VE-cadherin regulates philadelphia chromosome positive acute lymphoblastic leukemia sensitivity to apoptosis

Cancer Microenvironment

Volumn 3, Issue 1, 2010, Pages 67-81

  O'Leary, Heather ^a   Akers, Stephen M ^a   Piktel, Debra ^a   Walton, Cheryl ^a   Fortney, James E ^a   Martin, Karen H ^a   Craig, Michael ^a   Coad, James ^a   Gibson, Laura F ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bcr Abl; Bone marrow stromal cells; HIF 2 ; Philadelphia chromosome (Ph+); VE cadherin

Indexed keywords

ABELSON KINASE; DAUNORUBICIN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; IMATINIB; VASCULAR ENDOTHELIAL CADHERIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; APOPTOSIS; CELL SURVIVAL; CELL VIABILITY; CHILD; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; PHILADELPHIA CHROMOSOME POSITIVE CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SCHOOL CHILD; STROMA CELL;

EID: 78649654374     PISSN: 18752292     EISSN: 18752284     Source Type: Journal    
DOI: 10.1007/s12307-010-0035-6     Document Type: Conference Paper

References (58)

1. Carroll WL, Bhojwani D, Min DJ et al (2003) Pediatric acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program 102-131
2. R Pieters WL Carroll 2008 Biology and treatment of acute lymphoblastic leukemia Pediatr Clin North Am 55 1 20 10.1016/j.pcl.2007.11.002 18242313 ix (Pubitemid 351173191)
3. D Hoelzer 1993 Acute lymphoblastic leukemia-progress in children, less in adults N Engl J Med 329 1343 1344 1:STN:280:DyaK2c%2FhvFGksw%3D%3D 10.1056/NEJM199310283291810 8413416 (Pubitemid 23317336)
4. S Faderl HM Kantarjian DA Thomas, et al. 2000 Outcome of Philadelphia chromosome-positive adult acute lymphoblastic leukemia Leuk Lymphoma 36 263 273 1:STN:280:DC%2BD3c7jslelsQ%3D%3D 10.3109/10428190009148847 10674898
5. JP Radich 2001 Philadelphia chromosome-positive acute lymphocytic leukemia Hematol Oncol Clin North Am 15 21 36 1:STN:280:DC%2BD3MzmvVGguw%3D%3D 10.1016/S0889-8588(05)70198-2 11258387 (Pubitemid 32201866)
6. LC Bailey BJ Lange SR Rheingold NJ Bunin 2008 Bone-marrow relapse in paediatric acute lymphoblastic leukaemia Lancet Oncol 9 873 883 10.1016/S1470-2045(08)70229-8 18760243
7. CH Pui SC Howard 2008 Current management and challenges of malignant disease in the CNS in paediatric leukaemia Lancet Oncol 9 257 268 10.1016/S1470-2045(08)70070-6 18308251 (Pubitemid 351722945)
8. S Li D Li 2007 Stem cell and kinase activity-independent pathway in resistance of leukaemia to BCR-ABL kinase inhibitors J Cell Mol Med 11 1251 1262 1:CAS:528:DC%2BD1cXis1Wgsb0%3D 10.1111/j.1582-4934.2007.00108.x 18205699
9. D Jones D Thomas CC Yin, et al. 2008 Kinase domain point mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia emerge after therapy with BCR-ABL kinase inhibitors Cancer 113 985 994 1:CAS:528: DC%2BD1cXhtFSlurrM 10.1002/cncr.23666 18615627
10. MB Meads LA Hazlehurst WS Dalton 2008 The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance Clin Cancer Res 14 2519 2526 1:CAS:528:DC%2BD1cXlsV2qs74%3D 10.1158/1078-0432.CCR-07-2223 18451212
11. RE Mudry JE Fortney T York BM Hall LF Gibson 2000 Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy Blood 96 1926 1932 1:CAS:528:DC%2BD3cXmt1Omu7o%3D 10961896
12. L Wang JE Fortney LF Gibson 2004 Stromal cell protection of B-lineage acute lymphoblastic leukemic cells during chemotherapy requires active Akt Leuk Res 28 733 742 10.1016/j.leukres.2003.10.033 15158095 (Pubitemid 38639741)
13. BM Hall JE Fortney L Taylor, et al. 2004 Stromal cells expressing elevated VCAM-1 enhance survival of B lineage tumor cells Cancer Lett 207 229 239 1:CAS:528:DC%2BD2cXjtV2ns74%3D 10.1016/j.canlet.2003.10.033 15072833 (Pubitemid 38457045)
14. T Sethi RC Rintoul SM Moore, et al. 1999 Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo Nat Med 5 662 668 1:CAS:528:DyaK1MXjs1Kls7o%3D 10.1038/9511 10371505 (Pubitemid 29289430)
15. LA Hazlehurst JS Damiano I Buyuksal WJ Pledger WS Dalton 2000 Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR) Oncogene 19 4319 4327 1:CAS:528:DC%2BD3cXmvVyqs78%3D 10.1038/sj.onc.1203782 10980607
16. F Aoudjit K Vuori 2001 Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells Oncogene 20 4995 5004 1:CAS:528: DC%2BD3MXmtlCks74%3D 10.1038/sj.onc.1204554 11526484 (Pubitemid 32769789)
17. KH Shain DN Yarde MB Meads, et al. 2009 Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation Cancer Res 69 1009 1015 1:CAS:528:DC%2BD1MXhtFOltLc%3D 10.1158/0008-5472.CAN-08-2419 19155309
18. S Iwamoto K Mihara JR Downing CH Pui D Campana 2007 Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase J Clin Invest 117 1049 1057 1:CAS:528:DC%2BD2sXktVOit78%3D 10.1172/JCI30235 17380207 (Pubitemid 46556761)
19. H Nishigaki C Ito A Manabe, et al. 1997 Prevalence and growth characteristics of malignant stem cells in B-lineage acute lymphoblastic leukemia Blood 89 3735 3744 1:CAS:528:DyaK2sXjt12qtbY%3D 9160679
20. L Wang H O'Leary J Fortney LF Gibson 2007 Ph+/VE-cadherin+ identifies a stem cell like population of acute lymphoblastic leukemia sustained by bone marrow niche cells Blood 110 3334 3344 1:CAS:528:DC%2BD2sXht1yqurrO 10.1182/blood-2007-01-068122 17638851 (Pubitemid 350106327)
21. MJ Hendrix EA Seftor AR Hess RE Seftor 2003 Molecular plasticity of human melanoma cells Oncogene 22 3070 3075 1:CAS:528:DC%2BD3sXkt12qtbY%3D 10.1038/sj.onc.1206447 12789282 (Pubitemid 36713757)
22. DW van der Schaft F Hillen P Pauwels, et al. 2005 Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia Cancer Res 65 11520 11528 10.1158/0008-5472.CAN-05-2468 16357161 (Pubitemid 41821710)
23. MA Maynard M Ohh 2007 The role of hypoxia-inducible factors in cancer Cell Mol Life Sci 64 2170 2180 1:CAS:528:DC%2BD2sXhtVaisb%2FJ 10.1007/s00018-007-7082-2 17514355 (Pubitemid 350103108)
24. N Akeno J Robins M Zhang MF Czyzyk-Krzeska TL Clemens 2002 Induction of vascular endothelial growth factor by IGF-I in osteoblast-like cells is mediated by the PI3K signaling pathway through the hypoxia-inducible factor-2alpha Endocrinology 143 420 425 1:CAS:528:DC%2BD38XosFWktg%3D%3D 10.1210/en.143.2.420 11796494 (Pubitemid 34107194)
25. PW Conrad TL Freeman D Beitner-Johnson DE Millhorn 1999 EPAS1 trans-activation during hypoxia requires p42/p44 MAPK J Biol Chem 274 33709 33713 1:CAS:528:DyaK1MXns1ejsbY%3D 10.1074/jbc.274.47.33709 10559262
26. G Qing MC Simon 2009 Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes Curr Opin Genet Dev 19 60 66 1:CAS:528:DC%2BD1MXisFKns7g%3D 10.1016/j.gde.2008.12.001 19167211
27. A Le Bras F Lionneton V Mattot, et al. 2007 HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites Oncogene 26 7480 7489 10.1038/sj.onc.1210566 17563748 (Pubitemid 350158718)
28. J Ben-Shoshan S Schwartz G Luboshits, et al. 2008 Constitutive expression of HIF-1alpha and HIF-2alpha in bone marrow stromal cells differentially promotes their proangiogenic properties Stem Cells 26 2634 2643 1:CAS:528:DC%2BD1cXhtlyku7vI 10.1634/stemcells.2008-0369 18687993
29. A Jones C Fujiyama C Blanche, et al. 2001 Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines Clin Cancer Res 7 1263 1272 1:CAS:528: DC%2BD3MXktlelsrw%3D 11350893
30. L Holmquist-Mengelbier E Fredlund T Lofstedt, et al. 2006 Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype Cancer Cell 10 413 423 1:CAS:528:DC%2BD28Xht1Glu7nE 10.1016/j.ccr.2006.08.026 17097563 (Pubitemid 44693470)
31. RR Raval KW Lau MG Tran, et al. 2005 Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma Mol Cell Biol 25 5675 5686 1:CAS:528:DC%2BD2MXlslCjt7Y%3D 10.1128/MCB.25.13.5675-5686.2005 15964822 (Pubitemid 40853601)
32. JC Burns T Friedmann W Driever M Burrascano JK Yee 1993 Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells Proc Natl Acad Sci USA 90 8033 8037 1:CAS:528:DyaK3sXlslCqtbk%3D 10.1073/pnas.90.17.8033 8396259
33. MJ Hendrix EA Seftor PS Meltzer LM Gardner AR Hess DA Kirschmann GC Schatteman RE Seftor 2001 Expression and functional significance of VE-cadherin in aggressive human melanoma cells: role in vasculogenic mimicry Proc Natl Acad Sci USA 98 8018 8023 1:CAS:528:DC%2BD3MXlt1Kntbs%3D 10.1073/pnas.131209798 11416160 (Pubitemid 32642679)
34. ME Smith JI Brown C Fisher 1998 Epithelioid sarcoma: presence of vascular-endothelial cadherin and lack of epithelial cadherin Histopathology 33 425 431 1:STN:280:DyaK1M%2Fls1Gntw%3D%3D 10.1046/j.1365-2559.1998.00544.x 9839166 (Pubitemid 28529776)
35. M Labelle HJ Schnittler DE Aust, et al. 2008 Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling Cancer Res 68 1388 1397 1:CAS:528:DC%2BD1cXislaguro%3D 10.1158/0008-5472.CAN-07-2706 18316602 (Pubitemid 351346846)
36. T Vrekoussis EN Stathopoulos U De Giorgi, et al. 2006 Modulation of vascular endothelium by imatinib: a study on the EA.hy 926 endothelial cell line J Chemother 18 56 65 1:CAS:528:DC%2BD28XjtlGnu7c%3D 16572895
37. A Atfi L Abecassis MF Bourgeade 2005 Bcr-Abl activates the AKT/Fox O3 signalling pathway to restrict transforming growth factor-beta-mediated cytostatic signals EMBO Rep 6 985 991 1:CAS:528:DC%2BD2MXhtV2gsb3F 10.1038/sj.embor.7400501 16113647 (Pubitemid 41521956)
38. D Cortez G Reuther AM Pendergast 1997 The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells Oncogene 15 2333 2342 1:CAS:528:DyaK2sXnsFajsbs%3D 10.1038/sj.onc.1201400 9393877
39. Y Tabe L Jin Y Tsutsumi-Ishii, et al. 2007 Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells Cancer Res 67 684 694 1:CAS:528: DC%2BD2sXmtVKrtw%3D%3D 10.1158/0008-5472.CAN-06-3166 17234779 (Pubitemid 46192208)
40. AM Coluccia A Vacca M Dunach, et al. 2007 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation EMBO J 26 1456 1466 1:CAS:528:DC%2BD2sXisVKrurc%3D 10.1038/sj.emboj.7601485 17318191 (Pubitemid 46398694)
41. I Kim OH Yilmaz SJ Morrison 2005 CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells Blood 106 903 905 1:CAS:528:DC%2BD2MXntVSnurg%3D 10.1182/blood-2004-12-4960 15831702 (Pubitemid 41076431)
42. H Koga S Sugiyama K Kugiyama, et al. 2005 Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease J Am Coll Cardiol 45 1622 1630 1:CAS:528:DC%2BD2MXktVOjtr0%3D 10.1016/j.jacc.2005.02.047 15893178 (Pubitemid 40704497)
43. MJ Hendrix EA Seftor AR Hess RE Seftor 2003 Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma Nat Rev Cancer 3 411 421 1:CAS:528:DC%2BD3sXktFOnsb4%3D 10.1038/nrc1092 12778131 (Pubitemid 37328845)
44. EA Seftor PS Meltzer GC Schatteman, et al. 2002 Expression of multiple molecular phenotypes by aggressive melanoma tumor cells: role in vasculogenic mimicry Crit Rev Oncol Hematol 44 17 27 10.1016/S1040-8428(01)00199-8 12398997 (Pubitemid 35175468)
45. Y Zhou SJ Fisher M Janatpour, et al. 1997 Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion? J Clin Invest 99 2139 2151 1:CAS:528:DyaK2sXjtFCisbg%3D 10.1172/JCI119387 9151786
46. BS Parker P Argani BP Cook, et al. 2004 Alterations in vascular gene expression in invasive breast carcinoma Cancer Res 64 7857 7866 1:CAS:528:DC%2BD2cXptFelsr8%3D 10.1158/0008-5472.CAN-04-1976 15520192 (Pubitemid 39446919)
47. SC Shih GS Robinson CA Perruzzi, et al. 2002 Molecular profiling of angiogenesis markers Am J Pathol 161 35 41 1:CAS:528:DC%2BD38Xlsl2lu7k%3D 12107087
48. S Weis J Cui L Barnes D Cheresh 2004 Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis J Cell Biol 167 223 229 1:CAS:528:DC%2BD2cXptVKqt7c%3D 10.1083/jcb.200408130 15504909 (Pubitemid 39435066)
49. EB Voura M Sandig CH Siu 1998 Cell-cell interactions during transendothelial migration of tumor cells Microsc Res Tech 43 265 275 1:CAS:528:DyaK1cXotFGkurk%3D 10.1002/(SICI)1097-0029(19981101)43:3<265::AID- JEMT9>3.0.CO;2-Z 9840805 (Pubitemid 28524650)
50. N Rudini A Felici C Giampietro, et al. 2008 VE-cadherin is a critical endothelial regulator of TGF-beta signalling EMBO J 27 993 1004 1:CAS:528:DC%2BD1cXksVagtb0%3D 10.1038/emboj.2008.46 18337748 (Pubitemid 351508155)
51. T Lofstedt E Fredlund L Holmquist-Mengelbier, et al. 2007 Hypoxia inducible factor-2alpha in cancer Cell Cycle 6 919 926 17404509
52. KL Covello J Kehler H Yu, et al. 2006 HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth Genes Dev 20 557 570 1:CAS:528:DC%2BD28Xit1Kmtb0%3D 10.1101/gad.1399906 16510872 (Pubitemid 43345322)
53. K Parmar P Mauch JA Vergilio R Sackstein JD Down 2007 Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia Proc Natl Acad Sci USA 104 5431 5436 1:CAS:528:DC%2BD2sXkt1emtrY%3D 10.1073/pnas.0701152104 17374716 (Pubitemid 47175697)
54. CJ Hu A Sataur L Wang H Chen MC Simon 2007 The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha Mol Biol Cell 18 4528 4542 1:CAS:528:DC%2BD2sXht12js7vI 10.1091/mbc.E06-05-0419 17804822 (Pubitemid 350060179)
55. L Vincent P Kermani LM Young, et al. 2005 Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling J Clin Invest 115 2992 3006 1:CAS:528:DC%2BD2MXhtF2kt73M 10.1172/JCI24586 16224539 (Pubitemid 41567565)
56. I Petit MA Karajannis L Vincent, et al. 2008 The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death Blood 111 1951 1961 1:CAS:528:DC%2BD1cXisVeis7c%3D 10.1182/blood-2007-05-089219 18024794 (Pubitemid 351451505)
57. Y Hu Y Chen L Douglas S Li 2009 Beta-catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia Leukemia 23 109 116 1:CAS:528:DC%2BD1MXkvVaquw%3D%3D 10.1038/leu.2008.262 18818703
58. AE Abrahamsson I Geron J Gotlib, et al. 2009 Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation Proc Natl Acad Sci USA 106 3925 3929 1:CAS:528:DC%2BD1MXjt1Gktr0%3D 10.1073/pnas.0900189106 19237556