Effects of discontinuing benzodiazepine-derivative hypnotics on postural sway and cognitive functions in the elderly

International Journal of Geriatric Psychiatry

Volumn 25, Issue 12, 2010, Pages 1259-1265

  Tsunoda, Kenichi ^a   Uchida, Hiroyuki ^a,b,c   Suzuki, Takefumi ^b,c,d   Watanabe, Koichiro ^b   Yamashima, Tetsumori ^e   Kashima, Haruo ^b  

^a Minamihanno Hospital   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

benzodiazepine; cognitive function; elderly; hypnotic; postural sway; side effect

Indexed keywords

BENZODIAZEPINE DERIVATIVE; BROTIZOLAM; DIAZEPAM; ESTAZOLAM; ETIZOLAM; FLUNITRAZEPAM; FLURAZEPAM; HYPNOTIC AGENT; NITRAZEPAM; QUAZEPAM;

AGED; ARTICLE; ATTENTION; BIPOLAR DISORDER; BODY EQUILIBRIUM; CLINICAL ARTICLE; CLINICAL STABILOMETRIC PLATFORM; COGNITION; CRITICAL FLICKER FUSION TEST; DEMENTIA; DEMOGRAPHY; DRUG WITHDRAWAL; FALL RISK; FEMALE; HUMAN; INSOMNIA; LANGUAGE; LEEDS SLEEP EVALUATION QUESTIONNAIRE; MALE; MEMORY; NURSING HOME PATIENT; POSTURAL SWAY; PSYCHIATRIC DIAGNOSIS; PSYCHOMETRY; QUESTIONNAIRE; REPEATABLE BATTERY FOR THE ASSESSMENT OF NEUROPSYCHOLOGICAL STATUS; SCHIZOPHRENIA; SLEEP;

AGED; AGED, 80 AND OVER; COGNITION; FEMALE; FLICKER FUSION; FLURAZEPAM; GERIATRIC ASSESSMENT; HUMANS; HYPNOTICS AND SEDATIVES; MALE; NEUROPSYCHOLOGICAL TESTS; POSTURAL BALANCE; QUESTIONNAIRES; SLEEP;

EID: 78649652813     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2465     Document Type: Article

References (36)

1. American Psychiatric Association. 1994. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Publishing, Inc.: Arlington, VA.
2. Balestrieri M, Marcon G, Samani F, et al., 2005. Mental disorders associated with benzodiazepine use among older primary care attenders-a regional survey. Soc Psychiatry Psychiatr Epidemiol 40: 308-315.
3. Benitez CI, Smith K, Vasile RG, et al., 2008. Use of benzodiazepines and selective serotonin reuptake inhibitors in middle-aged and older adults with anxiety disorders: a longitudinal and prospective study. Am J Geriatr Psychiatry 16: 5-13.
4. Caserta MT, Bannon Y, Fernandez F, et al., 2009. Normal brain aging clinical, immunological, neuropsychological, and neuroimaging features. Int Rev Neurobiol 84: 1-19.
5. Cheng JS, Huang WF, Lin KM, Shih YT,. 2008. Characteristics associated with benzodiazepine usage in elderly outpatients in Taiwan. Int J Geriatr Psychiatry 23: 618-624.
6. Cook JM, Biyanova T, Thompson R, Coyne JC,. 2007a. Older primary care patients' willingness to consider discontinuation of chronic benzodiazepines. Gen Hosp Psychiatry 29: 396-401.
7. Cook JM, Marshall R, Masci C, Coyne JC,. 2007b. Physicians' perspectives on prescribing benzodiazepines for older adults: a qualitative study. J Gen Intern Med 22: 303-307.
8. Damestoy N, Collin J, Lalande R,. 1999. Prescribing psychotropic medication for elderly patients: some physicians' perspectives. CMAJ 161: 143-145.
9. Erman MK,. 2005. Therapeutic options in the treatment of insomnia. J Clin Psychiatry 66 (Suppl 9): 18-23.
10. Fernie GR, Gryfe CI, Holliday PJ, Llewellyn A,. 1982. The relationship of postural sway in standing to the incidence of falls in geriatric subjects. Age Ageing 11: 11-16.
11. Fick DM, Cooper JW, Wade WE, et al., 2003. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med 163: 2716-2724.
12. Folstein MF, Folstein SE, McHugh PR,. 1975. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-198.
13. Furukawa TA, Streiner DL, Young LT,. 2001. Is antidepressant- benzodiazepine combination therapy clinically more useful? A meta-analytic study. J Affect Disord 65: 173-177.
14. Haentjens P, Lamraski G, Boonen S,. 2005. Costs and consequences of hip fracture occurrence in old age: an economic perspective. Disabil Rehabil 27: 1129-1141.
15. Inagaki A, Inada T, Fujii Y,. 1999. Dose Equivalents of Psychotropic Drugs. Seiwa Press: Tokyo. [Not available in English].
16. Ioannidis G, Papaioannou A, Hopman WM, et al., 2009. Relation between fractures and mortality: results from the Canadian Muticentre Osteoporosis Study. CAMJ [e-pub ahead of print].
17. Kirby M, Denihan A, Bruce I, et al., 1999. Benzodiazepine use among the elderly in the community. Int J Geriatr Psychiatry 14: 280-284.
18. Leipzig RM, Cumming RG, Tinetti ME,. 1999. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatri Soc 47: 30-39.
19. Leufkens TR, Vermeeren A, Smink BE, van Ruitenbeek P, Ramaekers JG,. 2007. Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg. Psychopharmacology (Berl) 191: 951-959.
20. Maki BE, Holliday PJ, Topper AK,. 1994. A prospective study of postural balance and risk of falling in an ambulatory and independent elderly population. J Gerontol 49: 72-84.
21. Nurmi-Luthje I, Kaukonen JP, Luthje P, et al., 2006. Use of benzodiazepines and benzodiazepine-related drugs among 223 patients with an acute hip fracture in Finland: comparison of benzodiazepine findings in medical records and laboratory assays. Drugs Aging 23: 27-37.
22. O'Brien CP,. 2005. Benzodiazepine use, abuse, and dependence. J Clin Psychiatry 66 (Suppl 2): 28-33.
23. Parrott AC, Hindmarch I,. 1980. The Leeds Sleep Evaluation Questionnaire in psychopharmacological investigations-a review. Psychopharmacology (Berl) 71: 173-179.
24. Randolph C, Tierney MC, Mohr E, Chase TN,. 1998. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol 20: 310-319.
25. Sawada N, Uchida H, Suzuki T, et al., 2009. Persistence and compliance to antidepressant treatment in patients with depression: a chart review. BMC Psychiatry 9: 38.
26. Simon GE, Ludman EJ,. 2006. Outcome of new benzodiazepine prescriptions to older adults in primary care. Gen Hosp Psychiatry 28: 374-378.
27. Theander E, Jarnlo GB, Ornstein E, Karlsson M,. 2004. Activities of daily living decrease similarly in hospital-treated patients with a hip fracture or a vertebral fracture: a one-year prospective study in 151 patients. Scand J Public Health 32: 356-360.
28. Uchida H, Kapur S, Mulsant BH, et al., 2009a. Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms. Am J Geriatr Psychiatry 17: 255-263.
29. Uchida H, Mamo DC, Mulsant BH, Pollock BG, Kapur S,. 2009b. Increased antipsychotic sensitivity in elderly patients: evidence and mechanisms. J Clin Psychiatry 70: 397-405.
30. Uchida H, Suzuki T, Mamo DC, et al., 2009c. Benzodiazepine and antidepressant use in elderly patients with anxiety disorders: a survey of 796 outpatients in Japan. J Anxiety Disord 23: 477-481.
31. Uchida H, Suzuki T, Mamo DC, et al., 2008. Effects of age and age of onset on prescribed antipsychotic dose in schizophrenia spectrum disorders: a survey of 1,418 patients in Japan. Am J Geriatr Psychiatry 16: 584-593.
32. Uchida H, Suzuki T, Mamo DC, et al., 2009d. Survey of benzodiazepine and antidepressant use in outpatients with mood disorders in Japan. Psychiatry Clin Neurosci 63: 244-246.
33. Valenstein M, Taylor KK, Austin K, et al., 2004. Benzodiazepine use among depressed patients treated in mental health settings. Am J Psychiatry 161: 654-661.
34. Veronese A, Garatti M, Cipriani A, Barbui C,. 2007. Benzodiazepine use in the real world of psychiatric practice: low-dose, long-term drug taking and low rates of treatment discontinuation. Eur J Clinl Pharmacol 63: 867-873.
35. Verster JC, Volkerts ER, Verbaten MN,. 2002. Effects of alprazolam on driving ability, memory functioning and psychomotor performance: a randomized, placebo-controlled study. Neuropsychopharmacology 27: 260-269.
36. Yamashima T, Yoshida M, Kumahashi K, et al., 2002. The Japanese version of RBANS (Repeatable Battery for the Assessment of Neuropsychological Status). No To Shinkei 54: 463-471. [Not available in English].