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Volumn 4, Issue 2, 2010, Pages 122-131

Recent patents on immunoregulatory DNA vaccines for autoimmune diseases and allograft rejection

Author keywords

Autoimmune disease; Clinical trial; CpG dinucleotide; DNA vaccine; Immune tolerance; Inflammation; Molecular adjuvant; Organ transplantation; Rodent model system

Indexed keywords

AUTOANTIGEN; CYCLOPHOSPHAMIDE; DNA VACCINE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUTAMATE DECARBOXYLASE; GROWTH FACTOR; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 65; INSULIN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN; MYELIN; MYELIN ASSOCIATED GLYCOPROTEIN; PLASMID DNA; PREPROINSULIN; PREPROINSULIN 1; PREPROINSULIN 2; PROTEIN BAX; RAPAMYCIN; UNCLASSIFIED DRUG;

EID: 78649638994     PISSN: 18722156     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221510793205700     Document Type: Article
Times cited : (2)

References (50)
  • 1
    • 70249092211 scopus 로고    scopus 로고
    • DNA vaccines for autoimmune diseases
    • Garren H. DNA vaccines for autoimmune diseases. Expert Rev Vaccines 2009; 8: 1195-203.
    • (2009) Expert Rev Vaccines , vol.8 , pp. 1195-1203
    • Garren, H.1
  • 2
    • 0034123851 scopus 로고    scopus 로고
    • Dendritic cells at a DNA vaccination site express the encoded influenza nucleoprotein and prime MHC class I-restricted cytolytic lymphocytes upon adoptive transfer
    • Bot A, Stan AC, Inaba K, Steinman R, Bona C. Dendritic cells at a DNA vaccination site express the encoded influenza nucleoprotein and prime MHC class I-restricted cytolytic lymphocytes upon adoptive transfer. Int Immunol 2000; 12: 825-32.
    • (2000) Int Immunol , vol.12 , pp. 825-832
    • Bot, A.1    Stan, A.C.2    Inaba, K.3    Steinman, R.4    Bona, C.5
  • 3
    • 0032711215 scopus 로고    scopus 로고
    • In vivo priming by DNA injection occurs predominantly by antigen transfer
    • Corr M, von Damm A, Lee DJ, Tighe H. In vivo priming by DNA injection occurs predominantly by antigen transfer. J Immunol 1999; 163: 4721-7.
    • (1999) J Immunol , vol.163 , pp. 4721-4727
    • Corr, M.1    von Damm, A.2    Lee, D.J.3    Tighe, H.4
  • 4
    • 0032737033 scopus 로고    scopus 로고
    • Altering the cellular location of an antigen expressed by a DNA-based vaccine modulates the immune response
    • Lewis PJ, van Drunen lvdH, Babiuk LA. Altering the cellular location of an antigen expressed by a DNA-based vaccine modulates the immune response. J Virol 1999; 73: 10214-23.
    • (1999) J Virol , vol.73 , pp. 10214-23
    • Lewis, P.J.1    van Drunen, H.2    Babiuk, L.A.3
  • 5
    • 1842584372 scopus 로고    scopus 로고
    • Co-delivery of proapoptotic BAX with a DNA vaccine recruits dendritic cells and promotes efficacy of autoimmune diabetes prevention in mice
    • Li AF, Hough J, Henderson D, Escher A. Co-delivery of proapoptotic BAX with a DNA vaccine recruits dendritic cells and promotes efficacy of autoimmune diabetes prevention in mice. Vaccine 2004; 22: 1751-63.
    • (2004) Vaccine , vol.22 , pp. 1751-1763
    • Li, A.F.1    Hough, J.2    Henderson, D.3    Escher, A.4
  • 7
    • 77952117132 scopus 로고    scopus 로고
    • DNA vaccines for transplantation
    • Li AF, Escher A. DNA vaccines for transplantation. Expert Opin Biol Ther 2010; 10: 903-15.
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 903-915
    • Li, A.F.1    Escher, A.2
  • 8
    • 3843119002 scopus 로고    scopus 로고
    • Induction of protective therapy for autoimmune diseases by targeted DNA vaccines encoding pro-inflammatory cytokines and chemokines
    • Karin N. Induction of protective therapy for autoimmune diseases by targeted DNA vaccines encoding pro-inflammatory cytokines and chemokines. Curr Opin Mol Ther 2004; 6: 27-33.
    • (2004) Curr Opin Mol Ther , vol.6 , pp. 27-33
    • Karin, N.1
  • 9
    • 0029796099 scopus 로고    scopus 로고
    • Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity
    • Waisman A, Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg JR, Brocke S, et al. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat Med 1996; 2: 899-905.
    • (1996) Nat Med , vol.2 , pp. 899-905
    • Waisman, A.1    Ruiz, P.J.2    Hirschberg, D.L.3    Gelman, A.4    Oksenberg, J.R.5    Brocke, S.6
  • 10
    • 0034985055 scopus 로고    scopus 로고
    • Induction of a type 1 regulatory CD4 T cell response following V beta 8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis
    • Kumar V, Maglione J, Thatte J, Pederson B, Sercarz E, Ward ES. Induction of a type 1 regulatory CD4 T cell response following V beta 8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis. Int Immunol 2001; 13: 835-41.
    • (2001) Int Immunol , vol.13 , pp. 835-841
    • Kumar, V.1    Maglione, J.2    Thatte, J.3    Pederson, B.4    Sercarz, E.5    Ward, E.S.6
  • 11
    • 36048930464 scopus 로고    scopus 로고
    • Cells of the synovium in rheumatoid arthritis. B cells
    • Mauri C, Ehrenstein MR. Cells of the synovium in rheumatoid arthritis. B cells. Arthritis Res Ther 2007; 9: 205.
    • (2007) Arthritis Res Ther , vol.9 , pp. 205
    • Mauri, C.1    Ehrenstein, M.R.2
  • 15
    • 0035573750 scopus 로고    scopus 로고
    • Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice
    • Filippova M, Liu J, Escher A. Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice. DNA Cell Biol 2001; 3: 175-81.
    • (2001) DNA Cell Biol , vol.3 , pp. 175-181
    • Filippova, M.1    Liu, J.2    Escher, A.3
  • 17
    • 33750833099 scopus 로고    scopus 로고
    • Cyclophosphamideinduced type-1 diabetes in the NOD mouse is associated with a reduction of CD4+CD25+Foxp3+ regulatory T cells
    • Brode S, Raine T, Zaccone P, Cooke A. Cyclophosphamideinduced type-1 diabetes in the NOD mouse is associated with a reduction of CD4+CD25+Foxp3+ regulatory T cells. J Immunol. 2006; 177: 6603-12.
    • (2006) J Immunol , vol.177 , pp. 6603-6612
    • Brode, S.1    Raine, T.2    Zaccone, P.3    Cooke, A.4
  • 18
    • 0035253510 scopus 로고    scopus 로고
    • Antigen- specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination
    • Tisch R, Wang B, Weaver DJ, Liu B, Bui T, Arthos J, et al. Antigen- specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination. J Immunol 2001; 166: 2122-32.
    • (2001) J Immunol , vol.166 , pp. 2122-2132
    • Tisch, R.1    Wang, B.2    Weaver, D.J.3    Liu, B.4    Bui, T.5    Arthos, J.6
  • 19
    • 12444315123 scopus 로고    scopus 로고
    • Regulatory cytokine production stimulated by DNA vaccination against an altered form of glutamic acid decarboxylase 65 in nonobese diabetic mice
    • Glinka Y, De Pooter R, Croze F, Prud'homme GJ. Regulatory cytokine production stimulated by DNA vaccination against an altered form of glutamic acid decarboxylase 65 in nonobese diabetic mice. J Mol Med 2003; 81: 175-84.
    • (2003) J Mol Med , vol.81 , pp. 175-184
    • Glinka, Y.1    de Pooter, R.2    Croze, F.3    Prud'homme, G.J.4
  • 21
    • 33646863868 scopus 로고    scopus 로고
    • Proapoptotic DNA vaccination ameliorates new onset of autoimmune diabetes in NOD mice and induces foxp3+ regulatory T cells in vitro
    • Li A, Ojogho O, Franco E, Baron P, Iwaki Y, Escher A. Proapoptotic DNA vaccination ameliorates new onset of autoimmune diabetes in NOD mice and induces foxp3+ regulatory T cells in vitro. Vaccine 2006; 24: 5036-46.
    • (2006) Vaccine , vol.24 , pp. 5036-5046
    • Li, A.1    Ojogho, O.2    Franco, E.3    Baron, P.4    Iwaki, Y.5    Escher, A.6
  • 22
    • 45449103457 scopus 로고    scopus 로고
    • Innate apoptotic immunity: The calming touch of death
    • Birge RB, Ucker DS. Innate apoptotic immunity: the calming touch of death. Cell Death Differ 2008; 15: 1096-102.
    • (2008) Cell Death Differ , vol.15 , pp. 1096-1102
    • Birge, R.B.1    Ucker, D.S.2
  • 26
    • 0142210343 scopus 로고    scopus 로고
    • An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems
    • Ho PP, Fontoura P, Ruiz PJ, Steinman L, Garren H. An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems. J Immunol 2003; 171: 4920-6.
    • (2003) J Immunol , vol.171 , pp. 4920-4926
    • Ho, P.P.1    Fontoura, P.2    Ruiz, P.J.3    Steinman, L.4    Garren, H.5
  • 28
    • 2142707263 scopus 로고    scopus 로고
    • DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response
    • Mimran A, Mor F, Carmi P, Quintana FJ, Rotter V, Cohen IR. DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response. J Clin Invest 2004; 113: 924-32.
    • (2004) J Clin Invest , vol.113 , pp. 924-932
    • Mimran, A.1    Mor, F.2    Carmi, P.3    Quintana, F.J.4    Rotter, V.5    Cohen, I.R.6
  • 29
    • 56149086005 scopus 로고    scopus 로고
    • Spotlight on anti-CD25: Daclizumab in MS
    • Schippling DS, Martin R. Spotlight on anti-CD25: daclizumab in MS. Int MS J 2008; 15: 94-8.
    • (2008) Int MS J , vol.15 , pp. 94-98
    • Schippling, D.S.1    Martin, R.2
  • 32
    • 77149175945 scopus 로고    scopus 로고
    • Autoimmune diseases: MIF as a therapeutic target
    • Greven D, Leng L, Bucala R. Autoimmune diseases: MIF as a therapeutic target. Expert Opin Ther Targets 2010; 14: 253-64.
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 253-264
    • Greven, D.1    Leng, L.2    Bucala, R.3
  • 34
    • 33748168720 scopus 로고    scopus 로고
    • Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand
    • Glinka Y, Chang Y, Prud'homme GJ. Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand. Mol Ther 2006; 14: 578-87.
    • (2006) Mol Ther , vol.14 , pp. 578-587
    • Glinka, Y.1    Chang, Y.2    Prud'homme, G.J.3
  • 38
    • 34848865834 scopus 로고    scopus 로고
    • Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial
    • Bar-Or A, Vollmer T, Antel J, Arnold DL, Bodner CA, Campagnolo D, et al. Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial. Arch Neurol 2007; 64: 1407-15.
    • (2007) Arch Neurol , vol.64 , pp. 1407-1415
    • Bar-Or, A.1    Vollmer, T.2    Antel, J.3    Arnold, D.L.4    Bodner, C.A.5    Campagnolo, D.6
  • 39
    • 78651236176 scopus 로고    scopus 로고
    • Transplants in the U.S. by State. Available at, (Accessed on: April 19, 2010)
    • Organ Procurement and Transplantation Network. Transplants in the U.S. by State. Available at: http://optn.transplant.hrsa.gov/latestData/rptData.asp. (Accessed on: April 19, 2010).
    • Organ Procurement and Transplantation Network
  • 40
    • 33749428991 scopus 로고    scopus 로고
    • Composite tissue allotransplantation of the hand and face: A new frontier in transplant and reconstructive surgery
    • Gander B, Brown CS, Vasilic D, Furr A, Banis JC Jr, Cunningham M, et al. Composite tissue allotransplantation of the hand and face: a new frontier in transplant and reconstructive surgery. Transpl Int 2006; 19: 868-80.
    • (2006) Transpl Int , vol.19 , pp. 868-880
    • Gander, B.1    Brown, C.S.2    Vasilic, D.3    Furr, A.4    Banis Jr., J.C.5    Cunningham, M.6
  • 41
    • 76949097361 scopus 로고    scopus 로고
    • A therapeutic DNA vaccination strategy for autoimmunity and transplantation
    • Li A, Chen J, Hattori M, Franco E, Zuppan C, Ojogho O, et al. A therapeutic DNA vaccination strategy for autoimmunity and transplantation. Vaccine 2010; 28: 1897-904.
    • (2010) Vaccine , vol.28 , pp. 1897-1904
    • Li, A.1    Chen, J.2    Hattori, M.3    Franco, E.4    Zuppan, C.5    Ojogho, O.6
  • 43
    • 0036681969 scopus 로고    scopus 로고
    • Modulation of tissue-specific immune response to cardiac myosin can prolong survival of allogeneic heart transplants
    • Fedoseyeva EV, Kishimoto K, Rolls HK, Illigens BM, Dong VM, Valujskikh A, et al. Modulation of tissue-specific immune response to cardiac myosin can prolong survival of allogeneic heart transplants. J Immunol 2002; 169: 1168-74.
    • (2002) J Immunol , vol.169 , pp. 1168-1174
    • Fedoseyeva, E.V.1    Kishimoto, K.2    Rolls, H.K.3    Illigens, B.M.4    Dong, V.M.5    Valujskikh, A.6
  • 44
    • 68949116246 scopus 로고    scopus 로고
    • Type V collagen-induced oral tolerance plus low-dose cyclosporine prevents rejection of MHC class I and II incompatible lung allografts
    • Yamada Y, Sekine Y, Yoshida S, Yasufuku K, Petrache I, Benson HL, et al. Type V collagen-induced oral tolerance plus low-dose cyclosporine prevents rejection of MHC class I and II incompatible lung allografts. J Immunol 2009; 183: 237-45.
    • (2009) J Immunol , vol.183 , pp. 237-245
    • Yamada, Y.1    Sekine, Y.2    Yoshida, S.3    Yasufuku, K.4    Petrache, I.5    Benson, H.L.6
  • 47
    • 33845703838 scopus 로고    scopus 로고
    • GABAsynthesizing enzyme, GAD67, from dermal fibroblasts: Evidence for a new skin function
    • Ito K, Tanaka K, Nishibe Y, Hasegawa J, Ueno H. GABAsynthesizing enzyme, GAD67, from dermal fibroblasts: evidence for a new skin function. Biochim Biophys Acta 2007; 1770: 291-6.
    • (2007) Biochim Biophys Acta , vol.1770 , pp. 291-296
    • Ito, K.1    Tanaka, K.2    Nishibe, Y.3    Hasegawa, J.4    Ueno, H.5
  • 48
    • 0037091044 scopus 로고    scopus 로고
    • Development of autoimmunity after skin graft rejection via an indirect alloresponse
    • Valujskikh A, Fedoseyeva E, Benichou G, Heeger PS. Development of autoimmunity after skin graft rejection via an indirect alloresponse. Transplantation 2002; 73: 1130-7.
    • (2002) Transplantation , vol.73 , pp. 1130-1137
    • Valujskikh, A.1    Fedoseyeva, E.2    Benichou, G.3    Heeger, P.S.4
  • 49
    • 0141514404 scopus 로고    scopus 로고
    • Immunization with DNA through the skin
    • Peachman KK, Rao M, Alving CR. Immunization with DNA through the skin. Methods 2003; 31: 232-42.
    • (2003) Methods , vol.31 , pp. 232-242
    • Peachman, K.K.1    Rao, M.2    Alving, C.R.3
  • 50
    • 58849117178 scopus 로고    scopus 로고
    • Improved efficacy of a tolerizing DNA vaccine for reversal of hyperglycemia through enhancement of gene expression and localization to intracellular sites
    • Solvason N, Lou YP, Peters W, Evans E, Martinez J, Ramirez U, et al. Improved efficacy of a tolerizing DNA vaccine for reversal of hyperglycemia through enhancement of gene expression and localization to intracellular sites. J Immunol 2008; 181: 8298-307.
    • (2008) J Immunol , vol.181 , pp. 8298-8307
    • Solvason, N.1    Lou, Y.P.2    Peters, W.3    Evans, E.4    Martinez, J.5    Ramirez, U.6


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