Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7 m-β- cyclodextrin or a co-solvent system

Biopharmaceutics and Drug Disposition

Volumn 31, Issue 8-9, 2010, Pages 450-454

  Koltun, Maria ^a   Morizzi, Julia ^a   Katneni, Kasiram ^a   Charman, Susan A ^a   Shackleford, David M ^a   McIntosh, Michelle P ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

cyclodextrins; intravenous; melphalan; pharmacokinetics; rodent

Indexed keywords

BETA CYCLODEXTRIN SULFOBUTYL ETHER; MELPHALAN; SOLVENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; MALE; NONHUMAN; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BETA-CYCLODEXTRINS; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; EXCIPIENTS; FREEZE DRYING; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; MELPHALAN; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SOLVENTS;

EID: 78649639286     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.725     Document Type: Article

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