Impact of chlorpromazine self-association on its apparent binding constants with cyclodextrins: Effect of SBE7-β-CD on the disposition of chlorpromazine in the rat

Journal of Pharmaceutical Sciences

Volumn 99, Issue 7, 2010, Pages 2999-3008

  McIntosh, Michelle P ^a   Leong, Nathania ^a   Katneni, Kasiram ^a   Morizzi, Julia ^a   Shackleford, David M ^a   Prankerd, Richard J ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Characterisation; Cyclodextrins; Formulation vehicle; Inclusion compounds; Micelle; Physical; Physicochemical properties; Preclinical pharmacokinetics; Renal excretion

Indexed keywords

CHLORPROMAZINE; CYCLODEXTRIN DERIVATIVE; SULFOBUTYLETHER CYCLODEXTRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BLOOD SAMPLING; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EXCRETION; DRUG URINE LEVEL; MALE; NONHUMAN; PH; RAT; SPECTROFLUOROMETRY; ULTRAVIOLET SPECTROPHOTOMETRY; URINALYSIS; URINARY EXCRETION;

EID: 77953317212     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22064     Document Type: Article

References (20)

1. Loftsson T, Brewster ME. 1996. Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. J Pharm Sci 85:1017-1025. (Pubitemid 26338912)
2. Stella VJ, Rao VM, Zannou EA, Zia V. 1999. Mechanisms of drug release from cyclodextrin complexes. Adv Drug Deliv Rev 36:3-16.
3. Charman SA, Perry CS, Chiu FCK, McIntosh KA, Prankerd RJ, Charman WN. 2006. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci 95:256-267.
4. Perry CS, Charman SA, Prankerd RJ, Chiu FCK, Scanlon MJ, Chalmers D, Charman WN. 2006. The binding interaction of synthetic ozonide antimalarials with natural and modified β-cyclodextrins. J Pharm Sci 95:146-158.
5. Yalkowsky SH, He Y. 2003. Handbook of aqueous solubility data. Boca Raton FL: CRC Press LLC. xii.
6. Luxnat M, Galla HJ. 1986. Partition of chlorpromazine into lipid bilayer membranes: The effect of membrane structure and composition. Biochim Biophys Acta 856:274-282. (Pubitemid 16067480)
7. Atherton AD, Barry BW. 1985. Micellar properties of phenothiazine drugs: A laser light scattering study. J Colloid Interface Sci 106:479-489.
8. Cheng SW, Shanker R, Lindenbaum S. 1990. Thermodynamics and mathematical modeling of the partitioning of chlorpromazine between n-octanol and aqueous buffer. Pharm Res 7:856-862. (Pubitemid 20332539)
9. Wajnberg E, Tabak M, Nussenzveig PA, Lopes CMB, Louro SRW. 1988. pH-dependent phase transition of chlorpromazine micellar solutions in the physiological range. Biochim Biophys Acta 944:185-190.
10. Saito YD, Tehrani S, Okamoto MM, Chang HH, Dea P. 2000. Calorimetry studies of chlorpromazine hydrochloride in solution. Langmuir 16:6391-6395.
11. Funasaki N, Hada S, Paiement J. 1991. Chromatographic study on the self-association of chlorpromazine hydrochloride in sodium chloride solution. J Phys Chem 95:4131-4135.
12. Attwood D, Fletcher P, Boitard E, Dubès JP, Tachoire H. 1990. A calorimetric study on the self-association of an amphiphilic phenothiazine drug in aqueous electrolyte solutions. J Phys Chem 94:6034-6041.
13. Attwood D, Florence AT. 1983. Surfactant systems: Their chemistry, pharmacy, and biology, edition. London: Chapman and Hall. p 794.
14. Stella VJ, He Q. 2008. Cyclodextrins. Toxicol Pathol 36:30-42.
15. Akhigbe RE, Azeez MO, Ige SF, Oyeyipo IP, Ajao FO, Soladoye AO. 2008. Hemorheological effects of long-term administration of combined oral contraceptive in rats. Int J Pharmacol 4:403-406.
16. Miller PL, Meyer TW. 1988. Plasma protein concentration and colloid osmotic pressure in nephrotic rats. Kidney Int 34:220-223.
17. Sato S, Koshiro A. 1995. Protein binding of chlorpromazine in vivo and in vitro: Effect of chlorpromazine metabolite on chlorpromazine protein binding in rat. Biol Pharm Bull 18:586-592.
18. Brewster ME, Anderson WR, Meinsma D, Moreno D, Webb AI, Pablo L, Estes KS, Derendorf H, Bodor N, Sawchuk R, Cheung B, Pop E. 1997. Intravenous and oral pharmacokinetic evaluation of a 2-hydroxypropyl-β-cyclodextrin-based formulation of carbamazepine in the dog: Comparison with commercially available tablets and suspensions. J Pharm Sci 86:335-339. (Pubitemid 27113768)
19. Dietzel K, Estes KS, Brewster ME, Bodor NS, Derendorf H. 1990. The use of 2-hydroxypropyl-[beta]-cyclodextrin as a vehicle for intravenous administration of dexamethasone in dogs. Int J Pharm 59:225-230.
20. Okimoto K, Ohike A, Ibuki R, Aoki O, Ohnishi N, Irie T, Uekama K, Rajewski RA, Stella VJ. 1999. Design and evaluation of an osmotic pump tablet (OPT) for chlorpromazine using (SBE)7m-beta-CD. Pharm Res 16:549-554.