Hypercapnic acidosis preserves gastric mucosal microvascular oxygen saturation in a canine model of hemorrhage

Shock

Volumn 34, Issue 6, 2010, Pages 636-642

  Schwartges, Ingo ^a   Picker, Olaf ^a   Beck, Christopher ^a   Scheeren, Thomas W L ^a,b   Schwarte, Lothar A ^a,c  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

gastrointestinal microcirculation; hemorrhagic shock; Respiratory acidosis; splanchnic mucosa; tissue oxygenation

Indexed keywords

SEVOFLURANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; ATTENUATION; BLEEDING; DOG; EXPERIMENTAL MODEL; FEMALE; HEART OUTPUT; HYPERCAPNIA; HYPERCAPNIC ACIDOSIS; HYPOVOLEMIA; LUNG VENTILATION; MALE; NONHUMAN; OXYGEN SATURATION; PROSPECTIVE STUDY; STOMACH MUCOSA;

ACIDOSIS, RESPIRATORY; ANIMALS; DOGS; FEMALE; GASTRIC MUCOSA; HYPERCAPNIA; MALE; MICROCIRCULATION; OXYGEN; RANDOM ALLOCATION; SHOCK, HEMORRHAGIC;

EID: 78649633354     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181e68422     Document Type: Article

References (42)

1. Heckbert SR, Vedder NB, Hoffman W, Winn RK, Hudson LD, Jurkovich GJ, Copass MK, Harlan JM, Rice CL, Maier RV: Outcome after hemorrhagic shock in trauma patients. J Trauma 45:545-549, 1998.
2. Faist E, Baue AE, Dittmer H, Heberer G: Multiple organ failure in polytrauma patients. J Trauma 23:775-787, 1983. (Pubitemid 13008526)
3. Rush BF Jr, Sori AJ, Murphy TF, Smith S, Flanagan JJ Jr, Machiedo GW: Endotoxemia and bacteremia during hemorrhagic shock. The link between trauma and sepsis? Ann Surg 207:549-554, 1988.
4. Yao YM, Sheng ZY, Tian HM, Wang YP, Yu Y, Fu XB, Lu LR, Wang DW, Ma YY: Gut-derived endotoxemia and multiple system organ failure following gunshot wounds combined with hemorrhagic shock: an experimental study in the dog. J Trauma 38:742-746, 1995.
5. Doglio GR, Pusajo JF, Egurrola MA, Bonfigli GC, Parra C, Vetere L, Hernandez MS, Fernandez S, Palizas F, Gutierrez G: Gastric mucosal pH as a prognostic index of mortality in critically ill patients. Crit Care Med 19:1037-1040, 1991.
6. Shi AG, Ahmad S, Kwan CY, Daniel EE: Alpha-adrenoceptors in dog mes-enteric vesselsVsubcellular distribution and number of [3H]prazosin and [3H]rauwolscine binding sites. J Cardiovasc Pharmacol 15:515-526, 1990.
7. Wall P, Buising C, Henderson L, Rickers T, Cardenas A, Owens L, Timberlake G, Paradise N: Enalaprilat improves systemic cardiovascular parameters and mesenteric blood flow during hypotensive resuscitation from hemorrhagic shock in dogs. Shock 17:228-233, 2002.
8. Liard JF, Deriaz O, Schelling P, Thibonnier M: Cardiac output distribution during vasopressin infusion or dehydration in conscious dogs. Am J Physiol 243:H663-H669, 1982.
9. Dalton JM, Gore DC, Makhoul RG, Fisher MR, DeMaria EJ: Decreased splanchnic perfusion measured by duplex ultrasound in humans undergoing small volume hemorrhage. Crit Care Med 23:491-497, 1995.
10. Vatner SF: Effects of hemorrhage on regional blood flow distribution in dogs and primates. J Clin Invest 54:225-235, 1974.
11. Holland J, Carey M, Hughes N, Sweeney K, Byrne PJ, Healy M, Ravi N, Reynolds JV: Intraoperative splanchnic hypoperfusion, increased intestinal permeability, down-regulation of monocyte class II major histocompatibility complex expression, exaggerated acute phase response, and sepsis. Am J Surg 190:393-400, 2005.
12. Dubin A, Pozo MO, Ferrara G, Murias G, Martins E, Canullan C, Canales HS, Kanoore Edul VS, Estenssoro E, Ince C: Systemic and microcirculatory responses to progressive hemorrhage. Intensive Care Med 35:556-564, 2009.
13. Edouard AR, Degremont AC, Duranteau J, Pussard E, Berdeaux A, Samii K: Heterogeneous regional vascular responses to simulated transient hypovolemia in man. Intensive Care Med 20:414-420, 1994.
14. Cohn SM, Nathens AB, Moore FA, Rhee P, Puyana JC, Moore EE, Beilman GJ: Tissue oxygen saturation predicts the development of organ dysfunction during traumatic shock resuscitation. J Trauma 62:44-54, 2007 [discussion 54-55].
15. Schwartges I, Schwarte LA, Fournell A, Scheeren TW, Picker O: Hypercapnia induces a concentration-dependent increase in gastric mucosal oxygenation in dogs. Intensive Care Med 34:1898-1906, 2008.
16. Picker O, Schindler A, Scheeren TW: Accuracy and reproducibility of long-term implanted transit-time ultrasound flow probes in dogs. Intensive Care Med 26:601-607, 2000.
17. Greene SA, Benson GJ, Tranquilli WJ, Grimm KA: Relationship of canine bispectral index to multiples of sevoflurane minimal alveolar concentration, using patch or subdermal electrodes. Comp Med 52:424-428, 2002.
18. Scheeren TW, Schwarte LA, Loer SA, Picker O, Fournell A: Dopexamine but not dopamine increases gastric mucosal oxygenation during mechanical ventilation in dogs. Crit Care Med 30:881-887, 2002.
19. Frank KH, Kessler M, Appelbaum K, Dummler W: The Erlangen micro-lightguide spectrophotometer EMPHO I. Phys Med Biol 34:1883-1900, 1989.
20. Scheeren TWL, Krossa M, Merilainen P, Arndt JO: Error in measurement of oxygen and carbon dioxide concentrations by the DeltaTracII metabolic monitor in the presence of desflurane. Br J Anaesth 80:521-524, 1998.
21. Picker O, Wietasch G, Scheeren TW, Arndt JO: Determination of total blood volume by indicator dilution: a comparison of mean transit time and mass conservation principle. Intensive Care Med 27:767-774, 2001.
22. 2. Chest 130:85-92, 2006.
23. Kuchenreuther S, Adler J, Schutz W, Eichelbronner O, Georgieff M: The Erlanger Microlightguide Photometer: a new concept for monitoring intra-capillary oxygen supply of tissueVfirst results and a review of the physiological basis. J Clin Monit 12:211-224, 1996.
24. Adolphs J, Schmidt DK, Mousa SA, Kamin B, Korsukewitz I, Habazettl H, Schafer M, Welte M: Thoracic epidural anesthesia attenuates hemorrhage-induced impairment of intestinal perfusion in rats. Anesthesiology 99:685-692, 2003.
25. Leung FW, Morishita T, Livingston EH, Reedy T, Guth PH: Reflectance spectrophotometry for the assessment of gastroduodenal mucosal perfusion. Am J Physiol 252:G797-G804, 1987.
26. Picker O, Schwarte LA, Roth HJ, Greve J, Scheeren TW: Comparison of the role of endothelin, vasopressin and angiotensin in arterial pressure regulation during sevoflurane anaesthesia in dogs. Br J Anaesth 92:102-108, 2004.
27. Victorino GP, Battistella FD, Wisner DH: Does tachycardia correlate with hypotension after trauma? J Am Coll Surg 196:679-684, 2003.
28. Ramirez J, Totapally BR, Hon E, Torbati D, Mangino MJ, Hultquist KA, Wolfsdorf J: Oxygen-carrying capacity during 10 hours of hypercapnia in ventilated dogs. Crit Care Med 28:1918-1923, 2000.
29. Torbati D, Mangino MJ, Garcia E, Estrada M, Totapally BR, Wolfsdorf J: Acute hypercapnia increases the oxygen-carrying capacity of the blood in ventilated dogs. Crit Care Med 26:1863-1867, 1998.
30. Costello J, Higgins B, Contreras M, Chonghaile MN, Hassett P, O'Toole D, Laffey JG: Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis. Crit Care Med 37:2412-2420, 2009.
31. Wang Z, Su F, Bruhn A, Yang X, Vincent JL: Acute hypercapnia improves indices of tissue oxygenation more than dobutamine in septic shock. Am J Respir Crit Care Med 177:178-183, 2008.
32. Higgins BD, Costello J, Contreras M, Hassett P, O'Toole D, Laffey JG: Differential effects of buffered hypercapnia versus hypercapnic acidosis on shock and lung injury induced by systemic sepsis. Anesthesiology 111: 1317-1326, 2009.
33. Hood VL, Tannen RL: Protection of acid-base balance by pH regulation of acid production. N Engl J Med 339:819-826, 1998.
34. Swenson ER, Robertson HT, Hlastala MP: Effects of inspired carbon dioxide on ventilation-perfusion matching in normoxia, hypoxia, and hyperoxia. Am J Respir Crit Care Med 149:1563-1569, 1994.
35. Agostoni A, Stabilini R, Bernasconi C, Gerli GC: The oxyhemoglobin dissociation curve in hypercapnic patients. Am Heart J 87:670-672, 1974.
36. Fournell A, Scheeren TW, Schwarte LA: Oxygenation of the intestinal mucosa in anaesthetized dogs is attenuated by intermittent positive pressure ventilation (IPPV) with positive end-expiratory pressure (PEEP). Adv Exp Med Biol 428: 385-389, 1997.
37. Jacobson ED: Physiology of the mesenteric circulation. Physiologist 25:439-443, 1982.
38. Brofman JD, Leff AR, Munoz NM, Kirchhoff C, White SR: Sympathetic secretory response to hypercapnic acidosis in swine. J Appl Physiol 69:710-717, 1990.
39. Mizukoshi Y, Shibata K, Yoshida M: Left ventricular contractility is reduced by hypercapnic acidosis and thoracolumbar epidural anesthesia in rabbits. Can J Anaesth 48:557-562, 2001.
40. Komori M, Takada K, Tomizawa Y, Nishiyama K, Kawamata M, Ozaki M: Permissive range of hypercapnia for improved peripheral microcirculation and cardiac output in rabbits. Crit Care Med 35:2171-2175, 2007.
41. Nakahata K, Kinoshita H, Hirano Y, Kimoto Y, Iranami H, Hatano Y: Mild 'hypercapnia induces vasodilation via adenosine triphosphate-sensitive K+ channels in parenchymal microvessels of the rat cerebral cortex. Anesthesiology 99:1333-1339, 2003.
42. Cardenas VJ Jr, Zwischenberger JB, Tao W, Nguyen PD, Schroeder T, Traber LD, Traber DL, Bidani A: Correction of blood pH attenuates changes in hemodynamics and organ blood flow during permissive hypercapnia. Crit Care Med 24:827-834, 1996.