Characterization of currently marketed heparin products: Reversed-phase ion-pairing liquid chromatography mass spectrometry of heparin digests

Analytical Chemistry

Volumn 82, Issue 23, 2010, Pages 9865-9870

  Brustkern, Adam M ^a   Buhse, Lucinda F ^a   Nasr, Moheb ^a   Al Hakim, Ali ^a   Keire, David A ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; CHONDROITIN SULFATES; COMPOSITION PROFILE; ENZYMATIC DIGESTIONS; EXTRACTED ION CHROMATOGRAM; GRADIENT ELUTION; HEXYLAMINE; ION TRAP MASS SPECTROMETER; ION-PAIRING; ION-PAIRING CHROMATOGRAPHY; ION-PAIRING REAGENT; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; RELATIVE ABUNDANCE; REVERSE PHASE; REVERSED PHASE; STANDARD SAMPLES; UNFRACTIONATED HEPARINS;

ACETONITRILE; CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; IONS; LIQUIDS; MASS SPECTROMETRY; POLYSACCHARIDES; SULFUR COMPOUNDS;

LIQUID CHROMATOGRAPHY;

CHONDROITIN SULFATE; DISACCHARIDE; HEPARIN; HEPARIN LYASE; HEPARITINSULFATE LYASE; POLYSACCHARIDE LYASE;

ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; METHODOLOGY; REVERSED PHASE LIQUID CHROMATOGRAPHY;

CHONDROITIN SULFATES; CHROMATOGRAPHY, REVERSE-PHASE; DISACCHARIDES; HEPARIN; HEPARIN LYASE; POLYSACCHARIDE-LYASES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 78649687391     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac102301j     Document Type: Article

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