Heparins from porcine and bovine intestinal mucosa: Are they similar drugs?

Thrombosis and Haemostasis

Volumn 103, Issue 5, 2010, Pages 1005-1015

  Aquino, Rafael S ^a   Pereira, Mariana S ^a   Vairo, Bruno C ^a   Cinelli, Leonardo P ^a   Santos, Gustavo R C ^a   Fonseca, Roberto J C ^a   Mourão, Paulo A S ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Glycosaminoglycans; Heparins; Serpins; Thrombosis; Venous thrombosis

Indexed keywords

BLOOD CLOTTING FACTOR 10A; DISACCHARIDASE; HEPARIN; DISACCHARIDE; PROTAMINE; PROTAMINE HEPARIN AGGREGATE; THROMBOPLASTIN;

ANTICOAGULATION; ARTICLE; BLEEDING; COW; INTESTINE MUCOSA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SWINE; ANIMAL; BLOOD; BLOOD CLOTTING; BOVINAE; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; HEMORRHAGE; ISOLATION AND PURIFICATION; METABOLISM; RAT; VENOUS THROMBOSIS; WISTAR RAT;

ANIMALS; BLOOD COAGULATION; CATTLE; DISACCHARIDES; FACTOR XA; HEMORRHAGE; HEPARIN; INTESTINAL MUCOSA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTAMINES; RATS; RATS, WISTAR; SWINE; THROMBOPLASTIN; VENOUS THROMBOSIS;

EID: 77952087071     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-11-0761     Document Type: Article

References (21)

1. Spyropoulos AC. Brave new world: The current and future use of novel anticoagulants. Thomb Res 2008; 123: S29-S35.
2. Ryckelynck JP, Chouraqui D, Lobbedez T, Anticoagulant of the extracorporeal circuit in chronic hemodialysis. Nephrologie 1998; 19: 223-225.
3. Liu H, Zhang Z, Linhardt RJ. Lessons learned from the contamination of heparin. Nat Prod Rep 2009; 26: 313-321.
4. Mulloy B, Gray E, Barrowcliffe TW. Characterization of unfractionated heparin: comparison of materials from the last 50 years. Thromb Haemost 2000; 84: 1052-1056. (Pubitemid 32014042)
5. Guerrini M, Naggi A, Guglieri S, et al. Complex glycosaminoglycans: profiling substitution patterns by two-dimensional nuclear magnetic resonance spectroscopy. Anal Biochem 2005; 337: 35-47. (Pubitemid 40092776)
6. Melo EI, Pereira MS, Cunha RS, et al. Heparin quality control in the Brazilian market: implications in the cardiovascular surgery. Rev Bras Cir Cardiovasc 2008; 23: 169-174.
7. ANVISA, alert about the increasing reports of bleedin and peri- or post-operative blood dyscrasias in Brazil possibly associated with the use of heparin from bovine instead of porcine intestine (24 oct 2008). Available at: http://www.anvisa.gov.br/farmacovigilancia/alerta/federal/2008/federal-3-08.htm.
8. Blossom DB, Kallen AJ, Patel PR, et al. Outbreak of adverse reactions associated with contaminated heparin. N Engl J Med 2008; 359: 2674-2684.
9. Castro MO, Pomin VH, Santos LL, et al. A unique 2-sulfated β-galactan from the egg jelly of the sea urchin Glyptocidaris crenularis: conformational flexibility versus induction of the sperm acrosome reaction. J Biol Chem 2009; 284: 18790-18800.
10. Farndale RW, Buttle DJ, Barret AJ. Improved quantitation and discrimination of sulfated glycosaminoglycans by use of dimethylmethylene blue. Biochem Biophys Acta 1986; 883: 173-177.
11. Mourão PA, Bastos, IG. Highly acidic glycans from sea cucumbers. Isolation and fractionation of fucose-rich sulfated polysaccharides from the body wall of Ludwigothurea grisea. Eur J Biochem 1987; 166: 639-645.
12. Herbert JM, Bernat A, Maffrand JP. Importance of platelets in experimental venous thrombosis in rats. Blood 1992; 80: 2281-2286.
13. Zancan P, Mourão PAS. Venous and arterial thrombosis in rat models: dissociation of the antithrombotic effects of glycosaminoglycans. Blood Coagul Fibrinolysis 2004; 15: 45-54. (Pubitemid 38534685)
14. Li W, Johnson DJ, Esmon CT, et al. Structure of the antithrombin- thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol 2004; 11: 857-862. (Pubitemid 39128802)
15. Zhang Z, Li B, Suwan J, et al. Analysis of pharmaceutical heparins and potential contaminations using 1H-NMR and PAGE. J Pharm Sci 2009; 99: 4017-4026.
16. Kusche M, Giangiacomo T, Casu B, et al. Biosynthesis of heparin. Availability of glucosaminyl 3-O-sulfation sites. J Biol Chem 1990; 265: 7292-7300. (Pubitemid 20162467)
17. US FARMACOPEIA. USP Heparin Information (June, 2009). Available at: http://www.usp.org/ hottopics/heparin.html.
18. Cavalcante MCM, Allodi S, Valente AP, et al. Occurrence of heparin in the invertebrate Styela plicata (Tunicata) is restricted to cell layers facing the outside environment. An ancient role in defense? J Biol Chem 2000; 275: 36189-36196.
19. 13C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives. Carb Res 1996; 194: 15-27.
20. 1H NMR experiments. Anal Chem 2001; 73: 2310-2316.
21. Guerrini M, Beccati D, Shriver Z, et al. Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events. Nat Biotechnol 2008; 26: 669-675. (Pubitemid 351824692)