paterson JW, Delaney L, Cohen BB, Inueh S, Gnuchev NV, Davies AM, Buschman VL. Organization, expression and polymorphism of the human persyn gene. Hum Mol Genet 1998;7: 1417-1424.
28. Oral E, Arici A. Pathogenesis of endometriosis. Obstet Gynecol Clin North Am 1997;24:219-233.
29. Pauwels A, Schepens PJ, D'Houghe T, Delbeke L, Dhont M, Brouwer A, Weyler J. The risk of endometriosis and exposare to dioxins and polychlorinated-biphenyls: A case control study of infertile women. Hum Reprod 2001, 16: 2050-2055.
30. Porpora MG, Ingelido AM, di Domenico A, Ferro A, Crobu M, Pallante D, Cardelli M, Cosmi EV, De Felip E. Increased levels of polychlorobiphenyls in Italian women with endometriosis. Chemosphere 2006;63:1361-1367.
31. Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility. Fertil Steril 2006;86 S156-S160.
32. Prowse AH, Manek S, Varma R, Liu J, Godwin AK, Maher ER, Tomlinson IP, Kennedy SH. Molecular genetic evidence that endometriosis is a precursor of ovarian cancer. Int J Cancer 2006;119:556-562.
33. Ragavan N, Hewitt R, Cooper LJ, Ashton KM, Hindley AC, Nicholson CM, Fullwood NJ, Matanhelia SS, Martin FL. CYP1B1 expression in prostate is higher in the peripheral than in the transition zone. Cancer Lett 2004;215:69-78; doi: 10.1016/j.canlet.2004.06.051.
34. Rier S, Foster WG. Environmental dioxins and endometriosis. Semin Reprod Med 2003;21:145-154.
35. Rier SE, Martin DC, Bowman RE, Dmowski WP, Becker JL. Endometriosus in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol 1993;21: 433-441.
36. Sampson JA. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 1927; 14:422-469.
37. Schrodt GR, Alcorn MO, Ibanez J. Endometriosis of the male urinary system: A case report. J Urol 1980;124:722-723.
38. Schrenk D. Impact of dioxin-type induction of drug-metabolizing enzymes on the metabolism of eado- and xenobiotics. Biochem Pharmacol 1998;55:1155-1162.
39. Shimada T, Gillam EM, Sutter TR, Strickland PT, Guengerich FP, Yamazaki H. Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. Drug Metab Dispos 1997;25:617-622.
40. Singh VK, Zhou, Y, Marsh JA, Uversky VN, Forman-Kay JD, Liu J, Jia Z. Synuclein-γ targeting peptide inhibitor that enhances sensitivity of breast cancer cells to antimicrotubule drugs. Cancer Res 2007b; 67:626-633.
41. Singh MN, Stringfellow HF, Paraskevaidis E, Martin-Hirsch PL, Martin FL. Tamoxifen: Important considerations of a multi-functional compound with organ-specific properties. Cancer Treat Rev 2007a;33:91-100; doi: 10.1016/j.ctrv.2006.09.008.
42. Singh PB, Matanhelia SS, Martin FL. A potential paradox in prostate adenocarcinoma progression: Estrogen as the initiating agent. Eur J Cancer 2008;44:928-936; doi: 10.1016/j.ejca.2008.02.051.
43. Surguccheva IG, Sivak JM, Fini ME, Palazzo RE, Surguchov AP. Effect of -γ-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys 2003;410 167-176.
44. Whitlock JP, Chichester CH, Bedgood RM, Okino ST, Ko HP, Ma Q, Dong L, Li H, Clarke-Katzenberg R. Induction of drug-metabolizing enzymes by dioxin. Drug Metab Rev 1997;29;1107 -1127.
45. Witz CA. Pathogenesis of endometriosis. Gynecol Obstet Invest 2002;53: 52-62.
46. Yared E, McMillan TJ, Martin FL. Genotoxic effects of estrogens in breast cells as detected by the micronucleus assay and the Comet assay. Mutagenesis 2002;17:345-352.