Prolonging survival in patients with cirrhosis: Old drugs with new indications

Gastroenterology

Volumn 139, Issue 6, 2010, Pages

  Tsochatzis, Emmanuel A ^a   Bosch, Jaime ^b   Burroughs, Andrew K ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; COTRIMOXAZOLE; ENOXAPARIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOSORBIDE MONONITRATE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NADOLOL; NORFLOXACIN; PRAZOSIN; PROPRANOLOL; QUINOLONE DERIVATIVE; RIFAXIMIN; SIMVASTATIN; WARFARIN;

ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ANTICOAGULANT THERAPY; BACTEREMIA; BACTERIAL INFECTION; BACTERIAL PERITONITIS; BLEEDING; CLINICAL TRIAL; DISEASE MARKER; DISEASE SEVERITY; DRUG COST; DRUG INDICATION; EDITORIAL; HEPATIC ENCEPHALOPATHY; HEPATIC VENOUS PRESSURE GRADIENT; HEPATORENAL SYNDROME; HUMAN; INFECTION RISK; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER TOXICITY; MORBIDITY; MORTALITY; OVERALL SURVIVAL; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PORTAL VEIN THROMBOSIS; PRESSURE GRADIENT; PRIORITY JOURNAL; PROGNOSIS; SPLANCHNIC BLOOD FLOW; SPONTANEOUS BACTERIAL PERITONITIS; THROMBOSIS PREVENTION; VASODILATATION;

EID: 78649690871     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.10.031     Document Type: Editorial

References (34)

1. World Health Organization WHO European Health for All Database 2009 Author Geneva
2. Deaths: Preliminary data for 2007 National Vital Statistics Report 2009 58
3. G. D'Amico, G. Garcia-Tsao, and L. Pagliaro Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies J Hepatol 44 2006 217 231
4. G. Garcia-Tsao, and J. Bosch Management of varices and variceal hemorrhage in cirrhosis N Engl J Med 362 2010 823 832
5. C. Ripoll, R. Groszmann, and G. Garcia-Tsao Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis Gastroenterology 133 2007 481 488
6. R.J. Groszmann, G. Garcia-Tsao, and J. Bosch Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis N Engl J Med 353 2005 2254 2261
7. C.K. Triantos, V. Nikolopoulou, and A.K. Burroughs Review article: the therapeutic and prognostic benefit of portal pressure reduction in cirrhosis Aliment Pharmacol Ther 28 2008 943 952
8. C. Triantos, D. Samonakis, and U. Thalheimer The relationship between liver function and portal pressure: what comes first, the chicken or the egg? J Hepatol 42 2005 146 147
9. G.H. Lo, W.C. Chen, and C.K. Lin Improved survival in patients receiving medical therapy as compared with banding ligation for the prevention of esophageal variceal rebleeding Hepatology 48 2008 580 587
10. M. Senzolo, E. Cholongitas, and P. Burra beta-Blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis Liver Int 29 2009 1189 1193
11. M. Perez-Paramo, J. Munoz, and A. Albillos Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites Hepatology 31 2000 43 48
12. U. Thalheimer, J. Bosch, and A.K. Burroughs How to prevent varices from bleeding: shades of greythe case for nonselective beta blockers Gastroenterology 133 2007 2029 2036
13. J. Goulis, D. Patch, and A.K. Burroughs Bacterial infection in the pathogenesis of variceal bleeding Lancet 353 1999 139 142
14. M.C. Hou, H.C. Lin, and T.T. Liu Antibiotic prophylaxis after endoscopic therapy prevents rebleeding in acute variceal hemorrhage: a randomized trial Hepatology 39 2004 746 753
15. C.H. Jun, C.H. Park, and W.S. Lee Antibiotic prophylaxis using third generation cephalosporins can reduce the risk of early rebleeding in the first acute gastroesophageal variceal hemorrhage: a prospective randomized study J Korean Med Sci 21 2006 883 890
16. V. Arvaniti, G. D'Amico, and G. Fede Infections in cirrhosis increase mortality four-fold and should be used in determining prognosis Gastroenterology 139 2010 1246 1256
17. B.A. Runyon Management of adult patients with ascites due to cirrhosis: an update Hepatology 49 2009 2087 2107
18. J. Fernandez, M. Navasa, and R. Planas Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis Gastroenterology 133 2007 818 824
19. B. Rasaratnam, D. Kaye, and G. Jennings The effect of selective intestinal decontamination on the hyperdynamic circulatory state in cirrhosis A randomized trial Ann Intern Med 139 2003 186 193
20. N.M. Bass, K.D. Mullen, and A. Sanyal Rifaximin treatment in hepatic encephalopathy N Engl J Med 362 2010 1071 1081
21. J. Vlachogiannakos, A.S. Saveriadis, and N. Viazis Intestinal decontamination improves liver haemodynamics in patients with alcohol-related decompensated cirrhosis Aliment Pharmacol Ther 29 2009 992 999
22. S.M. Riordan, and R. Williams The intestinal flora and bacterial infection in cirrhosis J Hepatol 45 2006 744 757
23. J.G. Abraldes, A. Albillos, and R. Banares Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial Gastroenterology 136 2009 1651 1658
24. H.B. El-Serag, M.L. Johnson, and C. Hachem Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes Gastroenterology 136 2009 1601 1608
25. J.H. Lewis, M.E. Mortensen, and S. Zweig Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial Hepatology 46 2007 1453 1463
26. G.V. Papatheodoridis, N. Chrysanthos, and E. Cholongitas Thrombotic risk factors and liver histologic lesions in non-alcoholic fatty liver disease J Hepatol 51 2009 931 938
27. V. Calvaruso, S. Maimone, and A. Gatt Coagulation and fibrosis in chronic liver disease Gut 57 2008 1722 1727
28. I.R. Wanless, F. Wong, and L.M. Blendis Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension Hepatology 21 1995 1238 1247
29. A. Tripodi, F. Salerno, and V. Chantarangkul Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests Hepatology 41 2005 553 558
30. E.A. Tsochatzis, M. Senzolo, and G. Germani Systematic review: portal vein thrombosis in cirrhosis Aliment Pharmacol Ther 31 2010 366 374
31. R. Zecchini, A. Ferrari, and V. Bernabucci Anticoagulant therapy is safe and effective n preventing portal vein thrombosis (PVT) in advanced cirrhotic patients: a prospective randomized controlled study J Hepatol 52 2010 S460
32. J. Bosch, and G. Garcia-Tsao Pharmacological versus endoscopic therapy in the prevention of variceal hemorrhage: and the winner is Hepatology 50 2009 674 677
33. M. Mejias, E. Garcia-Pras, and C. Tiani Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats Hepatology 49 2009 1245 1256
34. British National Formulary BNF 2010 September 2009